1. < Prostate Cancer
Profile picture for Jeff Marchi

Prostox - learn about whether radiation will cause problems

Posted by Jeff Marchi @jeffmarc, Apr 12 8:59pm

The Prostox test evaluates whether or not you will have side effects from having different types of radiation.

PROSTOX works not just for first time radiation but for recurrence and maybe even radioligand therapy like Pluvicto. By analyzing your unique genetics, you can make smarter, more informed decisions to avoid side effects and safeguard your quality of life for years to come.
PROSTOX Standard (previously PROSTOX CFRT+) predicts late grade ≥2 toxicity from conventionally fractionated (CFRT) or moderately hypofractionated (MHFRT) radiation therapy for patients with localized prostate cancer.
Together with PROSTOX Ultra, which is already available for patients considering stereotactic body radiation therapy (SBRT), the PROSTOX portfolio now provides risk assessment across a broader range of external beam radiation therapy (EBRT) types.
We'll discuss the updates and other patient concerns such as insurance coverage and questions to bring to your doctors.
Join us April 27th, 2026 for a special presentation by test developer, Dr. Joanne Weidhaas, 7:00 - 7:55 pm Eastern - Dr. Weidhaas Presentation in the AnCan Barniskis Room

You do need to Goto meeting installed in order to attend this event

Just put Barniskis for the session to join

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for charlesprestridge
charlesprestridge | @charlesprestridge | Apr 15 9:03am
In reply to @climateguy "@charlesprestridge The associated website, MiraKind, has a FAQ that among other things says Prostox has not..." + (show)
Profile picture for climateguy @climateguy

@charlesprestridge The associated website, MiraKind, has a FAQ that among other things says Prostox has not been validated for brachytherapy. https://mirakind.org/prostox-testing/

They are investigating. I called them asking if I got the test and then had 20 sessions of external beam plus a brachytherapy boost, would they be able to use the data for a future validation. They said no. They have a selected group of patients for validation.

The Dr. Joanne Weidhaas who will be presenting at the upcoming AnCan GoTo meeting, was interviewed by P.C.R.I. about 8 months ago.

Jump to this post

@climateguy

Thank you very much.

REPLY
Profile picture for Jeff Marchi
Jeff Marchi | @jeffmarc | Apr 15 10:35am

Here is a link to the first Prostox Presentation at Ancan.Org done by The developer of the test.
https://ancan.org/

REPLY
Profile picture for K. J. HOLZ
K. J. HOLZ | @kjholz | Apr 15 12:00pm
In reply to @quaddick "Prostox was the pivotal test in my choice of RP. I was leaning towards SBRT, but..." + (show)
Profile picture for quaddick @quaddick

Prostox was the pivotal test in my choice of RP. I was leaning towards SBRT, but the Prostox results put me at high risk for both SBRT and IMRT. I'm almost 3 months post RARP and my continence is almost fully recovered. For me, RALP was the best choice.
BTW, the test cost me nothing due to my zip code. Check with the Prostox company and there's a very good chance that you can get the test free or at a discount.

Jump to this post

@quaddick Hi Quaddick! Like you, my husband is one of the "rare" 1-2% who Prostox scored "High Risk" for both SBRT and CFRT/IMRT.

Last week he successfully underwent TULSA-Pro. Six days later he got his catheter out! ....Thank you Prostox.

REPLY
Profile picture for charlesprestridge
charlesprestridge | @charlesprestridge | Apr 27 6:52pm

@jeffmarc

Thank you for letting me know about this webinar. Very good meeting.

I am grateful for all of your help and answers.

Presentation and questions very helpful.

REPLY
1 reply
Profile picture for Jeff Marchi
Jeff Marchi | @jeffmarc | Apr 27 7:40pm
In reply to @charlesprestridge "@jeffmarc Thank you for letting me know about this webinar. Very good meeting. I am grateful..." + (show)
Profile picture for charlesprestridge @charlesprestridge

@jeffmarc

Thank you for letting me know about this webinar. Very good meeting.

I am grateful for all of your help and answers.

Presentation and questions very helpful.

Jump to this post

@charlesprestridge
I attended it too, as you may have noticed. It was definitely very informative. They recorded it so other people should be able to watch it if they missed it.

REPLY
1 reply
Profile picture for Jeff Marchi
Jeff Marchi | @jeffmarc | Apr 28 11:51am
In reply to @jeffmarc "@charlesprestridge I attended it too, as you may have noticed. It was definitely very informative. They..." + (show)
Profile picture for Jeff Marchi @jeffmarc

@charlesprestridge
I attended it too, as you may have noticed. It was definitely very informative. They recorded it so other people should be able to watch it if they missed it.

Jump to this post

@jeffmarc
I realized that I had not mentioned there was a Prostox Presentation yesterday 4-26-26 with the same radiation oncologist that did it last time.

A lot of talk about the SBRT test as well as the one for EBRT. The only one they don’t have a test for is low-dose brachytherapy Because that is one they don’t think there is an issue with. They mentioned that the SBRT test is also applicable to High dose brachytherapy.

Yesterday‘s meeting should be available to watch in the next few days at ancan.org, just search for Prostox.

I included one slide from the presentation, Who discusses what percent of people do have a problem with each of the tests. They did find that between 1% and 2% of the population have problems with both types of radiation.
REPLY
2 replies
Profile picture for K. J. HOLZ
K. J. HOLZ | @kjholz | Apr 29 7:25am
In reply to @jeffmarc "@jeffmarc I realized that I had not mentioned there was a Prostox Presentation yesterday 4-26-26 with..." + (show)
Profile picture for Jeff Marchi @jeffmarc

@jeffmarc
I realized that I had not mentioned there was a Prostox Presentation yesterday 4-26-26 with the same radiation oncologist that did it last time.

A lot of talk about the SBRT test as well as the one for EBRT. The only one they don’t have a test for is low-dose brachytherapy Because that is one they don’t think there is an issue with. They mentioned that the SBRT test is also applicable to High dose brachytherapy.

Yesterday‘s meeting should be available to watch in the next few days at ancan.org, just search for Prostox.

I included one slide from the presentation, Who discusses what percent of people do have a problem with each of the tests. They did find that between 1% and 2% of the population have problems with both types of radiation.

Jump to this post

@jeffmarc re [Prostox] did find that between 1% and 2% of the population have problems with both types of radiation."

Yep. We were deciding between SBRT and IMRT and we ordered both Prostox tests to help us decide.

And here's what a 1-2% Prostox "High Risk" for SBRT *and* IMRT looks like. 👇

REPLY
2 replies
Profile picture for K. J. HOLZ
K. J. HOLZ | @kjholz | Apr 29 8:18am
In reply to @kjholz "@jeffmarc re [Prostox] did find that between 1% and 2% of the population have problems with..." + (show)
Profile picture for K. J. HOLZ @kjholz

@jeffmarc re [Prostox] did find that between 1% and 2% of the population have problems with both types of radiation."

Yep. We were deciding between SBRT and IMRT and we ordered both Prostox tests to help us decide.

And here's what a 1-2% Prostox "High Risk" for SBRT *and* IMRT looks like. 👇

Jump to this post

deleted

REPLY
Profile picture for K. J. HOLZ
K. J. HOLZ | @kjholz | Apr 29 8:27am
In reply to @jeffmarc "@jeffmarc I realized that I had not mentioned there was a Prostox Presentation yesterday 4-26-26 with..." + (show)
Profile picture for Jeff Marchi @jeffmarc

@jeffmarc
I realized that I had not mentioned there was a Prostox Presentation yesterday 4-26-26 with the same radiation oncologist that did it last time.

A lot of talk about the SBRT test as well as the one for EBRT. The only one they don’t have a test for is low-dose brachytherapy Because that is one they don’t think there is an issue with. They mentioned that the SBRT test is also applicable to High dose brachytherapy.

Yesterday‘s meeting should be available to watch in the next few days at ancan.org, just search for Prostox.

I included one slide from the presentation, Who discusses what percent of people do have a problem with each of the tests. They did find that between 1% and 2% of the population have problems with both types of radiation.

Jump to this post

@jeffmarc Thank you for the link to ancan.org.

The video "Predicting Radiation Side Effects – PROSTOX Webinar with interesting updates! April 27th, 2026" is now up.

REPLY
Profile picture for K. J. HOLZ
K. J. HOLZ | @kjholz | Apr 29 9:31am
In reply to @kjholz "Just need to give people a heads-up. Because my husband has a weak stream and a..." + (show)
Profile picture for K. J. HOLZ @kjholz

Just need to give people a heads-up. Because my husband has a weak stream and a 3+4 tumour in the right medial apex, we were worried that radiation could convert his existing weak stream into no-stream-at-all.

So we ordered both Prostox Ultra (SBRT) and Prostox Standard (CFRT) tests. Only 1%–2% of patients are found to be high risk of toxicity from both SBRT and CFRT/MHFRT. He scored "HIGH RISK" on both! Radiation was out!

Pic 1 👇 shows what our January 15, 2026 Prostox report looked like. It had just two risk categories. Either "LOW RISK" or "HIGH RISK".

I checked today and UCLA/Prostox has now changed their "Interpreting PROSTOX Results" report page to "LOW-AVERAGE RISK" or "HIGH RISK"!
https://miradx.com/prostox/interpreting-results/
From "LOW RISK" Jan 2026 to "LOW-AVERAGE RISK" now...

I wonder if page 2 of their current results report still includes:

"Limitations: Results do not predict a patient’s likelihood of clinical response, short-term side effects, or non-urinary side effects from SBRT or CFRT. A low-risk result does not rule out any possibility that the patient will experience toxicity, and a high-risk result does not guarantee that the patient will develop toxicity. Results should only be used as part of the
consideration of treatment choice."

Jump to this post

@kjholz My Apr 13 1:07pm comment:

"I checked today and UCLA/Prostox has now changed their "Interpreting PROSTOX Results" report page to "LOW-AVERAGE RISK" or "HIGH RISK"!
https://miradx.com/prostox/interpreting-results/
From "LOW RISK" Jan 2026 to "LOW-AVERAGE RISK" now..."

IS WRONG! And I don't know how to delete it.

Only today (April 29th) did I realize that Prostox results were NOT changed from a gradation that included "AVERAGE" to the binary "High" vs "Low" risks.

I had not noticed the date being *2022* and not 2026. Anyway, I was careless and wrong!

REPLY
Please sign in or register to post a reply.