Connect
Prostox - learn about whether radiation will cause problems
The Prostox test evaluates whether or not you will have side effects from having different types of radiation.
PROSTOX works not just for first time radiation but for recurrence and maybe even radioligand therapy like Pluvicto. By analyzing your unique genetics, you can make smarter, more informed decisions to avoid side effects and safeguard your quality of life for years to come.
PROSTOX Standard (previously PROSTOX CFRT+) predicts late grade ≥2 toxicity from conventionally fractionated (CFRT) or moderately hypofractionated (MHFRT) radiation therapy for patients with localized prostate cancer.
Together with PROSTOX Ultra, which is already available for patients considering stereotactic body radiation therapy (SBRT), the PROSTOX portfolio now provides risk assessment across a broader range of external beam radiation therapy (EBRT) types.
We'll discuss the updates and other patient concerns such as insurance coverage and questions to bring to your doctors.
Join us April 27th, 2026 for a special presentation by test developer, Dr. Joanne Weidhaas, 7:00 - 7:55 pm Eastern - Dr. Weidhaas Presentation in the AnCan Barniskis Room
You do need to Goto meeting installed in order to attend this event
Just put Barniskis for the session to join
Like
Helpful
HugInterested in more discussions like this? Go to the Prostate Cancer Support Group.
Connect
Prostox was the pivotal test in my choice of RP. I was leaning towards SBRT, but the Prostox results put me at high risk for both SBRT and IMRT. I'm almost 3 months post RARP and my continence is almost fully recovered. For me, RALP was the best choice.
BTW, the test cost me nothing due to my zip code. Check with the Prostox company and there's a very good chance that you can get the test free or at a discount.
-
Like -
Helpful -
Hug
3 Reactions@surftohealth88 What am advocate you are for your husband. I am a retired lawyer and nurse and you leave in the dust. Kudos to you.
-
Like -
Helpful -
Hug
2 Reactions@surftohealth88
There are no privacy issues. You don’t have to put your name on the login and you don’t have to turn your camera on. All options before you join the event. You could even put a fake name in. There’s no way to track you.
-
Like -
Helpful -
Hug
2 ReactionsI had proton radiation 9 years ago after a prostecomy to insure all the cancer was removed. It wasn't. My PSA returned and in 6 months so I've had 3 more rounds of different treatments. Last week I was diagnosed with radiation cystitis. I bleed through the urinary system. The blood clots and causes ED visits to be catheriterized so I can urinate. To help heal the bladder, I'm being referred to 40 consecutive treatments in a hyperbaric oxygen chamber. Bleeding starts now with minimal exercise or even straining during a bowel movement. Right now my cancer is under control (as of today my psa is < 0,05). It's the side effects of the treatments that I'm fighting now. Living with this disease will be a challenge to the end.
-
Like -
Helpful -
Hug
3 Reactions@29modela
I know other people that have had to do the hyperbaric Oxygen chamber treatment. It does work for most people.
Great to hear your PSA is so low.
-
Like -
Helpful -
Hug
1 Reaction@dhasper
Aaaaw @dhasper , thanks so much for your kind words 💗😌.
Does the Prostox test have value for HDR brachytherapy as a monotherapy?
I do not see it listed on their website.
Thanks
@charlesprestridge
I have not heard of it being included.
You could ask at the meeting.
-
Like -
Helpful -
Hug
2 Reactions@surftohealth88 The problem you are running into is that the company that markets Prostox wants to get it accepted by insurance and ROs so they are limiting it to where it has decision value and where they have done trials. In an Ancan presentation a few months ago they said they had not done any trials for salvage radiation. Said almost all salvage radiation was IMRT so no decision point. In the release of the standard test in Feb. 2026 they mentioned it covers CFRT for 37-45 fractions and MHFRT for 20-28 fractions. I assume the fractions quoted correspond to trials they have participated in and why 29-36 are missing. Medicine is a business and not enough money in pursuing salvage radiation testing at this time.
With no germline DNA repair variants your husband is less likely to have a high Prostox. Since Prostox requires a confirmed prostate cancer diagnosis (higher % than population with these) that will reduce his probability of a high Prostox below the 11% that score high. Prostox looks at 32 factors covering SNPs involved in DNA damage repair. inflammation, and cell stress response. So more global than just DNA repair. Like all other genetic tests this is a black box. Only general information on factors included and none on weighting. Also 8% who score low on Prostox will develop grade 2+ toxicity.
A retrospective study (80K+) of late grade 2+ GU toxicity found 90%+ were obstruction/stricture of the urethra. Patients with previous issues/treatments such as Turp were 3x more likely to have late toxicity than without any issues. Radiation still raised probability for both groups. Other common GI toxicity was 5%+ cystitis, 2% incontinence. Prostox does not cover GI toxicity.
@charlesprestridge The associated website, MiraKind, has a FAQ that among other things says Prostox has not been validated for brachytherapy. https://mirakind.org/prostox-testing/
They are investigating. I called them asking if I got the test and then had 20 sessions of external beam plus a brachytherapy boost, would they be able to use the data for a future validation. They said no. They have a selected group of patients for validation.
The Dr. Joanne Weidhaas who will be presenting at the upcoming AnCan GoTo meeting, was interviewed by P.C.R.I. about 8 months ago.