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Has anyone else had antibiotic sensitivity?

Posted by notnancy88 @notnancy88, Apr 25 4:43pm

I have had it done twice since spring 2023. It is surprising that suddenly antibiotics that you were sensitive to before no longer have that same sensitivity. I’ve recently learned that AZRITHOMYCIN ( sp) and MOXIEFLOXICIN is useless when trying to treat something that I have been diagnosed with.

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fdixon63 | @fdixon63 | Apr 28 6:20pm
In reply to @rc4mc "I was on azythromycin, rifampin, and ethambutol, Mon-Wed-Fri for 2 weeks in September 2025 when my..." + (show)
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I was on azythromycin, rifampin, and ethambutol, Mon-Wed-Fri for 2 weeks in September 2025 when my cough completely went away. Mind you, I'd had this cough since ~2015 and it got much worse over the past 2 years. In December 2025, the doc stopped Ethambutol (didn't think it was worth the side effects, since I made such progress). I've been on just the other two, same schedule, since then--so far, for 7 months. He wants me to stick with this until September 2026 (but I haven't spoken with him about the new symptoms--next appt. is about 6 weeks away).
The past few weeks, my GI system has been giving me a lot of trouble (gas, nauseam, etc.), I have lots of body aches, I'm hot and cold... Now I know correlation doesn't mean causation--could be because I'm eating gluten (gave it up during Lent), or it could be hormones, or it could be lack of sleep, or it could be sloppy timing of when I take the antibiotics, due to my schedule of late. Also, my other meds don't seem to be working as well, which could point to poor absorption. I'm feeling too tired and to overloaded with work (full time) and school (accelerated doctorate) to go to the doctor (and my PCP justs retired). I take probiotics, when I remember to do so, but I read an article by a GI doc yesterday (in the WaPo) that said probiotics may not be a good thing (the article was about IBS, not antibiotics) and to focus on soluble fiber.
I think I just came here to whine - thanks for listening, but if this resonates with anyone... you're not the only one!

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@rc4mc - God bless you. I pray for us all. By the way, venting is a good thing.

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notnancy88 | @notnancy88 | Apr 28 8:18pm

There is research being conducted to use nanotechnology to attempt to penetrate the biofilm on mycobacteria. The biofilm protects the bacteria and makes it difficult for the drugs used to penetrate the cell wall. Let’s all hope for these researchers to discover a way for the antibiotics many of us are taking discover a way penetrate the Gram positive bacteria that thrive in our lungs.

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smc17 | @smc17 | Apr 29 5:59am
In reply to @irenea8 "@smc17 The only IV I have tried is Meropenem. Years ago I got C Diff from..." + (show)
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@smc17
The only IV I have tried is Meropenem. Years ago I got C Diff from an oral Ceftin. It is in the same class as the Cefipime so I would be wary. My GI is very reactive. But I might consider it. Thanks for letting me know. 2 months is sure longer than my one week of being better!

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@irenea8 I also have silent gerd that causes lung issues. I eat small amounts often but eat after my nebulizing and percussion vest. Its a real issue finding how to fit in all the lung clearance in a 24 hr day. Along with I reduced my work to 5 to 6 hrs days to give me more time for lung clearance.

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irenea8 | @irenea8 | Apr 29 6:58am
In reply to @fdixon63 "@irenea8 - Hi. After doing 2 weeks Ceftazidime via PICC my symptoms improve but it only..." + (show)
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@irenea8 - Hi. After doing 2 weeks Ceftazidime via PICC my symptoms improve but it only lasted a few months. The last time I did not have any inhaled antibiotic afterwards. This time we'll try Cayston. Is Merophnem an inhaled?? Just trying to stay hopeful.

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@fdixon63
I would be so happy if my improved symptoms lasted a few months. I would say that is successful treatment. Let me know how you do on the Cayston. Meropenem is an IV like Ceftazidime. It works like a miracle but once I finish the 2 weeks, the improvement only lasts one week and the infected looking mucus builds right back up! But the mucus is at least easier to expel for a longer period of time.

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