New antidepressant: Has anyone tried Auvelity?

@divinewisdom28, @colleenyoung This is an update on the Auvelity which I have been on for about 3 weeks. The side effect of nausea completely went away after a couple of days, but I find I have sort of a brain fog and sometimes feel wobbly when walking. I am hoping this will subside also, and it might not affect everyone this way. I'll keep you posted on that. As for its effectiveness, I can say that it has definitely helped. I am feeling much better and my mood is definitely elevated, however, I do not feel like my "normal" self, or should I say the way I feel when I have been on an antidepressant that is really working like I want it to, and the way I remember feeling on a normally good day long ago before I was affected by depression. It's hard to explain, but I think most of you will understand. As my psych doctor said, there is a little "uptick" you feel when an antidepressant starts to work, and I know exactly what he is talking about. A couple of years ago I started taking Trintellix. I had great hopes for it, as after taking it for a couple of weeks I definitely felt that "uptick" that he was talking about, and I felt better than I had in years. Unfortunately, that feeling only lasted a few weeks and then I was back to square one. Overall, I would say my reaction to Auvelity has been very good even though I have not felt that same "uptick".
Keep in mind that I am treatment resistant, and I mean I'm a really hard nut to crack when it comes to antidepressants, so I would encourage anyone to take it who has tried other things that have not worked. Don't let the high price scare you away, either, Auvelity is nothing more than 45 mg of Guaifenesin, a common cough suppressant that can be bought over the counter, and 105 mg of bupropion which is quite affordable. In fact, my doctor encouraged me to take it by combining those two drugs when my samples of Auvelity run out. I had taken both of those drugs before without success, but never together, so there does seem to be something to taking the combination of the two. On another very interesting note, there has been, at least for me, one very positive side effect.
I don't want to say that it is definitely from the Auvelity, as it could be attributed to another drug that I discontinued a few months ago in hopes of achieving this result. Last summer I was diagnosed with small fiber neuropathy which has changed my life drastically. (I am also on the neuropathy forum and I will post this there as soon as I am sure of what exactly has brought about this positive side effect.) Since last summer I have had severe itching, stinging, and burning sensations on my back, shoulders, arms, and chest, and I developed a severe sensitivity to fabrics. Just brushing the softest fabric across my arm would feel like sandpaper. There were a lot of things in my closet I couldn't even think about wearing, even though they felt soft to the touch. These symptoms were somewhat helped by gabapentin, the go-to drug for neuropathy, but it never helped as much as I would have liked for it to. Other pharmaceuticals were tried as well, but I had bad reactions to them. I would put body lotion on 5 or 6 times a day which would help temporarily by building up a barrier between the fabric and my skin. The neuropathy was always worse at night so getting comfortable enough to sleep was always very difficult. I could go on and on about how neuropathy has affected me, but for those of you who are not neuropathy sufferers, I'll get to the point, but I just wanted to give you some background information so you could have some idea just how miraculous this is for me. After taking the Auvelity for a few days the neuropathy symptoms started to dissipate, and after about a week they were completely gone! I cannot tell you what a miracle this has been for me! That in itself has lifted my mood. I just can't get over it, and if for no other reason I would stay on the Auvelity just to be rid of the neuropathy. As I said before, I will post this on the neuropathy forum, but I want to confer with my psych doctor and my primary care doctor, as there is a slight possibility that it could be attributed to a drug other than the Auvelity, and I am hoping I can narrow that down to a certainty of which one it is before I post it there.
So, that is my update on Auvelity. Again, I would recommend trying it if you've had trouble finding something that works for your depression. Best of luck to all of you, and may you be blessed with something positive every day of your life.

Auvelity. It's a combination of Wellbutrin and dextromorphin. I'm trying to get it prescribed.

Wouldn't it be a lot cheaper to just take generic Wellbutrin and buy DXM over-the-counter in a cough medicine?

I’m happy the DIY combo works well for some because it can be quite expensive to get the brand name Auvelity.
However I tried the DIY myself and it did not do anything for me above normal Wellbutrin, which I have been taking on and off for years. So I just wanted to throw it out there, it may be worth trying to get the brand name if you’re interested in trying it.

Personally I do not like Auvelity because I had very bad side effects. I am glad for people that find it helpful though. We don’t have enough things that really help people with mood disorders.

@ashleyharris728 what side effects did you have? I only have physical fatigue and it helps my gastrointestinal tract.