Connect
Anyone have testosterone replacement therapy (TRT) after ADT?
I had SBRT radiation treatment and stopped Orgovyx after 12 months.
After 2 1/2 months my T went up to 65 from a low of 8.
My oncologist says he is open to undergo TRT, but my RO says I should wait 12 months to consider TRT.
Fatigue is my main issue.
Like
Helpful
HugInterested in more discussions like this? Go to the Prostate Cancer Support Group.
Connect
@pesquallie
My Testosterone was 358 before treatment. It may be low but not bad at age 88! There is no data how TRT works for 90 plus people and side effects from TRT. My oncologist says IF cancer comes back, we will treat it. I am not ready yet to take that chance. What if when cancer back it is metastasized? He says we will zap it, meaning radiation if it is to the bone.
@ava11 Every case is different. Orgovyx has more rapid recovery than Lupron. Lower testosterone recovery occurs the longer you are on ADT and the older you are. If your testosterone has been stable for a few months further recovery is unlikely. When your doctors stopped ADT they had to assume testosterone recovery. You need to decide if the lifestyle gains of TRT outweigh recurrence risk.
@ava11
They not only zap radiation to the bone. They zap radiation to tissue like lymph nodes if they show Metastasis.
@stephenz, I moved your question to this related discussion so you can more easily connect with others who have considered testosterone replacement therapy after androgen deprivation therapy (ADT) for prostate cancer.
- Anyone have testosterone replacement therapy (TRT) after ADT?https://connect.mayoclinic.org/discussion/anyone-here-after-adt-undergone-trt/
@jeffmarc I’ve read research suggests trt works for a selective group of men.
Dr. Morgentaler concluded it is safe and effective in treating castrate-resistant prostate cancer, with around 30%–40% of patients experiencing positive responses. I haven’t seen any definitive information on which select sub group will be part of the 30-40%. How does one decide when the odds are less than 50%?
@lsk1000
if your PSA starts to rise significantly then it is probably not a good idea.
It can kill off the castrate resistant cells with the high dose of testosterone but the cells that aren't resistant can grow quick with the increased T.
If you have a genetic issue it may not be advisable. BRCA2 can really get accelerated growth so can other genetic problems.
-
Like -
Helpful -
Hug
1 ReactionThanks Jeff. Understood. So PSA still remains the go-to diagnostic metric.
@seasuite i’m just checking in to see how you’re doing now, what your testosterone level is and if your PSA is remaining undetectable or at least is still in a study state. I just started TRT last week after waiting one year after discontinuing ADT and remain remaining undetectable on PSA.
@robertmizek Well, I wish that I could report that all is 'hunky-dory' with my ADT side effects after TRT, however, I just stopped taking T-Gel since it was not effective for me. My initial T at 250 went to an acceptable 400 after 2 pumps per day. However, after close to a year, I didn't see an improvement in side effects (hot flashes, etc.) so I started tapering off. My T has been stable around 400 and no significant rise in PSA was detected. My urologist told me that TRT would, over time, reduce my ability to produce T naturally and, hearing that while seeing no positive effects, convinced me to stop. I am now pursuing a path with referrals to endocrinology, albeit, this is not the type of area they seem to know much about based on my early dealings.
I also plan to consider HCG that another PCa Bro. posted and raved about. https://connect.mayoclinic.org/discussion/hdc-alternative-to-t-supplement/
-
Like -
Helpful -
Hug
1 Reaction@brianjarvis I was 9 with two lesions on bones. I was really fatigued, bone joint sore, weak. Since my PSA is undetectable, he's letting me to stop Eligard and stay on Nubeqa.
-
Like -
Helpful -
Hug
1 Reaction