Anyone have testosterone replacement therapy (TRT) after ADT?

Posted by ava11 @ava11, Aug 4, 2025

I had SBRT radiation treatment and stopped Orgovyx after 12 months.
After 2 1/2 months my T went up to 65 from a low of 8.
My oncologist says he is open to undergo TRT, but my RO says I should wait 12 months to consider TRT.
Fatigue is my main issue.

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Profile picture for pesquallie @pesquallie

@ava11

I am in the same position after 12 months since my last 3-month Lupron shot. Increasing my testosterone level seems like the only way to get rid of the side effects. A lack of testosterone is what causes side effects since the ADT wore off many months ago.

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@pesquallie
My Testosterone was 358 before treatment. It may be low but not bad at age 88! There is no data how TRT works for 90 plus people and side effects from TRT. My oncologist says IF cancer comes back, we will treat it. I am not ready yet to take that chance. What if when cancer back it is metastasized? He says we will zap it, meaning radiation if it is to the bone.

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Profile picture for ava11 @ava11

@pesquallie
My Testosterone was 358 before treatment. It may be low but not bad at age 88! There is no data how TRT works for 90 plus people and side effects from TRT. My oncologist says IF cancer comes back, we will treat it. I am not ready yet to take that chance. What if when cancer back it is metastasized? He says we will zap it, meaning radiation if it is to the bone.

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@ava11 Every case is different. Orgovyx has more rapid recovery than Lupron. Lower testosterone recovery occurs the longer you are on ADT and the older you are. If your testosterone has been stable for a few months further recovery is unlikely. When your doctors stopped ADT they had to assume testosterone recovery. You need to decide if the lifestyle gains of TRT outweigh recurrence risk.

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Profile picture for ava11 @ava11

@pesquallie
My Testosterone was 358 before treatment. It may be low but not bad at age 88! There is no data how TRT works for 90 plus people and side effects from TRT. My oncologist says IF cancer comes back, we will treat it. I am not ready yet to take that chance. What if when cancer back it is metastasized? He says we will zap it, meaning radiation if it is to the bone.

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@ava11
They not only zap radiation to the bone. They zap radiation to tissue like lymph nodes if they show Metastasis.

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Profile picture for stephenz @stephenz

Has anyone selected Testosterone Replacement Therapy after ADT? If so, what were your results or recommendations?

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@stephenz, I moved your question to this related discussion so you can more easily connect with others who have considered testosterone replacement therapy after androgen deprivation therapy (ADT) for prostate cancer.

- Anyone have testosterone replacement therapy (TRT) after ADT?https://connect.mayoclinic.org/discussion/anyone-here-after-adt-undergone-trt/

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