Has anyone found a treatment that helps with peripheral neuropathy?

Posted by bigjohnscho @bigjohnscho, Jul 1, 2025

I suspect that everyone on this forum has been searching for a medication that helps their neuropathy and even though you no that all the internet claims are false we continue to waste hundreds of pounds. Desperation is a powerful force. Has any one been fortunate enough to find a genuine treatment. I just can’t believe that there are so many awful people who prey on our vulnerability and knowingly orchestrate such elaborate scams.

Interested in more discussions like this? Go to the Neuropathy Support Group.

Profile picture for sheilad1 @sheilad1

My husband has TERRIBLE neuropathy on the back of his thighs. We couldn't make social plans because he couldn't sit anywhere but on very soft leather, and even then it was terrible. Once a week or so he'd apologize for waking me but we had to change the sheet. The wrinkles were too painful.
CBD gave him his life back. He has a medical marijuana card and gets CBD capsules from Trulieve. It's remarkable.

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@sheilad1
I have my mm card and use Dr Solomon creams but they don't help with the leg burning. Which capsules does your husband find helpful?

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Profile picture for amanancy @amanancy

My doctor perscribed Baclofen and that has really tamped down the burning in my legs.

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@amanancy
One pain doc prescribed Baclofen a couple years ago for nerve pain, but I couldn't tolerate it and Pregabalin at the same time. I suppose it's possible to adjust to it over time, but I wasn't up to the task of finding out back then. Made me extra tired which I didn't need.

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Profile picture for bajjerfan @bajjerfan

@amanancy
One pain doc prescribed Baclofen a couple years ago for nerve pain, but I couldn't tolerate it and Pregabalin at the same time. I suppose it's possible to adjust to it over time, but I wasn't up to the task of finding out back then. Made me extra tired which I didn't need.

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@bajjerfan I take the baclofen in the morning, as it kept me awake at night. I take the Pregablin in the night before bed as it makes me drowsy. Only one. If I take two as perscribed I feel strange almost all day.

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Profile picture for amanancy @amanancy

@bajjerfan I take the baclofen in the morning, as it kept me awake at night. I take the Pregablin in the night before bed as it makes me drowsy. Only one. If I take two as perscribed I feel strange almost all day.

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@amanancy

I take PreGabalin 75mg 3 times a day. Morning, late afternoon and bed time.

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I put VapoRub on the bottom of my feet covered with a light socks st night. Have increased feeling in my feet

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Profile picture for barta42 @barta42

I put VapoRub on the bottom of my feet covered with a light socks st night. Have increased feeling in my feet

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@barta42

The PreGabalin relieves diabetic neuropathic pain on the left side of my chest and got rid of a lot of itching that would take over my whole body and got worse as the day and evening wore on. The tightness and numbness in my lower legs and feet seems to also get worse as the day wears on.

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Profile picture for jamessaxo @jamessaxo

@trooperdogg196
Yes. Take plenty of vitamin B12 in the form called METHYLCOBALAMIN.
B12 makes nerves insulation .

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@jamessaxo thank you. Ive been doing 5000 mcg og B12 Cyanocobalamin. Ill try your suggestion. Have a great weekend!

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Profile picture for lorry @lorry

Have you tested your vit B6 levels? B6 toxicity is now directly linked to PN.

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@lorry is B6 helpful or is it a cause of PN

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I do not believe that there is anything that will reverse the damage i.e. regenerate the nerves. However, at the suggestion of an internist who believed the PN to be idiopathic, I have been taking B-6, Folate and B-12 for years solely to hopefully prevent further damage to my nerves.

NB. I have not experienced pain just numbness.

I am considering adding B-1, or an equivalent, and possibly other supplements to enhance the effect of the above named supplements.

To improve balance I wear professionally created firm inserts (to address my congenital flat feet) and have finally found a pair of low profile hiking shoes that are comfortable, attractive and stabilizing. Together they have improved my balance and lessened the pain I have in one knee because of bone-on- bone. This has become my go-to pair of shoes for outdoor and indoor wear.

I also do balance exercises and never go bare foot.

Ted

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