High ISOPSA and PSA score?

Their is of course possibility PIRADS lesion/lesions might be found leading to an MRI fusion biopsy next up. I would expect the MRI is the MpMRI specifically for the prostate. On occasion you hear some urologist that just obtained a regular MRI. Certainly the numbers are concerning but would be helpful in context to have PSA history. The ISOPSA regardless of the MRI results along with your regular PSA jump warrant the biopsy regardless of MRI results. Now the numbers might be concerning but even if you did have cancer those numbers don’t infer how extensive it could be. Even if the ISOPSA infers more aggressive, it does not mean in anyway that it has spread or outside the capsule. Until a biopsy that is only way to definitively determine cancer and Gleason score. Few additional steps if you do move on to the biopsy is the PSMA-PET scan after that with also Decipher test. Plenty of options will be available . Good luck

Welcome and sorry you had to find your way here. It's really not time yet for concern. You don't have enough information to know what to be concerned about. But... I do predict a biopsy in your short-term future though, just based on the PSA jump. Best wishes and keep us informed.

The chemicals you were breathing and wearing, definitely could lead to prostate cancer. 7.7 as you probably know is high risk for prostate cancer, above six is high risk. Your PSA jump says the same thing.

Hopefully the MRI can find what’s there. It’s not always successful, sometimes people find the MRI may even find a tumor, but the cancer is somewhere else in the prostate.

I hope there’s nothing there but it’s unlikely. At least one thing you have to be comforted with is that prostate cancer doesn’t kill many people these days. It’s more of a chronic disease than a fatal disease. I’ve had it for 16 years and I’m BRCA2, which makes it much more aggressive. The drugs we have today work great and there’s new ones coming out all the time.

Consider a second MRI look either by another set of eyes (John Hopkins or Mayo) or with an AI look comparing thousands of other MRIs. Deepviewimaging.com provides the service. Register with them and have the facility forward the file to them. If unable to process the $259.00 fee is
waived for you or a third party payer. If later there is another MRI study they can review it and compare it with your own 1st over read also. They reduce the 2nd over read fee to $159.00. It provides another tile in the diagnostic mosaic guiding the clinicians.

@thmssllvn
I have the disc from my recent MRI which was performed with and without contrast. Getting to this company can be a form of a second opinion?
Please let me know! Thanks 🙏 ,
Carey

Did some research and was wonder how much further my concerns need be with this new information. I found the following from the National Firefighter Cancer Resource Center: Firefighters face an increased risk of prostate cancer compared to the general population, with studies suggesting they are diagnosed at a rate up to 1.21 times higher. This elevated risk is driven by exposure to carcinogens in smoke and firefighting foam, which can cause harmful changes to gene regulation (epigenetic modifications). Additionally my mom’s brother died of prostate cancer, and both my dad and his father had prostate cancer. I’m reading close family history increases the likelihood of cancer as well. Because of the triple whammy, does this increase my concerns? Please provide thoughts! Thanks 🙏,
Carey

@wheel1
I found that information I listed wasn’t fully accurate:
My PSA from 3/26 was 5.65
My PSA has gone from 2.2 to 5.65 over the last 6 years
My Total PSA 1st reading is 8.8
My ISOPSA is 7.7 and was my 1st reading.
Do these numbers make a difference?
Please let me know!
Thanks 🙏,
Carey

Unless things have changed DeepViewImaging.com does not use disks. Register with them first, then have the facility send the data files over. If for some reason they cannot process it they will
not apply the pre-authorized fee for $259.00 to you or a listed 3rd party payer. I am getting a follow-up MRI and they will compare it with my first MRI ( second read ) for $159.00.

PS: f/k/a PrecisionProstateConsulting.com

I would say at this point lets see the MRI report. If the report does not see things leading immediately to a biopsy decision. There are additional diagnostic tests, free PSA level, PSE blood test, and others that might still point to the biopsy. A focused biopsy is always better then just the random grid, but if it seems a biopsy is needed then go for it. I would certainly get another PSA test with free PSA also measured at maybe 45 days mid May if the MRI does not show anything.

@careyp Concern should be on family history. One first degree (father, brother) male relative with prostate cancer doubles the risk that you will have prostate cancer.
If the MRI shows some PIRADs of 4 or 5 that also points to likely cancer. PIRADs 2&3 can be but usually are not (< 1/3) cancer. PSA can change up to 20% depending on lab methods. If the PSA has shown a steady increase over the last 6 years, there is a good chance that there is at least low-grade cancer. Was the 8.8 reported with the ISOPSA (these tend to be on high side) or done at the same lab as the 5.65? Sex or bike riding within 48 hours before the test also increase PSA.