Considering Forteo

Posted by lisitabelle @lisitabelle, Feb 22 7:54am

Hello everyone,

My doctor would like me to start Forteo. I am 62 and have what is considered severe osteoporosis. It has been stable for many years and I have been treating it holistically (fit and exercise) and with Evista. Due to my age and underlying Panhypopituitarism (needing steroids for most my life) , my doctor is very concerned about my bones.

Has anybody used Forteo and how has that been? I am concerned about side effects and he mentioned that the black box warning of osteocarcinoma has been removed, but I still worry about that as well. It’s one of those things that I need to consider the benefits versus the negative side effects.

Thank you all so much for any information you may have.

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Profile picture for njx58 @njx58

@sodita Your doctor said that? That sounds like poor advice. Normally, if you don't follow up Forteo (or Tymlos) with a biphosphonate, you will lose the gains you made. Calcium and vitamin D aren't going to work.

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@njx58 I have been doing a lot of study of the importance of nutrition and specific exercise to build and maintain bone strength. This person’s doctor may be giving good advice. Algae based calcium and vitamin D with K are very important, along with other nutrients, for bone health.

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I am also 62 with osteoporosis in spine and neck. Hips are osteopenia but pretty close to osteoporosis. I tried Algaecal for almost a year and my numbers got worse. I am an avid exerciser, normal weight and have always eaten well. I finally went on Forteo April 2025. The only side effect I had was slight dizziness after injection for awhile. I go in this July for another bone scan so we'll see. I am a modern medicine believer but I also try natural if need be. I am also taking a Vitamin D-K supplement. I have friends and family on the estrogen patch and such, but I have early heart disease (a genetic cholesterol disorder that took a while to find out). Therefore, I am not a candidate. I wish you the best. Every person is different. I'm allergic to half the food and chemical planet. I say that facetiously, but I wasn't for years, and now I have GERD and ulcers. I follow the rules to a T. Hitting 60 was eye opening.

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Profile picture for lisitabelle @lisitabelle

@broken13 thank you so much for your help. Do you know if a drug like Evista can be taken instead of a a drug like reclast?

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@lisitabelle I think your doctor would be best to answer that for your individual case. From what I understand, reclast is stronger maintaining gains than Evista? I just had severe reaction to Bisphosphonates, so not wanting to go that route.

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How long can you take Forteo. 2 years and the a break and start again?

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sharonkhale, the most common use of Forteo is two years followed by a year or two or Reclast. Options have expanded but standards haven't been reset and research isn't being done. I'm finishing a third consecutive year of Forteo. My doctor says I should stay on this medication until my lowest T score is a -1, No one has figured out how low long you need to be off Forteo for it to be effective. The effects seems to lose the advantage for the bones after 18 to 24 months. If your doctor and your insurance are flexible you could end up on Forteo long term or in any pattern. Most likely you'll be prescribed the standard 2 year Forteo 2 year Reclast.
It is good if you can follow bone markers to understand if and how well the drug is working.

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Profile picture for gently @gently

sharonkhale, the most common use of Forteo is two years followed by a year or two or Reclast. Options have expanded but standards haven't been reset and research isn't being done. I'm finishing a third consecutive year of Forteo. My doctor says I should stay on this medication until my lowest T score is a -1, No one has figured out how low long you need to be off Forteo for it to be effective. The effects seems to lose the advantage for the bones after 18 to 24 months. If your doctor and your insurance are flexible you could end up on Forteo long term or in any pattern. Most likely you'll be prescribed the standard 2 year Forteo 2 year Reclast.
It is good if you can follow bone markers to understand if and how well the drug is working.

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@gently Thank you for all the information. You have obviously done a lot of research. I am hoping I can find a Dr who will try Forteo with me. I will work with a coach to get the right exercise and nutrition. My biggest challenge with this website is finding your latest post which was so informative! I am technically challenged.

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sharonkhale, if you tap on @gently wherever it is highlighted, you'll reach a profile page. Tapping on comments below the blue squared silhouette, you'll be regaled with too many of my posts or https://connect.mayoclinic.org/member/00-7c172167b26ffb93350352/. I always think it is better (easier) to ask again. I don't mind answering again, so answers can be revised because of new research and extended experience. I try to respond very specifically to what the poster is asking, which may make it cloying to anyone else's reading.
I am glad you are considering Forteo, and anticipate that it will be a good experience.

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Profile picture for cat1203 @cat1203

@nycmusic Not sure you can call this guidance but I can offer my own decision and why. I haven't started on Reclast yet but intend to when my Forteo is finished. Most people take Prolia or Reclast to chase an anabolic. Both can have very nasty side effects. I don't know if more people suffer bad side effects on one versus the other, but my sense is that most people don't have serious side effects on either. Maybe someone can point to studies that show otherwise. The main determinant for me is that I don't like that you can't just stop Prolia. You have to "wean" off of it by following up with a bisphosphonate like Reclast anyway. Otherwise you're at very high risk of suffering a fracture. It's called the rebound effect. The osteoclasts (bone "killers") are suppressed while you're on Prolia but when you stop they go into overdrive and you end up worse off than before (worse than baseline). You might need to stop because you might have side effects that you can't tolerate even if you don't have the worst ones. Or because your insurance no longer covers Prolia. Or because we have another pandemic like COVID and you can't even get in to see a doctor to administer it. Or or or ... who knows. But when you stop for whatever the reason, you HAVE to take a strong bisphosphonate afterwards. Then what if you can't tolerate the bisphosphonate?You're back to fracture risk. I've been on alendronate (bisphosphonate) before with no issues so I have a pretty high (perhaps misplaced?) confidence level that I would do OK on Reclast. To me going on Reclast for a year after Forteo (assuming I've had good gains and don't have to try another anabolic) is the shortest and safest route to the drug holiday that I hope to take. I'll have to monitor my bones with BTMs and DEXAs and go back on something eventually, most likely. But in the meantime I get a break (ha ha, hopefully not literally). Maybe when I'm 80 or 85 I'll change my mind and take Prolia if I'm going to be on it for the rest of my life and won't have to worry about transitioning off of it (and hope I don't have any intolerable side effects). It just seems to me to be a drug best left to later in life, if at all. I'm sure other people will have different opinions on that.

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@cat1203 thank you so much for all this information. I am starting Forteo soon and when you start reading some posts of people having issues on it… it is frightening. Thank you for sharing your experience and decisions on the follow up med options. My Dr. wants me to do Reclast after two years of Forteo. Praying this is the best option for me.

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Profile picture for broken13 @broken13

I also used Evista. Several compression fractures had me start Forteo in 2016. Did the full course of 24 months. Some initial side effects of tummy upset, leg cramps, slight dizzy after shot, so took it before bed. Great success and have not fractured since. Followed up with one shot of Prolia (did not go well) then Evista for 5 or so year. Now back on Forteo (Teriparatide) for a booster of 18 months and then will go back on Evista. I believe Forteo is one of the better bone building drugs on the market.

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@broken13
Thanks so much for your insight. I have a question… can Evista be used as a follow up to Forteo instead of a biophosphonate like Reclast? I have been on Evista for years and will be starting Forteo this week.
Thanks!

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Broken13, did you lose bmd in the five years on Evista? I'm curious if you had any side effects (or bone markers) since returning to teriparatide. I have heard that the second application of the drug is as "robust" as the first.
Thanks your answer is so perfect.

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