MGUS and GLP-1’s

I was diagnosed in 2021 and am also overweight- have increased exercise but weight is stubborn- still want to lose 20 lbs.
I have been stable mgus-wise where it is undetectable but want to do all I can to be healthy.
So also interested in your question.

I found some interesting research on GLP-1 meds and MGUS progression, at least for people that are type 2 diabetic. The research is early stage. https://pmc.ncbi.nlm.nih.gov/articles/PMC11643351/ https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.7559

Hi

I’m Dan and brand new to this site. I’m 72 and have been diagnosed with three serious conditions: MGUS, A-fib, and sleep apnea—all associated with being overweight.

I’ve lost 10 lbs on my own but am now seriously considering glp-1 treatment. My M-spike protein is 8, up from 7 six months ago.

I may be looking at summaries of the same data, but what I’ve found suggests that glp-1 and/or significant weight loss helps with all three conditions.

Anyone else here dealing with the same conditions and already on glp-1?

Thanks

@dand54 hi Dan! Welcome to Mayo clinic Connect. Six weeks ago I spoke with my generalist about the GLP-1s and she and I both looked data. My oncologist had also spoken to me about reducing dietary sugars and weight loss as this has been shown to positively impact overall health, of course. Obesity is thought to impact risk of progression from MGUS to multiple myeloma.
So we agreed that I should start Ozempic and work with the medication through diet and exercise to reduce my weight. I made it through the family Easter feast without gaining any weight but my weight loss to date has been minimal.
I also have type two diabetes, which is well controlled by medication and when I started taking Ozempic, I quit taking metformin. This would be a big plus if I can get off of that entirely.
This whole conversation is a good one to have with your physician. I had a productive talk with both my PCP as well as my hematologist/oncologist. Of course adding a medication is always a risk, but I’m hoping that if I can lose 30 pounds my numbers will go down. I’m very curious as to what others have to say about this who have been on the medication for a while. Will you let me know what you decide to do?

Hi Dan,
I tried Ozempic but had an adverse reaction. My doc feels it may be too dangerous to move forward with it. I started an exercise class and will try to do it without GLP-1s. Best of luck to you.

@pmm

Thanks for responding, Patty. My oncologist was dismissive and unhelpful. The others are generally supportive. Please keep me posted on your experiences. D

@ajbonett

Thanks. I’d love to do it naturally as well, but seems to get harder the older I get. Good luck. D

I lost 25 pounds over a year by doing plant based and before I eat mostly veggies ask myself is this healthy food! It also has stopped my IgG kappa going up beyond 2.eat veggies your body will thank you! There are great fake meatball that are tasty.