Is an HDL of 110 too high?

Posted by beaverstreefarm @beaverstreefarm, Jan 17, 2024

Is

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hello, curious if you ever learned more about your high HDL? My HDL came back at 109 on recent bloodwork, but LDL and Trig are very low. I read there may be some genetic disorders that could contribute to readings like this but there aren't really treatments available to lower HDL like there are statins for lowering LDL.

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Profile picture for floridaswan @floridaswan

hello, curious if you ever learned more about your high HDL? My HDL came back at 109 on recent bloodwork, but LDL and Trig are very low. I read there may be some genetic disorders that could contribute to readings like this but there aren't really treatments available to lower HDL like there are statins for lowering LDL.

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Hi @floridaswan, and welcome to Mayo Clinic Connect! It sounds like your initial lipid panel needs some digging into the weeds to learn more about what is unique to you. You bring great questions and no doubt will benefit from more detailed testing.

APOA1 is associated with HDL and a risk for atherosclerosis. Mayo Clinic lab details are linked here and you may want to review to understand how it may impact your individual risk, particularly the “Clinical Information” section.

-Mayo Clinic Laboratories Apolipoprotein A1, Serum Overview
https://www.mayocliniclabs.com/test-catalog/Overview/607591
My experience is that this testing helps my doctor understand how my unique body functions, helping to figure out how to treat it. This would be a fantastic place for you to go next now that you have found out your HDL cholesterol is high.

Do you have other risk factors such as poor lifestyle, smoking, diabetes, high blood pressure, etc.? Is this something you think your doctor is familiar with?

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I am not sure but I think fish oil supplements can raise it as well. My LDL was a little high and I was taking fish oil supplements. I stopped them and my LDL improved dramatically. There is evidence of this online in various articles as well. I take flax meal instead of fish oil. My HDL is always around 80-90s.

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Profile picture for Janell, Volunteer Mentor @jlharsh

Hi @floridaswan, and welcome to Mayo Clinic Connect! It sounds like your initial lipid panel needs some digging into the weeds to learn more about what is unique to you. You bring great questions and no doubt will benefit from more detailed testing.

APOA1 is associated with HDL and a risk for atherosclerosis. Mayo Clinic lab details are linked here and you may want to review to understand how it may impact your individual risk, particularly the “Clinical Information” section.

-Mayo Clinic Laboratories Apolipoprotein A1, Serum Overview
https://www.mayocliniclabs.com/test-catalog/Overview/607591
My experience is that this testing helps my doctor understand how my unique body functions, helping to figure out how to treat it. This would be a fantastic place for you to go next now that you have found out your HDL cholesterol is high.

Do you have other risk factors such as poor lifestyle, smoking, diabetes, high blood pressure, etc.? Is this something you think your doctor is familiar with?

Jump to this post

@jlharsh // Hello Janell - what a coincidence that you posted on Apo A1, I just had my annual physical with a new doctor and he tested it. I was unfamiliar with this marker and did some reading, this explanation was helpful:
https://lolahealth.com/blogs/longevity/apolipoprotein-a1-blood-test-normal-ranges-causes-what-your-results-mean
TL:DR version - high Apo A1 is better. The ApoB / Apo A1 ratio is also important, lower is better.

I was greatly relieved to have both very high Apo A1 (190 mg/dl) and a very low ratio (0.29), that suggests my health routines and medications are working (edit: in 2021 my CAC score was 1124)

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I always remember it like this HDL is happy cholesterol and LDL is lousy cholesterol. The happy cholesterol your HDL should be as high . That’s a wonderful score and your lousy cholesterol - The LDL- should be as low as possible and if added together and they are under 200 you are good to go!

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Profile picture for floridaswan @floridaswan

hello, curious if you ever learned more about your high HDL? My HDL came back at 109 on recent bloodwork, but LDL and Trig are very low. I read there may be some genetic disorders that could contribute to readings like this but there aren't really treatments available to lower HDL like there are statins for lowering LDL.

Jump to this post

@floridaswan no darling your scores are wonderful. You want your HDL to be as high as possible and your LDL to be low along with your triglycerides sounds like you’re doing fine!!!!

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Profile picture for l0lag0lag0b3 @l0lag0lag0b3

Hello beaverstreefarm
Recent test shows: HDL 90, LDL 52, Spoke to my Cardio, 1st question do you drink alcohol... my answer is NO + had a kidney transplant nearing 5 years before that I had a failing kidney ...On reading reading reading medical papers...there is some talk that excess use of olive oil & possibly coq10. In my case could be applicable.. not sure .. but have cut down Olive oil & Coq10 a bit & reduced my Cardio workouts to 4 days ... let's see how that goes.. yes there is a lot of talk of genetics being part of the cause. ideally HDL for seniors (me being in that group) is around the 60 from what is listed , This will be a discussion with my Cardio in upcoming meeting.

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@l0lag0lag0b3 that is not correct your HDL should be high. I wrote a message above saying how I remember it that it’s happy. The LDL I remember as lousy and that should be low. It sounds like you are perfectly in there for all the work you’re doing congratulations.

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Profile picture for whineboy @whineboy

@jlharsh // Hello Janell - what a coincidence that you posted on Apo A1, I just had my annual physical with a new doctor and he tested it. I was unfamiliar with this marker and did some reading, this explanation was helpful:
https://lolahealth.com/blogs/longevity/apolipoprotein-a1-blood-test-normal-ranges-causes-what-your-results-mean
TL:DR version - high Apo A1 is better. The ApoB / Apo A1 ratio is also important, lower is better.

I was greatly relieved to have both very high Apo A1 (190 mg/dl) and a very low ratio (0.29), that suggests my health routines and medications are working (edit: in 2021 my CAC score was 1124)

Jump to this post

Great news that you have excellent APOA1 levels, @whineboy!

What does your doctor have to say about your blood work, about your risk factors?

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