Mosunetuzumab vs Rituximab Clinical Trial for Follicular NHL

Posted by irene @irenekw, Feb 15 9:44am

Hello, I have untreated low tumor burden, grade 2, stage 3 follicular non-hogkins lymphoma. I have been on watch and wait since 10/2021 diagnosis. I would stay on w & w but the lymphoma is now in the palate bone of the roof of my mouth. I have been offered the phase III clinical trial comparing rituximab vs mosunetuzumab as a first line treatment.
Is anyone else in this study or considering being in this study?
Thank you ♡

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Lori, Volunteer Mentor | @loribmt | Feb 16 9:03am

Hi @irenekw. It looks like there’s been a little activity change in your follicular lymphoma (FL) moving from watch and wait to a treatment plan, which includes a potential clinical trial.

From my understanding mosunetuzumab (Lunsumio) has been approved previously (in 2022) for patients with refractory (relapsing) Follicular lymphoma. But the drug is now in a clinical trial as a first line treatment. Rituximab, alone or in combination with other meds, has been the gold standard for many years.

We have several members who have shared their FL stories. Looking through the discussions I haven’t run across the name Lunsumio (mosunetuzumab). But that doesn’t mean there aren’t members who have taken that medication. It can take time for replies to trickle in.

In the meantime here are a couple links for conversations with FL members. Please feel free to tag a member by clicking the blue reply button in the conversation box. That way they’ll be sure to see your quesiton.

~Starting bendamustine and Rituxan for follicular lymphoma, posted by @valandsheri
https://connect.mayoclinic.org/discussion/starting-bendamustine-and-rituxin-for-follicular-lymphoma/
~Follicular Lymphoma: looking to connect with others posted by @caracello22
https://connect.mayoclinic.org/discussion/follicular-lymphoma-at-age-44/
.
Irene, how are you feeling about the clinical trial? When do you have to begin treatment?

Colleen Young, Connect Director | @colleenyoung | Feb 26 7:31pm

@irenekw, did you decide to go on the trial? How are you doing?

irene | @irenekw | Feb 27 7:19am

In reply to @colleenyoung "@irenekw, did you decide to go on the trial? How are you doing?" + (show)

@colleenyoung they are waiting for an amendment to the clinical study to allow patients with autoimmune disease (like me) into the study. The other location has received the amendment, and they are hoping this location will receive it within 2 weeks. If not I will get another mri of the palate bone in my mouth and if the tumor has grown I will start rituximab mono therapy.

irene | @irenekw | Feb 27 7:23am

In reply to @loribmt "Hi @irenekw. It looks like there’s been a little activity change in your follicular lymphoma (FL)..." + (show)

@loribmt I feel confident with either treatment.

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