insight>>Lithium & Magnesium competition at enzymatic

Posted by pb50 @pb50, Feb 24 3:19pm

I have seen multiple references suggesting that Lithium and Magnesium ‘compete’ at an enzymatic level- which confused me. So I have been in search of insight. I am asking a lot of that biochem class in my quite distant past, but I figure I can get the gist.

Interesting article. Old, but I assume chemical interactions aren’t new either 🙂
https://pmc.ncbi.nlm.nih.gov/articles/PMC3805456/.

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pb50 | @pb50 | Feb 24 3:28pm

These insights / questions were sourced from springer nature

plus | @plus | Jun 15 11:07pm

In reply to @pb50 "These insights / questions were sourced from springer nature" + (show)

@pb50 "Long-term lithium" must surely apply to psychiatric LiC at massive doses. Wouldn't surprise me if LiO "micro" dose is an entirely different situation. My dim recollection of long ago (last week) reading last year's Harvard LiO study, is that unlike LiC it's easily metabolized without magnesium because it's binding to the neural MCI antagonist(s).

pb50 | @pb50 | Jun 16 6:51am

Cant be sure. But agree the most likely clinical population taking Lithium - albeit Lithium Carbonate - would be for bipolar treatment at much greater dosage.