Cranberry RCT study

@heavyphil Hi there: Studies show that exercising after a fast of 6-8 hours burns up the most sugar and fats, given that you hydrate well.
Thanks for the tip on the cranberry juice-I will mix it with our Aldi brand pomegranate plum juice, as the flavor is hard to beat.

@brianjarvis

My current prostate volume is 44.6ml. My current PSA result of 6.47 PSA indicates a PSA density of 0.145.

At my October 2023 diagnosis, my prostate volume was 43.5ml with a 7.8 PSA indicating a PSA density of 0.179.

My original Oct 2023 mpMRI found three lesions: one PIRAD 5 (2.2 x 1.1 cm), one PIRAD 4 (0.7 cm) and one PIRAD 3 (0.9 cm).

An Oct 2024 follow-up mpMRI found only one lesion (now 1.9 x 1.1 cm), while the other two were not visible.

My latest (Feb 20, 2026) mpMRI also only found one lesion, now rated PIRADS 4 and 1.1 x 0.4 cm.

My 12.3 year PSA doubling time, PSA density reduction from 0.179 to 0.145 and serial mpMRI lesion size reductions are all favorable for continuation of my active surveillance protocol.

@handera A PSA Density threshold of 0.15 (sometimes 0.20) or above is commonly used to trigger further investigation. Yours is borderline.

Regarding the MRI results —> October 2023 (3 lesions; PIRADS 3/4/5), October 2024 (1 lesion), and February 2026 (1 lesion; PIRADS 4). Have you had definitive confirmation on the status of those lesions?

With the changing number of lesions seen, have you obtained second opinions on those? A PIRADS score is a specialist’s educated and expert “opinion” of what he (or she) believes they see in an image - it’s often as much an art as it is a science. It’s always valuable to get 2nd opinions - especially with lesions disappearing. (Lesions don’t simply “disappear.”)

And the % Free PSA also provides valuable information as to what steps to do next.

@brianjarvis

Started with a new urologist last November, next appointment tomorrow, will see what he has to say about latest results. He was quite comfortable with my continuing AS, based on numbers and condition before latest results…which have just improved in the meantime.

I will not have another biopsy, due to suffering from Dysorgasmia for months after previous biopsy (lingering effects even 2.5 years later….I know, I know it’s rare….but personal experience trumps pablum medical SOC answers and the higher likelihood (in my case) for another Dysorgasmia reoccurrence in any subsequent biopsy, based on proven research.

I will be asking for the My Prostate Score 2.0 test (or possibly the PSE test)…it will be my only option to a biopsy….of course I’ll continue regular PSA and mpMRI’s….but no more biopsies…

I would be willing to submit to some form of advanced radiation therapy, if/when there is clear evidence of significant progression….but another biopsy is out of the question….therefore a second opinion, in my particular case, is moot.

BTW: Research indicates that MRI “lesions” often disappear for those diagnosed with low risk prostate cancer…it’s because they were originally only inflammation areas, which were misidentified as cancerous “lesions” in previous mpMRI’s…that’s what happened in my case…check out the research…

@jc76
I had been intermittent fasting for years, never eating breakfast and having 14 hours between meals. It certainly didn't stop my cancer development.

@stanjumper

…just curious….what was your Gleason score and Decipher score prior to getting treatment?

Gleason was 4+3=20 (Grade Group 3). The decipher was terrible being one. After 3 months if Eligard (Lupron) and one month on Orgovyx, my PSA has gone from 15 to .1. I hate the side effects, but it seems to be working. I just started Darolutimide last week.