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Reclast infusion side effects?

Osteoporosis & Bone Health | Last Active: 3 days ago | Replies (290)

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Hello,
I’m new to this forum.
I had a Reclast Infusion in May 2025. After a year dealing with knee pain issues my Dexa Scan results were terrible.
My endocrinologist had already suggested I’d need it, after doing some research I refused it for about 5 years.
Since the infusion, I’ve had digestive problems and pain on my left ribs. Strangely, on the first 24 hours after the infusion this is the exact place where I had intense sharp pain. It’s mostly during the night and in the morning.
Anyone experiencing the same?
Thank you!

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Replies to "Hello, I’m new to this forum. I had a Reclast Infusion in May 2025. After a..."

I trusted my doctor and had 3 infusions. Instead of feeling better, I fell the first year and broke 2 ribs on my left side, I thought well the medication had not had time to make a difference.
2 years later, being last summer, I tripped twice, been hospitalized twice, first time broke 3 ribs on my right side, a few months later, fell again broke 2 more ribs on my right side. I am very distraught and now it’s too late. Damage has been done 🥲 I just pray that I don’t break anymore parts of my body

penny57. I don't know if this is relevant to your situation. Reclast causes uveitis in some people because it excites inflammatory cytokines. Uveitis is often mistaken as an eye infection. Uveitis needs to be treated because it can cause permanent damage to vision. The treatment is ocular steroid. A five day oral steroid pack would relieve some of the pain you are experiencing in your joints.
You are so right about our need to take care of ourselves.
I hope you are feeling better soon.

After Reclast I have hurt worse than I did after back surgery! L3,4,5 laminectomy with fusion. Did great. Very little pain. With Reclast… sore, painful muscle aches, sore joints. Miserable and I’m a very active person. Walking, 5 yoga classes a week. Won’t do that again…. Plus the other side effects it could have!

Sorry for your suffering and hope you feel better….i just read that if a person has kidney issues, Reclast can cause serious damage….other OP meds not so much..it’s really hard to balance the needs of aging bones and aging kidneys !

Recently, I finished a year of Evenity and then had the first of two (once/year) Reclast infusions. Now I need a tooth extraction, which can lead to jaw necrosis, though the chances are low. Just wondering whether anyone else has had this come up and what your drs/dentists told you about it. One dentist said that once this stuff is in our system, whatever happens, happens. The endocrinologist says that the odds go down if I put as much time as possible between the Reclast and the extraction.
Thank you to everyone who has been posting. It's so true about taking one med. and finding out that while it fixes one thing, it causes something else!

2 weeks before I was due for Reclast infusion I learned I needed a tooth extracted and a bridge put in. The endocrinologist said to not reschedule Reclast until all the dental work was completed. I come from a family of dentists and dental hygienists. They have all told me NOT to do Reclast. Even the oral surgeon that extracted my tooth was lecturing me (angrily) on not doing it. I have a temporary bridge right now and soon getting the permanent one put in and I have had a lot of time to think about Reclast and decided against it. The risk isn't worth the reward bcz there doesn't seem to be any reward in doing it! When I first saw my endocrinologist she asked me if I had heartburn or stomach issues and bcz I said I had heartburn she said I have no option but to do the Reclast. I am weary of this response also. How bad are the oral meds for us folks with occasional heartburn? Are the endocrinologists told to push the Reclast on their patients?
I have a bone scan and appointment with endocrinologist in May and at that time I have to re-evaluate this whole situation. I am having a hard time believing that there is a medication that can restore bone health. Can anyone make me a believer?

There is no medication that can restore bone health. Period. The gain from Reclast is temporary. You can only have the infusion ONCE. Then the next year they will be pushing a different infusion while you're still reeling from the side effects of the first one. I've been there, my advice is don't do it.

Hello, I am new to this forum but have learned much from reading all the questions and comments. I am 75, small frame female and on my last scan, I dipped to -2.5 in the lumbar region. My primary care physician immediately said to start taking Fosamax. I am very hesitant to take this drug. I felt alone in this decision until I stumbled onto this group. I have not yet decided what to do.

pattwc,
Fosamax lowers bone turnover. The usual cause of osteoporosis is a lowering of bone turnover. Endocrinologist are questioning the wisdom of lowering bone turnover further when bone turnover is already lowered. The bisphosphonates don't trigger the growth of new bone; they collect older bone to increase bone density.
You might consider seeing an endocrinologist, or asking your primary for an anabolic medication like Forteo, which focuses on remodeling (increasing bone turnover) in the spine.
Or you might just decide keep it simple and take Fosamax from your doctor. While I'm not fond of the way Fosamax works, it does help prevent fracture, is less expensive and may be sufficient.
I sometimes wish that our PCPs and PAs were not prescribing osteoporosis drugs. Often they don't seem to have read the entire warning labels about side effects.
Welcome to the forum. I'm confident there is enough information here to guide your decision. And I hope if you have any questions, you'll present them for our varied responses.
Bless your bones.

As I have been posting on other pages…Reclast is very hard on kidneys…if you gave concerns—lab results out of range for kidneys—Reclast is not the med for you…good idea to research this issue, among others, while deciding what meds to take..