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Reclast infusion side effects?

Osteoporosis & Bone Health | Last Active: 3 days ago | Replies (290)

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Hello,
I’m new to this forum.
I had a Reclast Infusion in May 2025. After a year dealing with knee pain issues my Dexa Scan results were terrible.
My endocrinologist had already suggested I’d need it, after doing some research I refused it for about 5 years.
Since the infusion, I’ve had digestive problems and pain on my left ribs. Strangely, on the first 24 hours after the infusion this is the exact place where I had intense sharp pain. It’s mostly during the night and in the morning.
Anyone experiencing the same?
Thank you!

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Replies to "Hello, I’m new to this forum. I had a Reclast Infusion in May 2025. After a..."

Oh, it’s the ReClast! My side effects happened one day after the ReClast infusion. I had severe pain in my hip and thigh. This is evidently one of the known side effects that is considered acceptable. That stuff is poison. I still can’t walk any length without pain.
Best wishes for your recovery.

I had the reclast done a couple of years ago and maybe a few hours after I got home I was ok until I was getting up to go to the bathroom and I screamed in severe pain because I was now looking like a 90 year old women who was bend over at the waist and could not walk I had to have help and slide my feet to get to where I was going I was like this till the next day my husband couldn’t get me in the bed we tried for 30 minutes I cried and screamed till I had to go back on the sofa to sit and try to sleep it was like every bone in my bone had cracked and I couldn’t straighten up . When I called about what happened she could care less and said oh that’s normal well I lost it and had some choice words for her it was so painful and took almost a day or two to get upright I was looking at the floor all I needed was a hump in my back then u would really get what I was walking like . Never went back to her and never took what I call fentanyl and off the street crack cocain mixed together again . Got back on prolia hope no one has a story like this cause it was horrible ☹️

Margaret, my main concern is that Reclast carries a risk of atypical femur fracture, especially after years of use. These fracture can cause the type of pain you are experiencing for some long time before breakage.
While the bisphosphonates stay on the bone for many years, they are basically inert during attachment and cause pain only when encountering the cells that break down bone.
One pathologist said that he didn't think the bisphosphonate ever left the bone until it either encounters the osteoclast cell or until the bone around it breaks away in dissolution by osteoclasts. He said that bisphosphonate clads the bone in a mottled way clearly distinguishable from unclad bone.
The inert bisphosphonate shouldn't be causing pain. But if the bones were weakest in those areas zoledronate would accumulate there and you may be experiencing intense interaction between the drug and the osteoclasts. The length of time you have been on this medication puts you at greater risk for the atypical fracture. You should be able to get orders for the MRIs easily. X ray isn't sufficient.

Well if you read extensively about recast side effects it stays in your bones and body tissues etc for 10 years and can give severe bone pain anywhere in your body, hard to pinpoint that its recast doing it because most Dr and endocrinologist will deny that its a side effect of recast because they need to justify giving it to all us poor souls who got this 40 year diagnosis with low bone and no good treatments or reversals,etc because if they made a drug or treatment that cured us: they couldn't keep us dependent on the bulkshit horrible drugs the manufacturers had to make with disemregayd to how bad and how long term the side effects to ALL OF THESE OSTEO DRUGS ARE HORRIBLE BUT ALL THEY CARE ABOUT IS THEOR INCOME STREAM NOT GETTING SHUT OFF. I choose alendronate pill but now I've been on zepbound cuz I'm fat with low bone and its given me laryngeopharyngeeal reflux no cure either and can damage my esophagus from zepbound and fosamax shit to. Look up all the side effects from recast every different web site will give u more listed. GOOD RX HAS SOME AND INDEPENDENT OF TE DRIG MANUFACTURER WEB SITES : THE LATTER WILL GIVE U JUST THE TIP OF ICEBERG TO THE EFFECTS OF RECLAST IN THE BEGINNING AFTER INFUSION AND YEARS AND YEARS TO COME.. ENDOCRINOLOGISTS AND DRS WHO PRESCRIBE THESE HORRIBLE POISONS DO NOT TELL U THE WHOLE TRUTH. Im sorry u going thru this. DONT TELL U THE TRUTH. I hope u don't have any more bad things to it.

Hi did u see my post where I gave the telephone numbers and other directions to fill out a firm online at FDA Medwatch Portal go online search for that and ""report a problem" then select consumer/ Patient firm and fill it out or search for form 3500 B to fill it out online and send it to them or call 1-800-332-1088 to report side effects or mail letter with all pertinent info and request drugs be banned or taken off market or revamped to not cause jaw rot and atypical femur and hip fractures etc. Or send letter to FDA Medwatch Food and Drug administration at 5600 Fishers LANE Rockville Martmyland 20857-9787. IF THEY DONT RECEIVE THOUSANDS AND THOUSANDS OF THESE IN ANY WAY U CAN TO THEM: THEY WILL JUST IGNORE AND DO NOTHING. IT WILL TAKE ALL OF US BANDING TOGETHER TO DO THIS. MY NUMBER ONE OF THEM IN MY ORIGINAL PIST FOUND OUT AFTER I HIT SEND WAS A FAX NO. DONT CALL 1-800- 332- 0178 ITS A FAX USE THE 1-800-332-1088 NUMBER INSTEAD. THANK U. Remeber: THERE IS STRENGTH IN NUMBERS.