Morning "Hangover" from mirtazapine

@skim3737
Wow, thank you for the response. I went to the lower dose because if I were to get any bacterial respiratory issue mirtazapine is a contra indication to a Z pack and I thought if I had to stop it would be easier at the low dose. Will discuss with Dr.

@jgshoes
I'm so glad that I was able to give you information that may prove helpful to you. Definitely discuss it with your doctor, although the GI doctor who prescribed it to me in 2022 either didn't know or just didn't say anything to me about the higher dose causing less daytime drowsiness. It wasn't until I researched it myself after I was already off of it that I discovered it. And now 3 years later when my psychiatrist recommended it for my insomnia in place of my previous med, I was armed with the information to try the higher dose. Good luck to you and I hope that you're able to get some answers and relief!

Have changed from mirtazipine to amitriptyline. Will post results. First morning was better. Less hungover and less ruminations.

I have been taking 10 mg. of Amitriptyline for about 15 years, it was prescribed for pain and it helped a lot, I found that it had minimal benefit for my anxiety and depression but I always had difficulty adjusting to medication. A number of years ago I met with a cardiologist for rapid heart rate and he advised me to stop taking it because it caused increased heart beats, my doctor switched me over to Mirtazapine and from the beginning I had very nasty side effects, bad dreams when I could sleep, restless legs and a number of other symptoms so I stopped taking them after trying very hard to adapt but to no avail, I feel that it is like most drugs, they work really well for some people and not for others, the mission for me continues to find the right medication to help me.

TY! Am trying to figure out.

Dear Friends, Have been on 7.5 mg mirtazapine at night and now 25mg Paxil in the mornings with NO relief of very bad depression. Has anyone just stopped taking meds? All at once? One first then the other? Please LMK.
Thank you,
Jeff G.

@jgshoes, I feel that this would be a very difficult thing to do, also the side effects from withdrawal would be overwhelming for you. I understand your frustration with medication because I’m experiencing similar issues but I would never try this without the help from my doctor, both medications have to be weaned from and doing so at the same time could cause you harm, I understand depression and it can lead to poor choices, I too am trying a new antidepressant and the side effects are awful, I’ve come close to quitting them but I’m desperate for relief so I’ll give it some time, eventually I’ll stop if it doesn’t improve soon. If neither Paxil and Mirtazapine are not working then get help for proper withdrawal and then try something else, it’s a tedious process and not easy to deal with along with depression but I’m hopeful that there’s a light at the end of the tunnel, best of luck with your journey.

@frouke
Thank you for the thoughtful reply. My days are very difficult and sleep seems to be the best remedy. However, waking up from mirtazapine is a lloonngg process with lots of stumbling. I just started the 25 of paxil 1 week ago. I guess patience is in order here. Good luck on your journey.
JG