Has anyone else had emgality injections for migraines? Side effects?

Posted by lovelife4ever1 @lovelife4ever1, Nov 23, 2025

I have been on emgality injections for 3 months about to do my fourth one. I have had some side effects that my neuro dr says can't be from the injections. This is the only new med I have started in 4 months. Long story short, I have been very fatigue, high blood pressure, dizzy spells, ringing in the ears, and almost like sinusitis infection. About 2 weeks after first injection dr put me on antibiotics and steroids for a severe sinusitis infection and double ear infections. I felt better till I got the second injection now I have the same symptoms all the time some days or worse than others and some days are good. I also have back pain along with hand swelling for about a week to 2 weeks each time I get injections. My health insurance is very strict and my family dr has to refer me to specialist. What should I do or are these side effects normal. Yes my migraines are so much better than they were but I don't know if I can live with the side effects.

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Profile picture for suszy39 @suszy39

@bernieboy Got it. Medicare will only pay every four months on the Nerve shots. However, If the Botox would help every three months I will be happy to pay.

Warm
Regards

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@suszy39 Do It you won't be sorry.

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Profile picture for indyanthony @indyanthony

@mizbbd I take Emgality once a month and Propranolol twice a day, and I have been migraine free for a year! Emgality really helps me. I hope it helps you too!

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Hi @indyanthony - glad to hear you've been migraine free. What a relief.

Are you experiencing any side effects from the galcanezumab-gnlm (Emgality) or the propranolol?

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Profile picture for Lisa Lucier, Moderator @lisalucier

Hi @indyanthony - glad to hear you've been migraine free. What a relief.

Are you experiencing any side effects from the galcanezumab-gnlm (Emgality) or the propranolol?

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@lisalucier thankfully, no. It’s been going well!

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Profile picture for lovelife4ever1 @lovelife4ever1

@mrswhitt1 thank you for the information. Sorry you had to go through all of that. I'm going to say something again to my doctor because I can't keep living like this each day. Hope you are doing better now!

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@lovelife4ever1 - did you and your doctor end up talking about the galcanezumab (Emgality) injections and the side effects you were experiencing? If so, what did you decide about this treatment?

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So sorry, can anyone tell you if these side effects are from the injections. May I ask, did you try Aimovig before? It was working so well for 6 months but not so much anymore and my Neurologist has suggested changing to Emalvy (sp?)

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Profile picture for ellenblythe @ellenblythe

So sorry, can anyone tell you if these side effects are from the injections. May I ask, did you try Aimovig before? It was working so well for 6 months but not so much anymore and my Neurologist has suggested changing to Emalvy (sp?)

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@ellenblythe - Hi! Here is some Mayo Clinic information on the side effects of galcanezumab-gnlm (Emgality) injections:

- https://www.mayoclinic.org/drugs-supplements/galcanezumab-gnlm-subcutaneous-route/description/drg-20444084

Was this perhaps the medication the neurologist was suggesting changing you to, ubrogepant (Ubrelvy)?

- Ubrogepant https://www.mayoclinic.org/drugs-supplements/ubrogepant-oral-route/description/drg-20481621

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I had severe migraines for over 50 years. I tried everything with no results. My neurologist recommended trying Emgality. I did the injections monthly for twelve months with no side effects. That was 6 years ago and I can honestly say that I have not had a migraine since. What a game changer in my quality of life. I have recommended it to several migraine sufferers and so far all of them have had the same results. I understand that everybody is different and may not have the same results but my neighbor thanks me every time he sees me because it has changed his quality of life.

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My neurologist prescribed Emgality and I got no relief at all. We switched to Vyepti infusion every six months and game changer! I also take Benadryl or Claritin before I get it. Maybe taking something like a Benadryl beforehand would help.

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Profile picture for Lisa Lucier, Moderator @lisalucier

@ellenblythe - Hi! Here is some Mayo Clinic information on the side effects of galcanezumab-gnlm (Emgality) injections:

- https://www.mayoclinic.org/drugs-supplements/galcanezumab-gnlm-subcutaneous-route/description/drg-20444084

Was this perhaps the medication the neurologist was suggesting changing you to, ubrogepant (Ubrelvy)?

- Ubrogepant https://www.mayoclinic.org/drugs-supplements/ubrogepant-oral-route/description/drg-20481621

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@lisalucier Dear Lisa, i’m so sorry I did not get back to you sooner on your post. I’m appreciate this info and also I was out of the country for two months. I belong to at least two groups on this site. The two meds I was referring to are: Rizatriptan &Sumatriptan. my neurologist had prescribed these for active pain of a migraine headache —they did absolutely nothing. I am now on my second month of Emgality injections and so far it seems to be working. Well, the Amoivg worked very well for the first five months but after eight months, I don’t think they were working at all. most of the time when I get a migraine headache, I take butalbital, which works great for me and my primary care physician prescribes it. it is the only medication that works for pain, but my neurologist won’t prescribe it, which is a moot point I guess. He is totally against controlled substances. I think I explained this to another person on our site that he prescribed LDN to someone who later OD on it so he’s not even willing to try that for me . anyway it’s a difficult combination having what is called fibromyalgia and chronic migraine for well over 30 years now it’s just something that’s ongoing and if I feel I wanna make a change I’ll find somebody who will help me do that. after reading the links in your last post I do believe that I am having increased symptoms of Reynaulds syndrome as a result, perhaps, of using these injectables, however, I did have it before.

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