Brinsupri (aka Brensocatib)
FDA approved Brensocatib today. Hooray for us. Let’s hope we have access to it as soon as possible and it gives us some measure of relief. Thank you to all the scientists and doctors and patients!
https://www.multivu.com/insmed/9347351-en-fda-approves-brinsupri-brensocatib
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@lindabreathless
I read an article stating that some major insurers are scaling back advantage and part D plans fro 2026 and some people might lose their coverage if it is dropped in certain areas of the country. These changes are a response to financial pressures, including changes to government funding and rising healthcare costs. This has led insurance carriers to scale back their offerings in less profitable regions. I wonder if they will also scale back coverage of specialty drugs as well as dropping locations. Probably will.
CHMP Recommends EU Approval of BRINSUPRI™ Good news for our friends in the EU.https://investor.insmed.com/2025-10-17-CHMP-Recommends-EU-Approval-of-BRINSUPRI-TM-brensocatib-for-the-Treatment-of-Non-Cystic-Fibrosis-Bronchiectasis
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4 Reactions@irenea8 The possible problem is even when people and organizations make decisions that they think are good for them and us it 'ain't' necessarily so. That Drug out of pocket amount sounds great to us but it doesn't sound great to those providing the drug plans. As we know the Brinsupri is very costly and one of the factors that makes it hard for us and the drug companies providing the drug plans. What do you think, do you think that is part of it? The why of it as to why they are leaving areas or dropping coverages???
Barbara
Interesting that this drug comes to market at such a high price. Sure, the company negotiated rebates with insurers but those rates are negligible meaning insurance will pay more for the drug than it's worth.
@irenea8 I’m from Iowa, and have WellCare for my Part D coverage. No issues to get this drug accepted, Tier 5. I’m approved just this week, through 12/31/26. Then we get a new approval.
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1 Reaction@irenea8 just found this post from you by accident ... I am on Humira which treats a couple of autoimmune conditions. It is a specialty drug. It has kept me in remission for 7+ years. Just got a notice from my Aetna Medicare Advantage plan that they are taking it off their formulary for 2026 and suggesting we work with our doctors to transition to the "biosimilar" which came on the market a couple years ago at a fraction of the price. Humira is phenomenally expensive and I think I read it's one of the most profitable drugs in the world. My GI doctor's office had warned me that a lot of insurances are no longer covering it in 2026. So that's a long way of saying that yes, specialty drugs are being cut back. At least this one (Humira).
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1 Reaction@lvnl Here is a different viewpoint to consider.
Insurers and Medicare need to control costs when and where possible to avoid more premium increases. I know many people insurance companies believe are rich and can afford everything, but when I think about what my medical care and prescriptions cost, the $10,000 I pay in premiums and the $10,000 or so my employer contributes don't begin to cover the costs of my husband's & my care, even with the discounts the pharmacy benefit managers negotiate, and the limits Medicare places on charges.
Whenever there are generic or bio-equvalent drugs available we willingly try them. Nearly all have been fine and have saved both me and the company money. If they do not work after a reasonable trial, Blue Cross has made exceptions after sufficient documentation.
Similarly, when I wanted a faster nebulizer for my convenience, I didn't expect my insurance company to cover it. But, if I NEED it to dispense a specific drug, I'll fight for it.
Expensive specialty drugs like Brinsupri will need to demonstrate to insurers that they reduce primary medical expenses (like hospitalizations) in order to get onto their formularies or continue be covered.
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1 Reaction@sueinmn Would there be consideration for prevention - for the long term advantages of a drug like Brinsupri that reduces inflammation for those with worsening or more severe BE disease, and would presumably reduce risk of hospitalization or more urgent intensive care and other costly antibiotics for patients in the future?
Drug costs are high. It’s a bit shocking to hear the cost of a drug plan in the United States though, relative to other westernized countries.
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3 Reactions@sueinmn Thanks for spelling that out! I can get that that's how it works. I didn't mean to imply I object to switching to the biosimilar replacement for Humira. It's been well established as just as safe and effective. The cost of Humira is $77,000 annually in the U.S. and far less everywhere else in the world. That's the insane part.
@jnmy I can't say with regard too how Brinsupri will be handled long term. I can tell you that both my insurance company and my daughter's have pushed back against preventative therapy with certain meds. In my case, the doctor convinced them to change. In my daughter's case, her company would not budge and she is paying out-of-pocket using her HSA dollars.
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