I have an endometrial biopsy soon. What can I expect in terms of pain?

Posted by lexcampanella @lexcampanella, Sep 24, 2025

Hi there! I’m pre-menopausal and a colon cancer survivor. Once again, we got a pap result of abnormal cells….ugh. Anyway, I have a colposcopy and endometrial biopsy scheduled for 2 weeks. The scheduling nurse never said anything about pain levels. I’ve had colposcopies before and I know what to expect in terms of pain there (feels like they’re pulling my molars out through my cervix), but everything I read on medical sites regarding the endometrial biopsy says there will just be mild discomfort, some cramping, over in 5-10mins. I don’t really buy that cuz that’s what they said about a colonoscopy too and I found that was a lie right quick. What were your pain levels/experiences? Thank you for your time!

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It’s a disgrace that women should have to suffer through this procedure.
Imagine if a man had such probing and cutting into his genitals! You can be sure that the medical profession would use anesthesia and that insurance companies would cover the costs.
It’s maddening.

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I had an endometrial biopsy without any pain control. For me personally I thought it was uncomfortable, but quick . Yes it hurt, but only for a few seconds. They had to do it twice because they didn’t get enough tissue the first time.
I endured it just fine.
For me…uncomfortable, some moderate pain, but no big deal.

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I had several attempts over several years. The last was unsuccessful.
The cervix was to tight.
They gave me Tylenol beforehand. It was uncomfortable however only painful for seconds at a time.
Like terrible menstrual cramps. Next step was a D&C however I elected to have a total hysterectomy at this point. Tamoxifen for breast cancer caused my issue with a thickened endometrial
stripe. I asked at the very first problem for a hysterectomy. I was told by my GYN and Breast Oncologist to follow up closely. I said forget about a D&C...
I want everything out.
The gynecological oncologist surgeon agreed. Sure enough there was a small polyp with a 8mm clear cell carcinoma. In retrospect I am sorry that I did not demand surgery 4 years sooner.
I was 69 then. Don't know your circumstances however...a hysterectomy might be a consideration. ??
Out patient robotic surgery was easier than a dental implant! Good luck!

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Profile picture for jar1591927 @jar1591927

I had several attempts over several years. The last was unsuccessful.
The cervix was to tight.
They gave me Tylenol beforehand. It was uncomfortable however only painful for seconds at a time.
Like terrible menstrual cramps. Next step was a D&C however I elected to have a total hysterectomy at this point. Tamoxifen for breast cancer caused my issue with a thickened endometrial
stripe. I asked at the very first problem for a hysterectomy. I was told by my GYN and Breast Oncologist to follow up closely. I said forget about a D&C...
I want everything out.
The gynecological oncologist surgeon agreed. Sure enough there was a small polyp with a 8mm clear cell carcinoma. In retrospect I am sorry that I did not demand surgery 4 years sooner.
I was 69 then. Don't know your circumstances however...a hysterectomy might be a consideration. ??
Out patient robotic surgery was easier than a dental implant! Good luck!

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@jar1591927
What a great decision to have the hysterectomy! I was diagnosed with clear cell endometrial cancer in 2022 and it has been quite a journey. The robotic surgery was, as you said, surprisingly easy. Stay well!!

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I had the exact same experience as @elaine9. Two biopsies, the second because there wasn’t enough tissue from the first. No pain meds before. It was uncomfortable, but not excruciating. Some light cramping after.

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I had an endometrial biopsy decades ago and took no pain meds beforehand. I was told I would have
cramping and I did, but it was nothing unbearable, and it was over before I knew it. It went quickly
and I was so fortunate to have had it because they did find I had endometrial cancer.

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