ADT, maybe not? Anyone opted out of ADT?

@pesquallie Sorry.. what is BAT?

@tango32652
BAT is where you give people testosterone in order to try to reverse their becoming Resistant to ARPI drugs. When that happens, the PSA starts rising, even though they are on the drugs. In some cases, giving injections of testosterone for a few months can allow people to be able to use the ARPI drugs again. (Zytiga and the lutamides)

Here’s some further information though they claim this is new. This procedure has been around for a few decades.. I was offered it maybe five or six years ago as an option.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9313844/
Here is a link to a magazine that discusses BAT as well as a number of other issues prostate cancer patient would be quite interested in. First brought up by @vancouverislandhiker
https://online.flippingbook.com/view/150884930/

@jeffmarc As usual Jeff , very interesting ! The BAT concept is quite the thing . I was always told taking extra T at any point ( although im not on ADT ) , was like dumping gasoline on a fire ! So reading it , I had to read it three times ! Its appear BAT is successful on many . Great ! I hope it helps some people . Using Estradiol while on ADT is a new wave of discoveries Here is a web site to look at research . I know Dr. Richard quite well . https://estradiolinitiative.org/. Talk soon ! Although Im not on ADT maybe this will help someone ? James from Vancouver Island

@vancouverislandhiker
Not only that article but over at ancan.org You can search for Wassersug or estradiol There are a couple of videos done by Richard Wassersug PhD . He has written a book about using ADT and has himself been using estradiol for many years instead of ADT.

@jim99 Were you favorable intermediate. I was unfavorable intermediate and had 6 months of Orgovyx (April - September 2025). My PSA 3 months post-SBRT was 0.36 and 0.22 six months post.

I was unfavorable intermediate (Gleason 7, 4+3) and had SBRT but decided against ADT after reviewing other patients side effects reports and the article that I quoted that says there is very little benefit to ADT in my circumstances. My PSA is dropping much slower than yours but is still on a downward slope. I have had no side effects except a little urinary urgency which seems to come and go. Good luck.

@jim99
The use of hormone treatments is to starve the PC so that any treatment being done can benefit by stunting the growth of the PC.

That is a decision you have to make yourself which you did. Some want all the advantage they can get with successful treatment of PC and some see quality of life important.

If there was a magic want to determine how you will react to ADT it would be beneficial to you and everyone else as what I read is everyone reacts differently with different degrees of side affects. That goes for the same for side affects of radiation and or RP.

When you got your Gleason Score did you get a Decipher? That test is much more precise in determining your risk level of your PC. I always mentioned this in my posts as my initial Gleason Score rated me as intermediate. However my Decipher came back low risk. That changed my treatment plan from radiation and ADT to radiation only.

I had 3+4 and a decipher of .30. I opted for no ADT. Had a huge PSA bump that would have been invisible had I used ADT , the bump was temporary ( but concerning). If I had been 4+3 or high decipher I would have accepted 6 months of modern ADT.

@jeffmarc Yes, thanks Jeff and good point. Richard is the poster child for ADT with Estradiol , over 22 yes on it . He says ( Dr Wassersug) that controlling ADT with Estradiol is easier , less side effects and many other benefits for longevity . The Web site of https://estradiolinitiative.org/ is developing. They have meetings upcoming with Health Canada and others . Exciting curve if he can get approval on what he has been doing for at least 22 years ! James

@jeffmarc
all margins were clear also nothing in the lymph nodes or vesicles My doc said only 1 month

of ADT and 5 weeks of radiation with a 95 % rate of success. Been a week since my shot feels like they left the needle in my stomach. I guess i'm putting all my eggs in one basket.