ADT, maybe not? Anyone opted out of ADT?

@climateguy
You need to be careful when reading the Duke report because they use the term hormone when speaking of testosterone which technically is a hormone. It is confusing but based on the quote below they are saying that high doses of testosterone are best for aggressive difficult to treat prostate cancer.

"In recent years, clinicians have begun treating patients with late-stage, therapy resistant prostate cancers using a monthly, high-dose injection of testosterone in a technique called bi-polar androgen therapy, or BAT. The inability to understand how this intervention works has hindered its widespread adoption as a mainstream therapeutic approach for prostate cancer patients.

For the whole article see: https://corporate.dukehealth.org/news/study-solves-testosterones-paradoxical-effects-prostate-cancer

@pesquallie Testosterone, hormone and androgen are all the SAME in this article. ADT blocks all of them.
So in early disease, blocking T is beneficial…it stops the cancer…however, in late stage it can produce the OPPOSITE effect and promote its growth. This is why it is called contradictory because giving T to a late stage patient should make it worse, not better. But they’ve found that it does, indeed, work by forming an odd receptor site molecule that blocks its growth. It’s weird, paradoxical and makes no sense, but there it is…
Hope that clears it up…
Phil

@heavyphil

Phil,

Thankyou. I think you are right, but Duke has a hard sell because for 20 years doctors have been decreasing testosterone for aggressive cancer and their data shows some success. Duke is using AI to determine who this new BAT will help. It may be too late for me but it is great seeing that a lot of work is being done to improve treatments for prostate cancer.