Does anyone have advice on Letrozole?

I have been taking Letrozole for over a year. Thankfully, no reaction to it except an occasional face flush after taking the pill. I’d read about others who had serious reactions so was anxious about starting the medication. I’m older; wonder if it is easier with seniors for any reason??

I have been taking Letrozole for 15 months and have had no side effects except for dry eyes. I was 57 when I started taking it.

I've been taking letrozole for almost 9 months now. I'm not having any obvious side effects. My feet and ankles are really hurting lately, but that's probably because I'm very overweight. I've been dealing with elevated blood pressure, but medication changes seem to have stabilized that. I'm going to start a compounded glp-1, so hoping to get some of the weight off. It's hard to know if any of my symptoms are related to letrozole. I'm 65 and need to be on this for 10 years. Hope I can do it. Hope I can lose enough weight to feel better too.

whatever side affects you MIGHT have while taking Letrozole, the benefits way outweigh side affects. I took Letrozole after my first breast cancer (with a lumpectomy) way longer than doctors usually prescribe it, it just made me feel more "protected" ... and after finally stopping letrozole (after more than 10 years!) the breast cancer came back in the same breast about 4 years later! Yes, there were (& still are) some side affects - leg pain and weight gain for me - but I think the benefits of taking it far exceeded not taking it. I truly believe I wouldn't have developed breast cancer again if I had just stayed on the letrozole instead of taking the advice of my primary doctor. (and this time, I had a double masectomy, 2024, because I didn't want to deal with the possibility of breast cancer again)

@frenchtoasted429

@claunch
I'm 68 after terrible joint pain in both hands (permanent) I was put on Letrozole which developed its own side effects severe vaginal pain and uniary issues. Now on Exemestane which helped with Letrozole issues. However, caused pain in my upper teeth with dry mouth. Doctor has taken me off medication until my next visit. Has anyone experienced teeth pain? I did read that this is a side effect of exemestane.

I was on Exemestane for months and now my teeth are a mess. However, that wasn't the only AI I was on so not sure if this was the cause ofc my teeth problems. I now have a tooth that needs to be pulled as it is abscessed and I have to have a root canal. I have been on Exemestane, Anastrozole and now Letrozole. And, yes, I have heard that they all affect your teeth. They cause bone loss.....osteoporosis and osteopenia. I was also taking infusions of Zometa to help.....................obviously, it didn't.

@claunch, everyone reacts different to aromatase inhibitors, like Letrozole, Reading about the side effects that some people experience can make one anxious. I'm so glad that you gave it a try and reported that you are doing well on the medication. It helps to underline that everyone is different.

What type of breast cancer did you have? How are you doing now?

@colleenyoung, Infiltrating ductal carcinoma of upper outer quadrant of left female breast
Estrogen receptor positive status
1.5 centimeters

@claunch
I am doing well. But fatigue and some insomnia; the problem being, is this new or ongoing, from the past.