Anyone been prescribed Ohtuvayre (new med)? Your experience?

I started Ohtuvayre 7/24/25. No effect noted, but 8/8 I had an episode of severe epigastric pain, lasted a day. The next day it was gone but I was very tired, took things easy for a week and a half and lightened diet etc. Returned to rehab 8/23 but found my stamina was less, my heartrate was elevated, and didn't feel as well. I also found my shortness of breath had drastically gotten worse, to the point I could hardly walk from room to room without feeling breathless. Normally I only needed oxygen during the day with fairly heavy exertion. I was also exhausted, felt pressure in lung area and was starting to wheeze.

I continued to take the Ohtuvayre, but started looking online for info, and came upon this site. I saw that some other people had had a severe reaction as I was, and so on 9/18 I stopped the medication. Within three or four days my SOB subsided, energy level and heart rate improved and I felt much better. I'm back to my "normal" level of emphysema now. I have stage 4 and also pulmonary hypertension, but have done very well managing it with LTOT, Stiolto and good diet and exercise. Don't know why Ohtuvayre did not work for me, but I gave it eight weeks!

@kdny Have you shared the affects you had with it with Ohtuvayre? They want to know this information. You can go to Ohtuvayre.com or call 833-372-8492 which is the number for Verona Pharma Medical Information that is collecting all this information.

Yes, on 6 weeks. Crashed. Four days in hospital. More or less on old meds, back to normal. Not really definite was O2, but off. And never saw an effect of any kind.

All I can tell you is that a senior lung doctor who has been doing medical research for decades told me it’s essentially nebulized theophylline.

I never tried DUPIXENT,I have read about people using it & of course the Ads,I still use Trelegy Ellipta with Obtuvayre…

I started ohtuvayre today. I got a call that I will get to try it and since I have very good insurance I will have no charge. I was very surprised and very grateful. 🙏🏼
I am to still use Trelegy. I hope am not disappointed. I am a very social person so a lot is riding on this.

I too had a very positive initial reaction to Ohtuvayre but it was just for 1 day when I first took it and then I reverted back to the same level I was at. I have continued use for 30 days and may see some improvement but nothing significant. I’ll hang in there though and hope to see some change soon.

@rick33763
My doctor switched me from Trelegy to Breztri. It worked better and got down in my lower lungs because it is an aerosol. The Trelegy powder didn’t help my lower lungs. I’m hoping the Ohtuvayre helps me as well.