Success with low dose naltrexone for Autoimmune disorders

Hi everyone. I was diagnosed with GFAP autoimmune encephalitis in June 2024. My neurologist has prescribed high dose steroids to control the inflammation but reducing them proved difficult as I declined cognitively . Got stuck at 20mg and was starting with osteoporotic fractures. Neuro put me on Mycophenolate but that didn't work - reducing steroids had same effect - so the neuro increased the dose. My husband has done so much research and, among other things, identified LDN. I've been on it for 3 weeks now, starting at 0.5 mg increasing by 0.5mg each week. No negative side effects so far. I hardly dare breath it, but I think I have more energy and motivation (I'd forgotten how that felt), and I've started to reduce the steroids again and so far no negative cognitive impact. My advice? Give it a try as what have you got to lose?

Hi, I had to comment about the use of Naltrexone for autoimmune disorders. I’ve been on it for nearly six months. I really don’t know how effective it has been for modulating my overactive immune system, which was my reason for trying it. Time will tell. But every infection I had seemed to cause a new malady/disease. I had to take a chance. What I can report is that after starting Naltrexone my mood brightened considerably and my depression lifted. Apparently, I’ve been mostly depressed all my life and never connected the dots before. I hope the drug continues to work. As long as I keep feeling so emotionally positive I’ll stay on it for the rest of my life. I have no obvious side effects. Seems like a miracle drug for me.

Yes, a thousand times yes. I have been on it since 2019 and have no bad reactions to it. I started life with megraines and very hyper sensitive to every stimulus. I have several autoimmune diseases that LDN has helped and I am 79 now, so I must be doing something right.

LDN took about 3 months to make my Long COVID and constant, chronic inflammation a little better. Now at 4.5 mg per day and 8 months of LDN, My pain has lowered from a constant 7-8 to a 2-3 per day and my skin is clearing up. I have more energy and overall feel better...but it took a long time. This is one medication I recommend using for at least 3-5 months before you determine whether it works for you.

I started on LDN in August this year. I'm having some very good results with rheumatoid arthritis. My joints are at least 60% less stiff and painful. I don't hobble when I get up in the morning and I can lift my water kettle with one hand! I'm not as fatigued. My extremely dry mouth is better and I'm perspiring again.
I had previously tried methotrexate, hydroxychloroquine and Humira. I stopped those meds earlier this year so I would have an immune system for a cruise in UK.
I'm very thrilled by the results from LDN!

My LDN story -OMG and Hashimotos

I was diagnosed with Ocular Myasthenia Gravis in January. My symptoms included persistent double and blurry vision. I was prescribed Mestinon and this did help some with my DV. I have asthma and bronchiectasis. I was having difficulty with my breathing when I took enough Mestinon to help vision. My neurologist suggested adding steroids and several drugs that are immunosuppressants. I don't want to suppress my immune system. I want to support it. After doing some research I discovered LDN. My neurologist agreed to prescribe this. I stopped the Mestinon and started titrating LDN in May. I reached the normal optimal dose in August. On Sept 9 I realized that I went the whole day without double vision! I still experienced some blurry vision, usually later in the day or when tired. My neurologist agreed to have me bump up my LDN. I was taking LDN in the morning because of LDN causing insomnia. Now I take half in the AM and half early afternoon. After 3 weeks my blurred vision is gone as well!
Additionally I have Hashimotos. I have been taking Armour thyroid for several years. Since starting LDN my TPO and TgAb antibodies both dropped. As a bonus, my hair is no longer shedding!
Also my liver enzymes had been elevated and are now in the normal range.
I'm definitely a fan of LDN! It's worth the effort of pushing through temporary side effects like the headaches and finding the right time and dosage.

I use it too. I have two autoimmune conditions and I think it helps with inflammation.

I’m very excited to try LDN. Unfortunately the earliest appointment I can get with my pain doctor is January 2026. I have to exercise being patient! I have lupus, fibromyalgia, arthritis, ulcerative colitis, Barrett’s esophagus and adrenal insufficiency. I’m in pain 24x7 and constantly dizzy/foggy brained. I hate this!

Any kind of dr can script for LDN. You don't have to wait for your pain doc. Please let us know how it helps. I bet it does.

@ericamonique my neurologist prescribed it for me. You can also find online doctors who will prescribe ldn