Endometrial Cancer Stage IIIC1

Posted by mtstack @mtstack, Sep 6 10:17pm

Spotting in late April.
Referred to gynecologist after abnormal pap showing atypical glandular cells in June
Ultrasound showed endometrial lining thickened to 19.55mm
Collposcopy, scrape of cervix, and endometrial biopsy resulted in endometrial adenocarcinoma FIGO grade 3
Gynecologic consult Aug 4
Complete hysterectomy bilateral salpingo oopherectomy Aug 8
Pathology report: tumor in uterus, 97% invasion of myometrial lining, cancer cells in right sentinel pelvic lymphnode Stage IIIC1
Consult Sep 2: oncologist recommended platinum systemic therapy of six cycles of carboplatin and paclitaxel. Oncologist doesn’t recommend EBRT even though tumor board recommended a referral.

Anyone familiar with this stage and chemo treatment who might be able to share information on side effects. The more I read about chemo, the more I’m afraid to weaken my immune system. Seems like recurrence is likely and wondering about no further treatment?

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

Update after first cycle
Three sticks after first blew vein, second stick with different nurse almost blew and nurse gave up, to defer to most experienced nurse who succeeded!
So very late start for premeds.

Then taxol began and felt jittery on the IV arm, then flushed, then very dizzy, and heart started breathing wildly. So stopped after only 0. 7

Nurses gave me time to recover after giving me Benadryl. So confused why they have me Zyrtec in premed instead of Benadryl.

Finally called my oncologist who insisted I have Ativan or she said I would have the same allergic reaction. I was very skeptical bc she seemed to imply it would be better for me to sleep through the infusion. I felt like my body was screaming "No, don't put this toxic drug in my body".
It took me quite a while to decide to go ahead which what she "ordered". And the second time I stayed awake for the rest of the infusion in case something went wrong again.
Anybody else have allergic reaction to taxol or whatever it is I'm allergic to?

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Profile picture for mtstack @mtstack

Update after first cycle
Three sticks after first blew vein, second stick with different nurse almost blew and nurse gave up, to defer to most experienced nurse who succeeded!
So very late start for premeds.

Then taxol began and felt jittery on the IV arm, then flushed, then very dizzy, and heart started breathing wildly. So stopped after only 0. 7

Nurses gave me time to recover after giving me Benadryl. So confused why they have me Zyrtec in premed instead of Benadryl.

Finally called my oncologist who insisted I have Ativan or she said I would have the same allergic reaction. I was very skeptical bc she seemed to imply it would be better for me to sleep through the infusion. I felt like my body was screaming "No, don't put this toxic drug in my body".
It took me quite a while to decide to go ahead which what she "ordered". And the second time I stayed awake for the rest of the infusion in case something went wrong again.
Anybody else have allergic reaction to taxol or whatever it is I'm allergic to?

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I'm sorry to hear about all your chemo problems. That sounds really miserable.

They always gave me Benadryl as a premed. And for the first and second cycles the nurse sat in my little room for the first 5 min of the paclitaxel infusion and watched for infusion reactions. But I never reacted to paclitaxel. (I did eventually develop a horrible allergy to carboplatin, but that's a different story.)

To avoid the problems with finding a vein (and damaging them), you should get a port. They really do make getting chemo much less unpleasant. (I had my first two cycles of chemo through a vein, with multiple sticks, changing veins in the middle, etc., and then got a port. Big improvement.)

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Profile picture for Rhonda Crabtree @elaine9

Papillary serous endometrial and ovarian carcinoma stage 3. Had the complete hysterectomy. Taxol, Carbo, and immunotherapy with Herceptin.
If I had it all to do over again…I would do it all again in a heartbeat! Did my immunity get lowered? Yes, for a while. But through allowing time to heal, carful masking and no crowds, good vitamins, minerals, healthy diet and exercise…I’m healthy and enjoying life so much. I would say I am as close to my old self as I can be at my age with no ovaries or estrogen.
If this does reoccur, I will deal with it then. I do natural therapies with an integrative medicine doctor for now, so it keeps my spirits high as I feel proactive in my healing.
I hate that I live with the cancer cloud now, and chemotherapy was scary, and uncomfortable, sometimes there was pain, but it wasn’t nearly as bad as my imagination expected! Fear of the unknown is powerful. You will get through this.

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@elaine9 I could have written this. I am very interested in your experience. Would you be interested in talking through private messaging?
Denise

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I understand that about 40 percent of us are allergic to the binder in Taxol (castor oil), and are thereafter switched to Abraxane, which has the same drug but a more natural binder. I wound up in the emergency room overnight, but I consider that lucky, as the Abraxane infusion only takes an hour total (including flushing, etc), instead of the three I understand Taxol takes. That makes it much easier to ice your hands and feet to avoid neuropathy. I was given benydryl and dexamethasone (a steroid) before each infusion, which left me very comfortable. With a high quality diet and exercise, I had very few side effects from chemo and hope you will have the same experience. Good luck!

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I had a reaction to paclitaxel on my first chemo, but it happened after 24 hours. Benadryl took care of it. My 2nd chemo session, I had it in the chair. My nurse knew exactly what to do, so we just monitored after that. I did develop neuropathy in my hands and feet, which continues to be an issue 7 months later. Aside from that, I recovered very well after 6 cycles of chemo. My IVs were always in my hands, and yes, the veins there become irritated between the chemo and all the bloodwork needed, prior to each and after, to monitor hemoglobin, etc. I would say those veins are now back to normal. I hope you get ppl that know how to do an IV!!

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Profile picture for juliea55 @juliea55

I understand that about 40 percent of us are allergic to the binder in Taxol (castor oil), and are thereafter switched to Abraxane, which has the same drug but a more natural binder. I wound up in the emergency room overnight, but I consider that lucky, as the Abraxane infusion only takes an hour total (including flushing, etc), instead of the three I understand Taxol takes. That makes it much easier to ice your hands and feet to avoid neuropathy. I was given benydryl and dexamethasone (a steroid) before each infusion, which left me very comfortable. With a high quality diet and exercise, I had very few side effects from chemo and hope you will have the same experience. Good luck!

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@juliea55
Thank you for the suggestion. I'm so sorry you ended up in the emergency room overnight (assuming that was the reaction to taxol before switching to Abraxane.

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Profile picture for jeanknoll986 @jeanknoll986

I had a reaction to paclitaxel on my first chemo, but it happened after 24 hours. Benadryl took care of it. My 2nd chemo session, I had it in the chair. My nurse knew exactly what to do, so we just monitored after that. I did develop neuropathy in my hands and feet, which continues to be an issue 7 months later. Aside from that, I recovered very well after 6 cycles of chemo. My IVs were always in my hands, and yes, the veins there become irritated between the chemo and all the bloodwork needed, prior to each and after, to monitor hemoglobin, etc. I would say those veins are now back to normal. I hope you get ppl that know how to do an IV!!

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@jeanknoll986
Thank you.
Never heard of IVs in your hands. They were focused on my forearms whereas I had assumed they'd use the prominent vein in the crook of my arm but I guess that doesn't make sense for five hours of infusion.
I hope the neuropathy isn't too painful or bothersome seven months later.

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Profile picture for mtstack @mtstack

@jeanknoll986
Thank you.
Never heard of IVs in your hands. They were focused on my forearms whereas I had assumed they'd use the prominent vein in the crook of my arm but I guess that doesn't make sense for five hours of infusion.
I hope the neuropathy isn't too painful or bothersome seven months later.

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@mtstack I too expected the IV to go into my arm, but they told me that b/c of how powerful these cancer fighting drugs are, they have to use small veins and it has to go slowly. My chemo sessions were between 3 and 5 hours each time. As I also reacted to the one drug, they had to do the Benadryl by IV as well, and saline clean between each drug. It wasn't painful in any way...just a long session. We also had a 2 hour drive just to get to the hospital, so it was a lot of sitting. The patients also had a choice of lying down in beds, so I felt well looked after. I was also given a powerful anti nausea drug each time that worked until the 3rd day. Ask for anti nausea pills and take them!

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Profile picture for jeanknoll986 @jeanknoll986

@mtstack I too expected the IV to go into my arm, but they told me that b/c of how powerful these cancer fighting drugs are, they have to use small veins and it has to go slowly. My chemo sessions were between 3 and 5 hours each time. As I also reacted to the one drug, they had to do the Benadryl by IV as well, and saline clean between each drug. It wasn't painful in any way...just a long session. We also had a 2 hour drive just to get to the hospital, so it was a lot of sitting. The patients also had a choice of lying down in beds, so I felt well looked after. I was also given a powerful anti nausea drug each time that worked until the 3rd day. Ask for anti nausea pills and take them!

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@jeanknoll986
Thanks for the explanation about why they use the smaller veins. No one bothered to explain it.

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Profile picture for carol1024 @carol1024

I had exact same thing. Stage 3C. I had invasion and all that stuff too. Had hysterectomy on Aug 20th. Pathology report showed I was HER2+ which qualifies me for a more targeted drug. I'm starting Monday. Pathology also showed I was a stage 4 now.
My initial pap came back normal because cancer was behind the cervix. I did same chemo drugs you did too. I did immunotherapy with them. After I have 3 treatments and it looks like chemo is working, I will stop chemo and continue with immunotherapy. Getting morphine refill for the bone pain from the WBC booster shot. You should be fine if you have good immune system. I did the first chemo for 4 months and was not sick at all. I was just a little weak about day 4-5 and it lasted about 5 days. I got treatments every 3 weeks and I had about a week where I had energy before the next treatment. You'll do ok. Good luck.

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@carol1024
Did you end up stopping chemo and continuing with immunotherapy.
My molecular testing finally posted yesterday but I don't know how to interpret if immunotherapy or targeted therapy will be useful for me. I was looking for the POLE and didn't see it listed.

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