Rare serious side effect of Eliquis: Muscle weakness

Posted by cmauncc1 @cmauncc1, Dec 27, 2021

In late July 2017 I was admitted for very high heart rate and Afib. Had been, and still am, on minimal meds. Hospitalist put me on Eliquis, 5mg 2X/day.

Within a month my leg muscles were weakening to the point where I could no longer play Pickleball or walk golf. Within a few weeks my Cardiologist did an ablation and inserted a loop recorder. For the next 2-1/2 years the loop recorder saw MINIMAL Afib, under 0.5%; the ablation did its job.

By November 2017 I needed a walker. By December 2017 I needed to be wheelchair pushed through an Ice Sculpture display as there was no way I could walk the 25-30 minutes of the exhibit.

When I finally got to see a Neurologist at Shands (Univ of FL, Gainesville) in July 2018, he ran an extensive battery of blood work tests but could find nothing to explain the muscle weakness.

Has anyone else encountered similar muscle effects following being prescribed Eliquis?

Interested in more discussions like this? Go to the Heart Rhythm Conditions Support Group.

Profile picture for framagb @framagb

I was diagnosed with A-Fib Juy 8th. Started Eliquis & Aldactone, had cardioversion, now I am so fatigued I can barely function.
Eliquis???

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when meds make you worse, and almost all do, wean yourself off them. Examine your diet and what you can do to improve your health. I am NOT telling you what to do, but what I would do,,,, but in reality I would not have swallowed a pill without investigating the side effects.

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I am having muscle weakness where my legs will give out at the muscles above and below the knees. I can’t stand in one spot for a long time.
I do not have walking endurance.

I did not consider the Eliquis is causing this.

I am trying to get a referral to sports Medicine Internist who specializes in muscles.

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I am having muscle weakness where my legs will give out at the muscles above and below the knees. I can’t stand in one spot for a long time.
I do not have walking endurance.

I did not consider the Eliquis is causing this. But says 1% have this problem with Eliquis.

I am trying to get a referral to sports Medicine Internist who specializes in muscles.

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Profile picture for timely @timely

I am having muscle weakness where my legs will give out at the muscles above and below the knees. I can’t stand in one spot for a long time.
I do not have walking endurance.

I did not consider the Eliquis is causing this.

I am trying to get a referral to sports Medicine Internist who specializes in muscles.

Jump to this post

Within 1 day of starting Eliquis I went into Afib for the first time in a year. Then the fatigue, major gas and digestive problems and dementia like feelings and some scary thoughts. After 2 weeks I stopped taking it while arguing with the cardiologist who kept saying it was all in my head. Most issues went away within a week except for the massive gas bubble that continued to trigger Afib.
Still
Working on that without any real doctors help but it’s getting better. Eliquis is good for most people, but when it’s bad it’s BAD.

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My diagnosis of A-Fib was June, 2021 & the 1st med. Prescribed was Warfarin. That was Toxic Poison to me & Yes, it caused muscle weakness. After a lot of "Pushing", my Dr. switched to Eliquis. That worked for +- 6 months, then Side Effects popped up. After MORE "rankling", the Cardiologist changed me to Xeralto ...but within a Very Short period of time MORE terrible side effects. Finally (the 3rd Cardiologist consulted) I was told to Stop Everything, & see a Cardio-Surgeon. I'd been seeing an MD who believes if you take as Few Pharmaceuticals as possible, eat a Healthy Diet, & live an Active lifestyle, you should be healthy. He did blood tests & ordered a scan of my Carotid Artery. When we looked at it he said, "People Would KILL to have Arteries like yours. They are almost Plaque-Free. You Absolutely Don't Need Blood Thinners! I took this to my Cardiologist, She looked at the scan & said, "That doesn't mean A Thing" ... (My 'Common sense' Disputed her statement so I scheduled an Appt. with a Cardiologist (Who had been written up as one of The Best in the Area) 100 miles from my home, and saw him. He'd spent time looking thru my files (Lots of EKG's, test results, & Physicians emails) - Most Importantly the Carotid Artery Scan & Said, "Actually, the Only thing I could recommend is to take a small-dose aspirin every-other Day, eat a healthy diet - which it looks like you Already do, & get Exercise. I Wish More Patients like you could come visit me. I'd Really like to see you again in 6 months or a year, I'd Like to follow your health, potentially you could live to be 100".
After reading my story, I hope you'll listen to your 'inner voice' & exercise your Good Common Sense. When Dr.'s tell you something that Just Doesn't seem Right, Keep Asking Questions, even it it means consulting Another Doctor. Sooner or later one will come up with A Right Answer FOR YOU! (It's been said for Centuries: "Doctors Practice Medicine". Like Great Musicians they practice & Practice & PRACTICE 'till they finally Get It Right, & We're their Violins, or Pianos, or Trombones or Whatever! For Men: "It Takes A Lot of Practice to get Yankee Stadium!)

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Not as of yet I have been on Eliquis for z2 months . I know I am more tired than before. I am not trying to think of symptoms because I do need a blood thinner do to a blood clot removal from the brain do from AFib. More responses for how to handle Eliquis meds would be helpful.

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Just wanted to jump in quickly. :

Been on generic Eliquis for six years now... no probs at all tolerating it.

All the best!

/LarryG

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Eliquis nearly killed me. I had no Afib for 4 years then I started Eliquis and within 6 hours I was so sick and had such bad Afib I was cardio adverted. Then for the next 2 weeks I suffered dementia like feelings, horrible thoughts , severe head congestion and the thickest glue phlegm. So thick, I couldn’t breathe and major fatigue.
But the worst was the stomach massive gas in my chest that repeatedly trigger Afib. I stopped taking Eliquis on my own after arguing with the Dr. and within a day things started to get better. Except the stomach. It’s been 5 months and I’m just starting to get a handle on it. Drs don’t seem to want to help. They just want to prescribe more meds or ablation for Afib. But will they address the stomach NO!
It all started with Eliquis! I’m on a very low dose of Warafin now.
Acupuncture, Tapping, lymphatic massage and diaphragm breathing has helped a lot.

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Profile picture for moski @moski

Eliquis nearly killed me. I had no Afib for 4 years then I started Eliquis and within 6 hours I was so sick and had such bad Afib I was cardio adverted. Then for the next 2 weeks I suffered dementia like feelings, horrible thoughts , severe head congestion and the thickest glue phlegm. So thick, I couldn’t breathe and major fatigue.
But the worst was the stomach massive gas in my chest that repeatedly trigger Afib. I stopped taking Eliquis on my own after arguing with the Dr. and within a day things started to get better. Except the stomach. It’s been 5 months and I’m just starting to get a handle on it. Drs don’t seem to want to help. They just want to prescribe more meds or ablation for Afib. But will they address the stomach NO!
It all started with Eliquis! I’m on a very low dose of Warafin now.
Acupuncture, Tapping, lymphatic massage and diaphragm breathing has helped a lot.

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When you say drs don’t want to help are those drs here in Rochester?

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I’m in San Diego and I’m searching. I’ve joined 3 hospital chat groups trying to find answers and a Dr who will listen
I feel medicine now is about $.
The EP I just went to told me to not go to the ER. Because it costs the hospital $$.
When I said what? He corrected himself and said it costs me $$. If I feel my Afib and chest bubble are extreme and I’m willing to pay what’s the issue? He continued to say ride it out.

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