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Elevated Lp(a) levels - does Repatha help?

Posted by klaudiaarnold @klaudiaarnold, Jul 16 3:46am

Hi everyone,
After reading up on it myself, I found out there are hardly any medications available to lower highly elevated Lp(a)= levels. However, I came across Repatha and read that it might also help reduce Lp(a) levels. Is there any chance in significantly lowering an elevated Lp(a) level (above 50mg/dl) with Repatha?

• Has anyone had personal experience with Repatha to lower Lp(a)?
• And does anyone know a doctor who prescribes Repatha for lowering Lp(a)?

Thanks in advance for sharing your knowledge or experiences!

Interested in more discussions like this? Go to the Heart & Blood Health Support Group.

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loriesco | @loriesco | Jul 27 10:21am
In reply to @kisu "https://trials.lilly.com/en-US/trial/465595 (Copy and paste this internet address, URL) Type your zip code on the right side..." + (show)
Profile picture for kisu @kisu

https://trials.lilly.com/en-US/trial/465595 (Copy and paste this internet address, URL)
Type your zip code on the right side to see if there is a trial near you. Scroll down and answer the questions to see if you qualify.
"The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). ). Approximately 1700 additional participants will be enrolled in an addendum to explore Lp(a) lowering with an alternative dosing schema."
"Lilly's lepodisiran reduced levels of genetically inherited heart disease risk factor, lipoprotein(a), by nearly 94% from baseline at the highest tested dose in adults with elevated levels"

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Whoa! That looks amazing. Thanks for the share.

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westerly | @westerly | Jul 29 3:58pm

I'm a 72 year old male - with mitro valve prolapse - with moderate to severe leakage.
My overall cholesterol is 189 with a cholesterol ratio of 2.5 - so my numbers are good.
I am active in the gym three times a week - my HDL (Good Cholesterol) is 76.7
My cardiologist ran an Lp(a) test - my first ever - my score was 243 - anything over 75 is bad.
She wants me to start repatha. I am currently on 10mg daily of lipitor.
Thoughts?

Appreciated.

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1 reply
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loriesco | @loriesco | Jul 30 9:27am
In reply to @westerly "I'm a 72 year old male - with mitro valve prolapse - with moderate to severe..." + (show)
Profile picture for westerly @westerly

I'm a 72 year old male - with mitro valve prolapse - with moderate to severe leakage.
My overall cholesterol is 189 with a cholesterol ratio of 2.5 - so my numbers are good.
I am active in the gym three times a week - my HDL (Good Cholesterol) is 76.7
My cardiologist ran an Lp(a) test - my first ever - my score was 243 - anything over 75 is bad.
She wants me to start repatha. I am currently on 10mg daily of lipitor.
Thoughts?

Appreciated.

Jump to this post

I love my LEVQIO injections twice a year. I always tell the nurse it clears my sinuses and she laughs. I’m on year two and it really hasn’t done anything. My LPa is 66 to 88. My cholesterol is great and I continued to focus on diet and exercise. I can’t take statins because I get the muscle weakness and my dad took them for 25 years but it didn’t stop the plaque from laying down on his arteries. The numbers are there to tell you you have an issue and does not tell you necessarily the condition of your heart and arteries. A cardiologist has to interpret ALL the numbers and have pictures of your heart and arteries. Your age also has a bearing on the numbers.. Having a cardiologist is important because they will interpret all the puzzle pieces and give you an understanding and a regime to follow. Continue to do your own research so you can ask questions of the doctors team unfortunately the great numbers achieved when you control your blood serum, cholesterol, and lipids Are not indicative of what your body is actually doing. So it is helpful to understand the mechanisms of your body laying down plaque in your arteries. Keep up the good work where you can.

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paxlux | @paxlux | 1 day ago

I have been on Repatha for 2 months. My Lp(a) level dropped by 32%. I don't take any other cholesterol meds. My cholesterol dropped by 35%, LDL by 61%. Chol/HDL Ratio is now 1.7. No noticeable side effects. I hope this is helpful. My cardiologist prescribed it.

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Mentor
Janell, Volunteer Mentor | @jlharsh | 23 hours ago
In reply to @paxlux "I have been on Repatha for 2 months. My Lp(a) level dropped by 32%. I don't..." + (show)
Profile picture for paxlux @paxlux

I have been on Repatha for 2 months. My Lp(a) level dropped by 32%. I don't take any other cholesterol meds. My cholesterol dropped by 35%, LDL by 61%. Chol/HDL Ratio is now 1.7. No noticeable side effects. I hope this is helpful. My cardiologist prescribed it.

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Hi @paxlux, welcome to Mayo Clinic Connect. You have wonderful news to report about starting Repatha just 2 months ago! You must be beyond ecstatic about the drop in both your LDL and LP(a).

Since you are new here, would you share some about your health and what has led you to Repatha? Also, what type of follow-up will you have, when do you get numbers checked again?

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