Pregabalin & Gabapentin Not Working.

Thank you for your reply,I sincerely hope they can find a medication to help us all soon and also make it affordable,I have been on opioids for over 2 years and would love to come off it.

I started to develop PN in 2007, mostly losing feelings in my toes on both feet. By early 2012 my pain was so bad I could not wear socks nor have sheets touch my feet at night. By then I had tried all of the drugs, they all came with bad side effects and no relief. The only thing that helped was a low dose of Morphine. So in 2012 I had a Spinal Cord Stimulator implanted. It helped with the smaller nerves relieving about 60% of my pain. This allowed me to work snd get around better. Now it’s 2025, all my small nerves appear to be dead, no feeling in either feet with my large nerves causing pain. I do not use my Spinal Cord Stimulator. Not sure if this post helps, this is what happened to me.

I have halved cabamazepine which is similar to pregabalamin. Taking METHYLCOBALAMIN and turmeric. Alcohol and old age had reduced my B12 production . No pain and feeling 100 % . Stopped alcohol too.Look up , alcohol effect on B12 now. Go for it.

Yes indeed.

How do you wean yourself off a 10mg BuTec patch.

@mykitchencraft
I use a cream for my feet made by Kush creams.com
it is expensive but need only a very small amount #18315. Works for me , they have samples, give it a try/

Like everyone else I started out taking Gabapentin 300mg, then slowly increasing. Didn't really do anyhting at all to help. My doctor switched it to Lyrica (Pregabalin) starting at 75mg, then 150mg and now 200mg. This has helped a little, but it hasn't taken all the pain away or stopped the neuropathic jolts that I get. Not really sure on a percentage, but it has helped.

@insanepain I understand all of that, Gabapentin gave me headaches so I now take
450 mg Pregabalin and they say it’s a lot but once I added Amitriptyline it works better. I took it for years but wined off for other meds but now I’m back on because it’s the only medication that really works for me. They start you at 20 mg and build. I’m at 200mg again now. It has some side effects but really can’t tell because I already have those effects on their own without medication. Anyways Amitriptyline is very inexpensive which is a great benefit but can be tough to find your sweet spot through side effects and benefits. Hope you get some relief soon.

@mister1 Thanks. I will ask my painmanagement doctor about adding Amitriptyline. I was on Cymbolta, but that gave me headaches and made me nauseous so I stopped it. Good luck to you as well.

Try alpha lipoic acid 600 mg in morning - brand Source Naturals. It works for me - mine is idiopathic - plus good grade B complex vitamin.