1. < Gynecologic Cancers

Trastuzumab deruxtecan for endometrial cancer

Posted by cookercooker @cookercooker, May 29 9:25am

http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Trastuzumab%20deruxtecan_monograph.pdf,
a.k.a. Enhertu
https://www.enhertu.com/
Have been in a clinical study testing this target therapy for stage 3C serous cell endometrial cancer, and after 5 cycles it has shrunk my tumors considerably.

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

val64 | @val64 | May 29 10:14am

That's wonderful! Are you finding it tolerable?

I just started a clinical trial of a very similar drug (also an anti-HER2 antibody-drug conjugate with an irinotecan-like payload, but from a different company). My tumor had a +1 IHC score for HER2, which the original report called "negative", but apparently these "HER2 low" tumors often do respond to these drugs.

It remains to be seen whether my tumors respond. But I'm finding the drug to be very tolerable so far (knock on wood).

REPLY
1 reply
cookercooker | @cookercooker | May 29 11:19am
In reply to @val64 "That's wonderful! Are you finding it tolerable? I just started a clinical trial of a very..." + (show)
@val64

That's wonderful! Are you finding it tolerable?

I just started a clinical trial of a very similar drug (also an anti-HER2 antibody-drug conjugate with an irinotecan-like payload, but from a different company). My tumor had a +1 IHC score for HER2, which the original report called "negative", but apparently these "HER2 low" tumors often do respond to these drugs.

It remains to be seen whether my tumors respond. But I'm finding the drug to be very tolerable so far (knock on wood).

Jump to this post

I'm HER2 positive. The drug is tolerable if I take my anti-nausea pills and and anti-heartburn pills. I had developed peripheral neuropathy while on carboplatin/paclitixal previously and find that while it hasn't gotten worse, it is still there.
How many cycle have you had already?

REPLY
1 reply
val64 | @val64 | May 29 2:31pm
In reply to @cookercooker "I'm HER2 positive. The drug is tolerable if I take my anti-nausea pills and and anti-heartburn..." + (show)
@cookercooker

I'm HER2 positive. The drug is tolerable if I take my anti-nausea pills and and anti-heartburn pills. I had developed peripheral neuropathy while on carboplatin/paclitixal previously and find that while it hasn't gotten worse, it is still there.
How many cycle have you had already?

Jump to this post

I just started cycle 1 ten days ago. Had a bit of acid reflux for the first few days. Took an antacid on the day after infusion, but nothing since.

My feet are somewhat numb from my first round of carbo/taxol 2.5 years ago. That hasn't improved, even during most of a year completely off treatment. I'm not expecting it ever to improve.

REPLY
1 reply
cookercooker | @cookercooker | May 29 6:11pm
In reply to @val64 "I just started cycle 1 ten days ago. Had a bit of acid reflux for the..." + (show)
@val64

I just started cycle 1 ten days ago. Had a bit of acid reflux for the first few days. Took an antacid on the day after infusion, but nothing since.

My feet are somewhat numb from my first round of carbo/taxol 2.5 years ago. That hasn't improved, even during most of a year completely off treatment. I'm not expecting it ever to improve.

Jump to this post

Me neither. Bummer.

REPLY
Mentor
Helen, Volunteer Mentor | @naturegirl5 | May 29 7:55pm

@cookercooker Bravo, this is very good news.

REPLY
Please sign in or register to post a reply.