Anyone familiar with the clinical trial RMC-6236? Or how to enroll?

I did the combo trial, 9805 with 6236. It had immediate effects and for nsclc it is having wonderful results based on a thread I am in for these drugs. The side effects of 6236 are also immediate. Scalp sores/scabs, face breakout, nail bed infections, and mouth sores.

I did not have any progression for 6 months. The progression I did have was in a watched area and a small nodule in my lung.

If they can get a handle on the severe skin problems and couple it with the right dosage and type of chemo, I believe it will be a stabilizer .

Many come off of it because of the severe skin issues. Hope this helps. I was in phase 1b. If you are doing this trial, proactively ask for skin remedies besides doxycycline.

I did both RM 9805 and 6236 for 7 months. Can discuss side effects, etc if anyone is interested.

Phase 3 trial in progress now couples 6236 with standards of care.

I did both RM 9805 and 6236 for 7 months. Can discuss side effects, etc if anyone is interested.

Phase 3 trial in progress now couples 6236 with standards of care.

I did both RM 9805 and 6236 for 7 months. Can discuss side effects, etc if anyone is interested.

Phase 3 trial in progress now couples 6236 with standards of care.

Would you still be willing to discuss your experience with 9805 and 6236? Where did you receive your clinical trial?
Thank you and have a blessed day 🙂
Sandy

Yes, I am very familiar with this trial. RMC-6236 is a unique drug compound designed to be a “pan”-KRAS targeted therapy meaning it is potentially capable to target several of the KRAS variants-not just a single one.

Here is the link to the trial descriptor, all the sites currently recruiting and the contact phone and e-mail of the trial sponsor. Look for a site near you that indicates recruitment is open. Do a Google search of the institution and for the link to clinical trials. Once in that section of the facilities’ website where all trials are listed, search for RMC-6236. It will give you the contact info for the principal investigator (P.I.) and the clinical trial nurse coordinator. If you have difficulty finding this information, contact the Pancreatic Cancer Action Network (PanCan.org) at 877.272.6226, M-F, 7:00am-5:00pm PT. Speak to a case manager who can look up contact info for the RMC-6236 clinical trial.

There is a lot of interest in this trial because 90% of pancreatic cancers are linked to a KRAS somatic mutation. That means each site likely will meet their accrual quota quickly. I suggest you obtain your complete medical records and follow through quickly if you are interested in participating in this clinical trial. They key pieces of information a P.I. will need to determine eligibility are: Cellular Pathology report confirming specific diagnosis, a surgical pathology report if surgery was performed, Radiologist interpretations of current and prior imaging (CT or MRI), copies on CD or the imaging, current blood chemistry and hematology reports. Chemotherapy log detailed administration of each chemo cycles, drugs used and concentrations. Most of this will be available on your patient portal and can be downloaded and sent as a pdf file. If you were not requesting copies of your imaging at the time they were done, then you will need to contact the medical records department to obtain them. The chemo administration log likely will not be in the patient portal. Contact your N.P. who can obtain that file which is usually in the form of an Excel spread sheet.

Do you have any further updates and/or opinions on these drugs now that it is in Phase 3? Very much appreciated.
Sandy