I did the combo trial, 9805 with 6236. It had immediate effects and for nsclc it is having wonderful results based on a thread I am in for these drugs. The side effects of 6236 are also immediate. Scalp sores/scabs, face breakout, nail bed infections, and mouth sores.

I did not have any progression for 6 months. The progression I did have was in a watched area and a small nodule in my lung.

If they can get a handle on the severe skin problems and couple it with the right dosage and type of chemo, I believe it will be a stabilizer .

Many come off of it because of the severe skin issues. Hope this helps. I was in phase 1b. If you are doing this trial, proactively ask for skin remedies besides doxycycline.