Does anyone have a solution to help manage Reclast side effects?

Eventually I was able to view and print it out!
I do hope it is okay to share here! Thank You for sharing this with me!

Immune-mediated syndromes following intravenous bisphosphonate therapy
Reclast infusion
https://link.springer.com/article/10.1007/s10787-017-0365-9
Abstract
Objectives
Intravenous (IV) infusion of aminobisphosphonates (ABP) induces cytokine release by peripheral blood Vγ9δ2 T cells, resulting in an immediate short-term inflammatory response in up to 50% of patients. We evaluated possible long-term pro-inflammatory effects of IV ABP.
Methods
Retrospective case-series study from one rheumatology specialist’s clinic. 2261 electronic charts were reviewed for administration of ‘zoledronate’ or different brand names of zoledronic acid, and relevant clinical data was retrieved for patients who had received the infusion.
Results
Thirteen patients had recieved zoledronate. In six, new-onset or exacerbation of a previous inflammatory/autoimmune disorder was diagnosed within 3 months following infusion. Of these, one patient developed new-onset rheumatoid arthritis (RA), two polymyalgia rheumatica (PMR), two suffered a flare of Crohn’s disease-related and aromatase inhibitor-induced arthralgias, and one patient acquired autoimmune hemophilia. Pre-existing malignancy and immediate inflammatory response following zoledronate were more frequent in patients experiencing new or worsening immunologic manifestations (3/6 vs. 0/7, and 5/6 vs. 2/7, respectively).
Conclusions
Intravenous ABP may trigger induction of persistent autoimmune syndromes, especially when accompanied by an immediate adverse reaction or pre-existing malignancy.

It is all from the infusion
My bones are inflamed because of the remodeling caused by Reclast
My endocrinologist says she is very sorry, is one case in a million!!
Well I am that one case and my life has been turned upside down
My pain is in the bones of my left femur and my ribs
I can’t sleep or function
After all kind of testing they determined it is not my heart
My misery is the same
I wish it was a heart attack and be done with it, but no I have to live with these side effects
I sympathize with you

Please, do not give up! I’ve been going to physical therapy and it has been helping some! You now know that it is not from an injury! And, because of this you can make it get better over time. I try to stay as active as possible and do try to keep up with my exercise! My worst is now my left foot and sleep! I am better able to handle the pain in my shoulders throughout the day but at night, the smallest move and my shoulder pain wakes me right up. I am able to go back to sleep despite my sleep being disrupted by the pain. It takes some ambition on my part and I am not going to allow this medication to ruin my total life! Stay positive and it will get some better, hopefully completely better with time. In the meantime, No more bone density medication for me!

I also was provided this by a person on here!

Immune-mediated syndromes following intravenous bisphosphonate therapy
Reclast infusion
https://link.springer.com/article/10.1007/s10787-017-0365-9
Abstract
Objectives
Intravenous (IV) infusion of aminobisphosphonates (ABP) induces cytokine release by peripheral blood Vγ9δ2 T cells, resulting in an immediate short-term inflammatory response in up to 50% of patients. We evaluated possible long-term pro-inflammatory effects of IV ABP.
Methods
Retrospective case-series study from one rheumatology specialist’s clinic. 2261 electronic charts were reviewed for administration of ‘zoledronate’ or different brand names of zoledronic acid, and relevant clinical data was retrieved for patients who had received the infusion.
Results
Thirteen patients had recieved zoledronate. In six, new-onset or exacerbation of a previous inflammatory/autoimmune disorder was diagnosed within 3 months following infusion. Of these, one patient developed new-onset rheumatoid arthritis (RA), two polymyalgia rheumatica (PMR), two suffered a flare of Crohn’s disease-related and aromatase inhibitor-induced arthralgias, and one patient acquired autoimmune hemophilia. Pre-existing malignancy and immediate inflammatory response following zoledronate were more frequent in patients experiencing new or worsening immunologic manifestations (3/6 vs. 0/7, and 5/6 vs. 2/7, respectively).
Conclusions
Intravenous ABP may trigger induction of persistent autoimmune syndromes, especially when accompanied by an immediate adverse reaction or pre-existing malignancy.

I had the Reclast injections in Nov. 2024, and symptoms started soon after. Within 2 months my osteoporosis doc told me my labs showed RA and anemia (remotely tested for RF previously- was negative); have hand/wrist/finger swelling, pain, ankle swelling/stiffness, and fatigue. Anyone with a similar situation? I was told to go back to my PC (who doesn’t even know I had the infusion) for help with the anemia. Osteoporosis doc wants me to consider Methotrexate.

My friend (who had Prolia injections x2) said her rheumatologist said Reclast is not a good choice for older people, and he would not use it for them (my friend is 73).

@ dannyandebbie
I already have rheumatoid arthritis and my endocrinologist recommended Reclast because I am unable to take the oral medication due to GERD.

I’m terrified to take this medication and also am hesitant because I am scared to death of the dentist and haven’t been to one in a few years. I know it can mess up your jaw if I’d require dental work/surgery if I had the infusion. Anyone know of a different medication (not oral) that doesn’t have as many concerning side effects? I’m also 70 years old.

Are you doing your own research on osteoporosis meds? Why is your endocrinologist chosen reclast? I have no recommendations about which meds are appropriate for you because I am not a doctor but I think it is always wise to do your own research so that you can engage with your doc about the rational and also to discuss drug sequencing with some sort of long term plan. Good luck

I have just started doing my research on Reclast because that is what the endocrinologist I saw is recommending. She told me at the end of the visit that I have to something. I have had osteoporosis for years. I am in my 70’s.
My DEXA scores have been pretty much the same. I have a healthy diet, use the treadmill 5 days a week, work with resistance bands, do balance exercises, etc. I know my PCP wants me on Reclast because she has seen too many active senior break a hip and end up in a nursing home.

I posted previously that I am now AFIB free after being diagnosed in 2013. I sent a message to the endo doc asking if she could share any current studies on Reclast and AFIB. She gave me a long explanation, but no studies. This doctor was not recommended to me. I just looked at her bio and it sounded like she would listen and be open minded. I go to a large teaching hospital. She is on the faculty there and is a Castle Connolly Top Doctor, for whatever that is worth. I am not switching doctors, because without a recommendation, I would be just pulling another name “out of the hat”.

I am thinking about reaching out to a clinical pharmacist in the endocrinology clinic. That person may be able to help with some of my questIons. Have any of you used this avenue as a resource?

I just told my husband I am sick of doing all this research!!! I am an over thinker! In addition to that, I have an anxiety disorder!! I am taking a “research”break this weekend. In saying that, though, I am sure I will be adding a few more things to my Reclast to do/questions list.

lee1477
First to answer your question. Definitely call the clinical pharmacist. They are usually (unusually) well informed.
No reading until Monday. Happy Mother's Day
https://www.sciencedirect.com/science/article/abs/pii/S0049017223001464