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Brensocatib Aspen Trial Results in NEJM!
This diagram — “Neutrophils: Defender and Offender” — is what Dr. Chalmers often refers to as a “confusagram” (I think that’s the word he uses!).
Does anyone remember Highlights magazine, where you had to find hidden objects — like a hammer tucked inside a tree?
That’s exactly what this feels like!
Can you spot the word brensocatib hidden in the diagram?
Many of us have been following the development of brensocatib for years, from the Phase 2 WILLOW trial to the Phase 3 ASPEN trial.
Although the results were shared publicly last year and discussed extensively at the Bronchiectasis World Conference in Dundee, Scotland, the findings have now been formally published in The New England Journal of Medicine, one of the most prestigious medical journals in the world.
I knew the article was coming, as I’ve heard Dr. Chuck Daley reference it multiple times. How exciting — for him, for the bronchiectasis community, and for all of us living with the heavy burden of this disease and desperately needing relief.
So, as I always say, let’s continue to stay the course: keep our weight in a healthy zone, eat nutrient-dense foods, do our airway clearance, exercise, control GERD, and just as importantly, try to have faith and relax — knowing that help is on the way!
Happy weekend,
Linda Esposito
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n-1721
20% fewer exacerbations
52-week decline in FEV1 reduced by 50%
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1 Reactionhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11770772/
WILLOW-trial , n=256
the annualised exacerbation rate was lower for patients treated with brensocatib
regardless of blood eosinophil counts
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1 ReactionOther than pneumonia and severe infection?!!
If we are looking at adverse reactions, we need to compare them to the placebo. The placebo column is all the way to the right in the chart. Also, the Aspen phase 3 study had over 1700 participants. The Willow study had I think 250 Ish.
My husband has been on it since the beginning. We are convinced he got the placebo because there wasn’t much change. As soon as they started giving him the real medication, it has made a huge difference. He has no cough and gets hardly anything up. It’s quite remarkable.
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4 ReactionsFantastic to hear, big fish!
I am so hopeful! It would be a total godsend if Brensocatib could decrease my daily sputum by one half and decrease my cough episodes outside my airway clearance times.
Research for our condition is long overdue and I am grateful for companies now willing to explore treatments for our somewhat unique lung disease. Somehow the concept of neutrophils overdoing their jobs in our lungs just feels like a perfect place to start!
Pulmonologists in my opinion will be grateful too, having something more to help us.
I live in the Metropolitan Detroit area and wanted to participate in the study but the nearest center was Chicago and they felt it was too far for me to troop to for the necessary follow ups. I love all the success stories!
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1 ReactionGreat news for you & your husband. Thanks for letting us know.
OMG this sounds sooooo promising! Hopefully it gets approved by the FDA soon!! I believe that I’ve heard or read that it’s possible to be approved sometime in August or September is this true, does anyone know? I also think that it would take some time to manufacture it to have a suitable amount for Dr.s to prescribe. I know I DO NOT know the steps after FDA approval can anyone enlighten me on them? Thank-you, in the meantime we all must stay the course and fight on!!!!!
I was at the Lung Institute at DMC for years and I had Dr Kissner, who is world famous. Have you gotten care there?
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