Adrenaline spikes: Med detective needed, award given

This happens to me as well.
I wake up like clockwork every morning at 7am - feeling like I am full of adrenaline. It's a horrible feeling.
Then a get waves of adrenaline like surges throughout the day. I can only work for 3 hours - most of that time I feel agitated / restless. And it peaks so much that I cannot work and have to go rest. My condition is ruining my life. It's really bad. I haven't been able to relax / take a nap in 3 months. I don't know what is happening. Getting more blood work done soon. Don't have much strength left.

I’m going to give this a go, all of you have similar symptoms, have any of you been on any psychiatric drugs and come off them cold turkey, or any medications that you have abruptly stopped, the reason I’m asking because you can go through awful withdraw. Some of the symptoms your describing sounds like withdrawl, I know this is a long shot but can be a possibility.

@sierrawoods have you found any answers? It sounds similar to what I have been dealing with. Morning rushes between 4-7. Chills and nausea for almost two years.

I experienced symptoms similar to SierraWoods condition. I'm 54 y.o. post menopausal woman with previously excellent health (runner, weight lifter, paddleboarder). It started in Sept/Oct 2022. Mine also included Frozen Shoulder, my guts felt inflamed, my eyes and skin felt burning, light and noise sensitivity, I didn't feel sensations of sleepyiness or hunger just felt "bad" instead, ringing ears, Reynauds phenomenon, crushing insomnia, felt internal tremors, as well as the adrenaline spikes and fluctuating BP and HR, etc. Very low night time BP 89/48. Urinating a lot at night. Sitting down during day my HR 52, immediately standing HR 102. Sit back down and it's 58 again in seconds. No one could figure it out. I saw endocrinologist, 2 PCPs, rheumatologist, cardiologist, gynecologist, dermatologist, ophthalmologist, etc for the various symptoms. All my tests and labs came back relatively normal. Slightly higher morning cortisol, slightly higher norepinephrine/epinephrine. Small inconsequential nodule on thyroid. My heart echo was clean, heart rhythm recorder was clean, wore blood glucose monitor for weeks and it was clean, rheumatology I was negative for autoimmune, etc. Tentative diagnosis was Postural Orthostatic Tachycardia Syndrome (POTS).
My own personal theories of things that may have contributed to or caused to my "illness":
-I started feeling generally bad a few months after getting the Pfizer Covid vaccine Spring 2021. Not full blown symptoms as described as above, just off and a general feeling of unwellness.
-This also started right when I finished going through menopause. Hormone related?
-I had my genetics tested. I have the COMT and MTHFR gene variants. This may mean I do not methylate well, Medications also build up in my system as I am a slow metabolizer. Explanation: https://www.drlamcoaching.com/blog/complete-guide-to-the-comt-mutation/
-I was on oral conjugated estrogen and progesterone. Did great at first, then increasingly bad over 3 months (see COMT gene link above). I was a poor methylater. Stopped cold turkey after waking to a HR of 155 at 3 a.m. Thought I was having a heart attack. Went to ER. All tests normal. One month later, all of the full blown symptoms described above started. Endocrinologist suggested I may have gone through Endocrine Withdrawal Syndrome after stopping the estrogen and progesterone which he said feels like you are withdrawing from opioids. I googled it and the symptoms were similar (I was not on opioids).
-I was on a diet Spring of 2022. I consumed a TON of vitamin and minerals through nutrition bars, high protein meal replacement shakes and pre-packaged foods for 6 months. May have caused a buildup in my system?
-I was on a 5 day course of broad spectrum 875/125 Augmenting antibiotics early August 2022. Stopped after tachycardia attack. They may have wiped out my microbiome and my gut may have repopulated with "bad" bugs?
-I got a Tdap booster vaccine late August 2022. All hell seemed to break loose a month after that, but could have been coincidence.
Three weeks ago, I finally started to feel normal with no symptoms. My frozen shoulder also disappeared around this time. (That is allegedly connected to hormones). I finally saw my first neurologist four days ago. Very highly regarded doctor. He said I have orthostatic intolerance (POTS) but did not do a tilt table test because I am getting better and the test would probably be inconclusive. He also said based on all of the information I gave him that this all started with the Covid vaccine and the Tdap booster may have aggravated it. He said based on the data they are getting from Northwestern University, right now the #3 cause of neurological injury appears to be Covid or Covid vaccine related (he is not against vaccines).
I don't know how I feel about that. I ran it past a neurologist friend and his reply was that the other neurologist has no idea what actually caused my symptoms. I also realize SierraWoods problem predates Covid and the Covid vaccine. But that is not to say that this could be a viral thing in general. No wonder nobody can figure any of this out.
In my gut, I think my "illness" is related to hormones and/or an enzyme that I usually have that I am no longer making, but not sure why. Probably due to declining estrogen and hormones. It's also possible I had more than one thing and they all dog-piled and it was more than my system could handle.
Anyways, after eleven months, I have had no symptoms for two weeks finally! I have been making very slow progress since January and finally am getting to days with no symptoms!
Things I did:
-I never took any of the medication that any doctor prescribed to me. I thought the side effects of medication would make things worse since I know myself and know I don't process medications well. They mainly wanted me to take beta blockers and fluid boosters to improve blood volume to get my BP higher.
-I wasn't sure if I was getting enough iodine because I was very low/no salt and it was sea salt. I had very low blood pressure, so I started drinking water with iodized salt in it. This is basic Postural Orthostatic Tachycardia Syndrome protocol, for the most part. It helped to increase my blood volume and get my blood pressure up.
-Rest
-Stopped all caffeine and alcohol
-Stopped taking all supplements except vitamin C (and I was not on any medications except vaginal estrogen cream, kept that). Vitamin C is a cofactor in catecholamine synthesis, converting dopamine to norepinephrine, and synthesizing vasopressin, etc.
-Stopped eating dairy which is theoretically inflammatory
-Started eating a lot of high nutrient dense foods. 1lb spinach, 2 lbs cherries, 2.5 lbs fresh clams in shell, sardines, bananas, etc.
-Forced myself to start exercising since January with walking (my HR was 130 with a simple slow walk). I made progress over months. I was out walking in the park with all the old people in walkers not going much faster than them. But slowly I improved and was able to walk for longer. The big change for me came when I started weight training while seated.
Hopefully, I will continue to improve and stay symptom free. We shall see, but I am hopeful to have even got this far!

I’m at a loss as to how to respond to this discussion. It originated 7 years ago, has 22 pages now total and is still going. Many of the members responding are familiar names. I may have contributed something myself over the past 7 years / 22 pages. Unfortunately there are still more questions than answers about this condition. Please everybody keep sharing your experiences. We are here to support and encourage each other. Nobody should be feeling alone.