Bleeding with Levalbuterol nebulizing

Posted by paxmundi @paxmundi, Mar 28 10:48am

Dear Friends,

I nebulized on Wednesday for first time with Levalbuterol. .63 and 3% saline. It went well. That night after the Levalbuterol during my second session I started to spit up small amounts of frank red blood and it continued intermittently until 2 am. Next morning I spat up some brownish blood and a little blood-tinged mucus. Then no more. Altogether it was about a t son and a half. Very scary but I decided not to go to the emergency room and I’m glad I didn’t. I didn’t nebulize yesterday nor do I plan to do so for a while. Has anyone experienced something like this with nebulizing? I am going to continue all my other airway clearance practices: Aerobika, autonomic drainage, stack breathing, ACB, but this scared me sib e I have a history of massive hemoptysis. Thanks in advance for any insights.

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@irenea8

Apparently Levobuterol can cause bleeding as a side effect. Have you tried nebulizing with only saline 3%? And you are just supposed to breath normally while you nebulize. Maybe let things settle down and try again with just the saline sometime?

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Irene, where did you read this? I brought it up in a different forum and someone contested that this was the case. My experience is that it did, but it would be great to find a study that found that. All I saw was that Mayo Clinic lists bleeding as a rarer side effect: nose bleeds, heavier menstruation, blood in urine. Thank you for your good suggestion. I really need a good while for this to settle down but that is exactly what I hope to try.

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This is from AI:

While levalbuterol nebulization is generally safe, it's rare but possible for it to cause lung bleeding (epistaxis) or other respiratory issues as a side effect.
Here's a more detailed explanation:
Side Effects:
Levalbuterol, like other medications, can cause side effects, and while lung bleeding is not a common side effect, it's important to be aware of the possibility.
Other Respiratory Issues:
Other respiratory side effects that have been reported include asthma exacerbation, wheezing, and coughing.
Serious Reactions:
If you experience severe breathing problems, worsening asthma, or any other concerning symptoms after using levalbuterol, seek immediate medical attention.
Allergic Reactions:
Get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

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@irenea8

This is from AI:

While levalbuterol nebulization is generally safe, it's rare but possible for it to cause lung bleeding (epistaxis) or other respiratory issues as a side effect.
Here's a more detailed explanation:
Side Effects:
Levalbuterol, like other medications, can cause side effects, and while lung bleeding is not a common side effect, it's important to be aware of the possibility.
Other Respiratory Issues:
Other respiratory side effects that have been reported include asthma exacerbation, wheezing, and coughing.
Serious Reactions:
If you experience severe breathing problems, worsening asthma, or any other concerning symptoms after using levalbuterol, seek immediate medical attention.
Allergic Reactions:
Get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.

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Thank you, Irene. Do they happen to cite any evidence for this?

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When side effects of Drugs are listed do they ever site what the evidence is? Drugs.com also lists bleeding as a less common side effect. The AI generated information I sited does not list "evidence". It is rare but can happen if you are very prone to it I would imagine.

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I agree with you 100%. I doubt the Mayo Clinic would post something if there wasn't evidence behind it. But someone contested that since there's no citation. The person was trying to convince me that the Levalbuterol didn't trigger my bleeding, which occurred immediately after nebulizing deeply with it. I disagree!

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Sometimes bleeding can be due to an infection

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@paxmundi

I agree with you 100%. I doubt the Mayo Clinic would post something if there wasn't evidence behind it. But someone contested that since there's no citation. The person was trying to convince me that the Levalbuterol didn't trigger my bleeding, which occurred immediately after nebulizing deeply with it. I disagree!

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@paxmundi If I recall correctly, your lungs are prone to hemoptysis and you must be extra cautious...that said, it doesn't surprise me that you would be someone who had a rare side effect of bleeding from levalbuterol.
If you read a summary of all the pre-release studies of Xopenex/levalbuterol, this was not a known side effect, but remember that test populations are carefully pre-screened. I doubt if anyone with a history of hemoptysis, especially severe episodes, would have been accepted.

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@paxmundi i’m sitting here listening to Dr. James Chalmers Talk on updates from European forum on respiratory tract infections from February and around the 1 hour and 30 minute mark, he discusses hemoptysis. You might like to listen to it as he suggests treatments.

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Thanks so much, Scoop. I will give this a listen. I listened to NTM Talk’s episode on Hemoptysis and a YouTube lecture by Dr. Mark Metarsky that focused on it as well. I’m glad I didn’t go to emergency room and get hooked up to an antibiotic IV without culture or susceptibility testing, and then on antibiotics. The bleeding luckily stopped pretty quickly with spotting very light dark blood on the subsequent two days. I know I have very delicate lungs and I am praying that over time airway clearance practices continue to make me stronger, and less susceptible to irritation and more importantly, repeated infections and degeneration of lung function. Eager to have a doctor who actually knows something about all this.

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@sueinmn

@paxmundi If I recall correctly, your lungs are prone to hemoptysis and you must be extra cautious...that said, it doesn't surprise me that you would be someone who had a rare side effect of bleeding from levalbuterol.
If you read a summary of all the pre-release studies of Xopenex/levalbuterol, this was not a known side effect, but remember that test populations are carefully pre-screened. I doubt if anyone with a history of hemoptysis, especially severe episodes, would have been accepted.

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Great input, Sue.

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