Strontium citrate, fractures and lack of research

@karenjaninaz Can you share which specific tablets/capsules you have found that incorporate all of the elements recommended in the studies? Thanks!

Just look at the studies; they have a list. Right now I am on Prolia as a preventive because I have osteopenia. I started taking strontium citrate 340mgm with it but then thought they might not mix well. I don’t want another Prolia because I had 2, and now the dreaded Reclast. I am still on lowering doses of prednisone so that’s considered a high risk. I’m also eating prunes for what that’s worth. I stopped Algae Cal because I can never tolerate any calcium supplements in it; I use lactose free yogurt smoothies and cheeses.
My primary doc, a geriatrician, OK’d the strontium citrate. I’ve yet to run it past my endocrinologist.
Since strontium is ubiquitous in the soil drug companies make no profit on drug development. There are studies on animals though by other countries.

Here is a posting of research and studies on strontium research which might be helpful to you in your deep dive into strontium research. Notice the bone biopsies and the 2020 review of strontium research etc.. https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/dd823b-strontium-a-compilation-of-research-and-information/
Also, notice the TBS research and newer Rems information.

In the research which you cited, but did not discuss, about the interaction amongst calcium, strontium, and citrate ions, notice that the addition of strontium was found to increase calcium bioaccessibility from calcium citrate suspensions at different temperatures. ( a partial quote from the research)
https://www.sciencedirect.com/science/article/pii/S0167732224000151
I see that you may have misread part of the 2021 research when you say that oral Strontium Ranelate does not affect bone formation. Notice that your provided quote is referring to bone defects not osteoporosis and is in the section discussing local use of strontium for bone defects not osteoporosis. This is not a quote about osteoporosis but about the need for strontium laced materials to be applied directly to the site of the bone defect.
Titled "Local Administration of Strontium Ions". The quoted portion which you provide contrasts the use of strontium used directly at the site of the defect as opposed to oral administration and then points out that strontium is needed directly at the site of the defect rather than orally. It is not negating the use of oral strontium for conditions such as osteoporosis. see acutal osteoporosis quotes from the article below
To reiterate
You say:
"Later in the article they add: "Orally administered strontium ranelate does not significantly affect bone formation in vivo because it does not reach a sufficient concentration near this tissue, assuming a standard drug supply and a normal calcium-rich diet.""
This is a statement about specific bone defects not osteoporosis. No one doubts that specific areas of bone damage need a more concentrated application of strontium. Multiple research upholds this as does current use.
Strontium laced products applied directly to the area of concern are being used in multiple ways for bone defects, jaw necrosis, cranial burr holes. see my first linking of a compilation of strontium research where there is a list of such applications
When osteoporosis is discussed in your 2021 linked research, rather than bone defects, the article says: "Strontium can also be incorporated into bone cells, which increases their density and reduces the risk of developing osteopenia and osteoporosis. "
Then this statement about osteoporosis, strontium and fractures is found:
"The SOTI (Spinal Osteoporosis Therapeutic Intervention) study found a reduction in the incidence of spine fractures in postmenopausal women after just one year of treatment. This decrease, compared to the placebo control group, amounted to 49%. A three-year double-blind study showed a 41% reduction in the incidence of new spine fractures, compared with a placebo group. TROPOS (treatment of peripheral osteoporosis) studies have shown the effective anti-fracture effect of ranelate on non-vertebral fractures within the first three years of use. These fractures were reduced by 16% [37,38,39]."
Plus, a long discussion of how strontium works with osteoblasts and osteoclasts to form bone.

Strontium citrate is easily obtained as a supplement in itself without the price tag of the AlgaeCal products. AOR and Vitacost are just two providers.

Part of a deep dive into strontium might be to research the newer bone tests such as REMS and Dexa with TBS. Both of these bone scans show that strontium users have good bone density and good bone quality. The research of Dexa with TBS shows that strontium users place within the top three of bone quality results. Page 7 of the research, https://www.panoramaortho.com/wp-content/uploads/2019/03/TBS-Review-JBMR-2014.pdf
see further research in the first provided posting of strontium research at the top

The discussion of strontium ranelate, its differences and its complicated history in the European medical community makes for a long and involved posting. It may be found in my first linked offering above.
Probably the quickest answer is that strontium ranelate is not available in the USA. Strontium citrate is available and strontium citrate has never been banned or limited in its use. I do think that further testing would be helpful, but the current testing and research has not found strontium citrate to be associated with any cardio vascular problems.

There is a tendency to "poo-Poo" strontium use in terms of osteoporosis results. This probably has to do with a back lash against the Naural vs Medical discussion. My use of strontium for my once osteoporosis now "normal" bones is based entirely on research and on my doctor's recommendations. There are not many osteoporosis treatments which have years of research, bone biopsies, plus good results from DEXA, REMS, and TBS and an almost non existent chance of side effects. Strontium is hard to believe, but a read of the actual research and studies at least says that this is a supplement which needs more study.
Thank you for the discussion.

Just look at the studies; they have a list. Right now I am on Prolia as a preventive because I have osteopenia. I started taking strontium citrate 340mgm with it but then thought they might not mix well. I don’t want another Prolia because I had 2, and now the dreaded Reclast. I am still on lowering doses of prednisone so that’s considered a high risk. I’m also eating prunes for what that’s worth. I stopped Algae Cal because I can never tolerate any calcium supplements in it; I use lactose free yogurt smoothies and cheeses.
My primary doc, a geriatrician, OK’d the strontium citrate. I’ve yet to run it past my endocrinologist.
Since strontium is ubiquitous in the soil drug companies make no profit on drug development. There are studies on animals though by other countries.

Thank you for your info...I have a question, when you say you cannot tolerate calcium supplements.... What happens?

Did your endocrinologist ok taking Reclast and Strontium Citrate?

Thank you for this thorough post. My endocrinologist went as far as to say that she would no longer treat me if I were to use AlgaeCal, citing an FTC lawsuit (which mainly pertained to the marketing claims). You can do a simple search for case No. 12-12382-AA against "Garden of Life"

I am, however, interested in trying strontium citrate. I see the amount in AgaeCal is 680 mg. I am curious as to the dose you are currently taking, as this seems high?

@equalshot Is your endocrinologist ok with Strontium Citrate but just not Algaecal because of the lawsuit from 2012?