Evenity

Do you have any cardiac issues, susanew?

Were the shoulder aches attributed to the Evenity?

Hi, windyshores, and sorry so long in thanking you for your reply to my question about Evenity. I saw my cardiologist this week; he googled the drug and said he didn't think it would be risky for me, but as I am terrified of the possibility of stroke, he is going to do a carotid study. I was very happy that Evenity might be an option for me... until the next day when I went to see my new endocrinologist. She said she had had two patient with no cardiac history who had heart attacks after being put on Evenity. Jeez Louise. I now don't know what to think. The endo is leaving the decision -- Prolia or Evenity -- up to me, but if I go with Evenity, she wants a statement first from my cardio that he okayed it. Obviously, she has concerns.

My cardiologist's attitude was that I am at such high risk for fracture that I should use anything possible, and I am worried about Prolia after reading so many Mayo Connect postings re: increased fracture risk if Prolia is stopped. I have spent nearly two years on Tymlos with little improvement, and have paid for that not only with big bucks but with nightly nausea and headaches. My fear is that I will have similar side effects with Prolia and have to quit. Do you happen to know if Prolia can be followed with Evenity? The new endo said it is most often followed with Reclast.

Thanks again for any help you can give!

Hi, windyshores, and sorry so long in thanking you for your reply to my question about Evenity. I saw my cardiologist this week; he googled the drug and said he didn't think it would be risky for me, but as I am terrified of the possibility of stroke, he is going to do a carotid study. I was very happy that Evenity might be an option for me... until the next day when I went to see my new endocrinologist. She said she had had two patient with no cardiac history who had heart attacks after being put on Evenity. Jeez Louise. I now don't know what to think. The endo is leaving the decision -- Prolia or Evenity -- up to me, but if I go with Evenity, she wants a statement first from my cardio that he okayed it. Obviously, she has concerns.

My cardiologist's attitude was that I am at such high risk for fracture that I should use anything possible, and I am worried about Prolia after reading so many Mayo Connect postings re: increased fracture risk if Prolia is stopped. I have spent nearly two years on Tymlos with little improvement, and have paid for that not only with big bucks but with nightly nausea and headaches. My fear is that I will have similar side effects with Prolia and have to quit. Do you happen to know if Prolia can be followed with Evenity? The new endo said it is most often followed with Reclast.

Thanks again for any help you can give!

@bayhorse you can also look up the FRAME and ARCH studies. There was no difference in cardiovascular issues (including heart attack and stroke) between Evenity and placebo, but a small but statistically significant difference with alendronate. Articles propose that the latter result may be because alendronate is slightly protective.

Your endocrinologist's opinion seems unusual since I have talked to two endos and two cardiologists about Evenity with full go ahead and they are all in a top hospital system.

I can only repeat what my doctors tell me. They do not use Prolia unless absolutely necessary, due to the rebound when stopped. They do use Evenity, Forteo, Tymlos and bisphosphonates.

As for my unusual reactions, yes I have a systemic lupus diagnosis and very high antibodies for scleroderma. I react to foods, meds and scents. That said, doing the shots in my thighs seemed to help. Evenity has polysorbate 20 (not polyethylene glycol as I posted elsewhere, but chemically related). I would do Evenity again. My friends have done amazingly on it.

Hi, again, windyshores, and again, thank you for the info. Would you mind saying again what your cardiac issue is? I know you mentioned it in an earlier post, but can't locate it.