Strontium citrate, fractures and lack of research

There is an Inspire poster that is fairly well known, PhoneyBoney. She was also fracturing on bisphosphonates etc.; I believe that she took various drugs.
She self reports that after taking strontium citrate that she stopped fracturing.
The links which I sent you has a 2020 compilation of strontium research; in that compilation the scientists say that one reason strontium has such a high success of preventing fractures is because it seems to make something called "sacrificial bonds" which allow the bone to sustain more injury.
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/dd823b-strontium-a-compilation-of-research-and-information/
I don't know if this sacrificial bond is what stopped PhoneBoney's bisphosphonate fracturing, but it is possible.
Strontium user stories:
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/strontium-users-stories-2-alternative-to-pharma-meds/

Thanks for the additional info. I fractured 13 months ago and have not fractured since so I hope I am on the right path now. I stopped Fosamax 11 months ago, was off all meds for 3 months, then did 4 months of Tymlos followed by two months off and now on teriparatide.

Knowing what I know now, I would never have taken Fosamax for as long as I did.

That is very interesting info regarding the "sacrificial bonds". Looking forward to diving into the info after work today.

I was on the Inspire forum shortly after my fracture was diagnosed but dropped it when I was told (in very bold and insistent terms) that Tymlos would give me cancer.

Yes, there were some studies with rats that showed a risk of bone cancer. I have not seen any research to back this up with humans. But the warning was on the Tymlos site, at least at one time.
https://tymlos.com/
Research:
" the initial phase 3 trials of the bone anabolic drug teriparatide were stopped because of a preclinical finding of osteosarcoma in rats treated with high doses of teriparatide for near lifetime. Even so, teriparatide was observed to reduce fracture risk in postmenopausal women with osteoporosis and showed efficacy and tolerability in the phase 3 program and in subsequent studies with a positive benefit to risk profile. Based on the phase 3 results, additional preclinical findings, and with risk mitigations, the agent was approved for use. Subsequent studies including in real‐world settings have not identified an increased risk of osteosarcoma in humans, and the label has been updated and adjusted, including removal of the boxed warning and a revision of the 2‐year lifetime limitation. Thus, observational studies with large sample sizes using real‐world data can be an important and efficient strategy for generating evidence in support of regulatory decision making and significant label updates."
https://pmc.ncbi.nlm.nih.gov/articles/PMC9465003/

I am interested in knowing how hard Strontium is on kidneys. I try to get all my calcium from milk, yogurt, cheese, leafy greens etc.

But @mcchesney the study that was cited above measured increase in DEXA, which may be a false increase. I would like to see a study on improvement in REMS and TBS if those are now available to more people.

The suggested therapeutic dose for strontium citrate is 680mg, the dose in Strontium Boost.

I am not at all critical of strontium use and tried it 18 years ago for a short time,. I would love good news given my sensitivities to most med options (which I am doing anyway in an adjusted fashion). But I need more than a study showing increase in DEXA on strontium since we know it is denser than calcium and throws the scan results off, I cannot afford to try a year and compare results done the second time with the first- bones can't afford that risk! In any case it may work too slowly for those of us with severe osteoporosis.

Hi
Thanks don't think I will bother with it

I followed the Duquesne University study of strontium citrate with other micro nutrients. I only use 340 mg and reversed my osteoporosis to osteopenia in a year. The study was very involved in study of the bone cells.

Here is a posting of research and studies on strontium research which might be helpful to you in your deep dive into strontium research. Notice the bone biopsies and the 2020 review of strontium research etc.. https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/dd823b-strontium-a-compilation-of-research-and-information/
Also, notice the TBS research and newer Rems information.

In the research which you cited, but did not discuss, about the interaction amongst calcium, strontium, and citrate ions, notice that the addition of strontium was found to increase calcium bioaccessibility from calcium citrate suspensions at different temperatures. ( a partial quote from the research)
https://www.sciencedirect.com/science/article/pii/S0167732224000151
I see that you may have misread part of the 2021 research when you say that oral Strontium Ranelate does not affect bone formation. Notice that your provided quote is referring to bone defects not osteoporosis and is in the section discussing local use of strontium for bone defects not osteoporosis. This is not a quote about osteoporosis but about the need for strontium laced materials to be applied directly to the site of the bone defect.
Titled "Local Administration of Strontium Ions". The quoted portion which you provide contrasts the use of strontium used directly at the site of the defect as opposed to oral administration and then points out that strontium is needed directly at the site of the defect rather than orally. It is not negating the use of oral strontium for conditions such as osteoporosis. see acutal osteoporosis quotes from the article below
To reiterate
You say:
"Later in the article they add: "Orally administered strontium ranelate does not significantly affect bone formation in vivo because it does not reach a sufficient concentration near this tissue, assuming a standard drug supply and a normal calcium-rich diet.""
This is a statement about specific bone defects not osteoporosis. No one doubts that specific areas of bone damage need a more concentrated application of strontium. Multiple research upholds this as does current use.
Strontium laced products applied directly to the area of concern are being used in multiple ways for bone defects, jaw necrosis, cranial burr holes. see my first linking of a compilation of strontium research where there is a list of such applications
When osteoporosis is discussed in your 2021 linked research, rather than bone defects, the article says: "Strontium can also be incorporated into bone cells, which increases their density and reduces the risk of developing osteopenia and osteoporosis. "
Then this statement about osteoporosis, strontium and fractures is found:
"The SOTI (Spinal Osteoporosis Therapeutic Intervention) study found a reduction in the incidence of spine fractures in postmenopausal women after just one year of treatment. This decrease, compared to the placebo control group, amounted to 49%. A three-year double-blind study showed a 41% reduction in the incidence of new spine fractures, compared with a placebo group. TROPOS (treatment of peripheral osteoporosis) studies have shown the effective anti-fracture effect of ranelate on non-vertebral fractures within the first three years of use. These fractures were reduced by 16% [37,38,39]."
Plus, a long discussion of how strontium works with osteoblasts and osteoclasts to form bone.

Strontium citrate is easily obtained as a supplement in itself without the price tag of the AlgaeCal products. AOR and Vitacost are just two providers.

Part of a deep dive into strontium might be to research the newer bone tests such as REMS and Dexa with TBS. Both of these bone scans show that strontium users have good bone density and good bone quality. The research of Dexa with TBS shows that strontium users place within the top three of bone quality results. Page 7 of the research, https://www.panoramaortho.com/wp-content/uploads/2019/03/TBS-Review-JBMR-2014.pdf
see further research in the first provided posting of strontium research at the top

The discussion of strontium ranelate, its differences and its complicated history in the European medical community makes for a long and involved posting. It may be found in my first linked offering above.
Probably the quickest answer is that strontium ranelate is not available in the USA. Strontium citrate is available and strontium citrate has never been banned or limited in its use. I do think that further testing would be helpful, but the current testing and research has not found strontium citrate to be associated with any cardio vascular problems.

There is a tendency to "poo-Poo" strontium use in terms of osteoporosis results. This probably has to do with a back lash against the Naural vs Medical discussion. My use of strontium for my once osteoporosis now "normal" bones is based entirely on research and on my doctor's recommendations. There are not many osteoporosis treatments which have years of research, bone biopsies, plus good results from DEXA, REMS, and TBS and an almost non existent chance of side effects. Strontium is hard to believe, but a read of the actual research and studies at least says that this is a supplement which needs more study.
Thank you for the discussion.

I believe that you are referring to this product:
Garden of Life Organics Plant Calcium Supplement Made from Whole Foods with Magnesium, Vitamin D as D3, and Vitamin K as MK7, Gluten-Free
It contains 6mg of strontium which is provided by the algae. This is a vitamin dose level.

Most of the strontium discussion which we are having centers around a therapeutic dose of strontium, research based level to impact osteoporosis; this is usually 680mg daily sometimes transitioning to a maintenance dose of 340mg.

Congratulations on moving to osteopenia from osteoporosis! I am considering taking strontium citrate. Do you mind if I ask what your bone density score was before and after? And did you experience any side effects from it? Also what was the brand you took?