Strontium citrate, fractures and lack of research

Posted by pami @pami, Apr 15, 2024

I am looking to see if there are any studies done that show a reduced chance of fracture from using Strontium citrate (Algaecal) as opposed to calcium. Everything I have read only mentions increase of density using it. Does anyone have doctor input or a study showing an decrease in bone fractures?

***Director's Note:***
There’s not enough clinical research to know if strontium citrate effectively prevents or treats osteoporosis. Mayo Clinic does not recomend its use. Clinically researched osteoporosis medications have demonstrated fracture prevention benefit with less risk.  

The FDA doesn’t regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain.

If you wish to take a strontium supplement, it is advised to discuss with your doctor. 

All information shared by members on the Mayo Clinic Connect is for informational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your health. Never disregard professional medical advice or delay in seeking it because of something you have read on the community.

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Profile picture for awfultruth @awfultruth

@nene78 I'm about as far from an expert as possible in chemistry but a simple lookup will tell you that strontium is a metal. You may want to get it from algae which has absorbed it rather than from a chunk of rock but it is still a metal.
From Wikipedia: " An alkaline earth metal ... Strontium is a divalent silvery metal with a pale yellow tint whose properties are mostly intermediate between and similar to those of its group neighbors calcium and barium.[10] It is softer than calcium and harder than barium. "

To me the important points are:
How well does it work to prevent fractures?
If it increases bone density is it building stronger and functional bone?
What are the possible side effects?
Are the problems with strontium ranelate likely to occur with strontium citrate?
Are the studies of strontium ranelate directly relatable to strontium citrate?

I admit I haven't investigated strontium enough and I do intend to investigate more.
I do know that the logic that strontium citrate is natural and meds are unnatural is not a sound basis for thinking it's ok to take. Large doses of trace minerals can be quite dangerous no matter how "natural" they are. The 640mg dose of strontium citrate is way way greater than the 1-5mg we would likely get per day in food.
Still, it would be great if strontium citrate was really an effective agent for bone thinning.

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You may be interested in reading the “deep dive” med publications cited above. Looks promising

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Profile picture for nene78 @nene78

You may be interested in reading the “deep dive” med publications cited above. Looks promising

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@nene78 Hi there. I read the osteoporosis section just now and it is quite positive. And I do intend to keep researching strontium.

Your intake of 12mg is quite low and maybe not a level that would trigger alarms for the different potential problems with strontium?
Here's one of my favorite pieces on strontium from Dr Alan Gaby a nutritional oriented doctor who I greatly respect.
https://townsendletter.com/editorial-05-18-gaby-high-dose-strontium/

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Profile picture for nene78 @nene78

I would like to thank you for the deep dive article. It gave me some insight as to whether I should continue to take the strontium from “organic algae” or not. Interestingly it actually exists in ocean and river water, hence the absorption into the algae. The dose is low-4 mg/dose/day do I will continue and if you come across any further info please post it.

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I agree if you are taking just the AlgaeCal with trace elemental minerals incorporated. This is like consuming naturally occurring strontium in our food.

However I remain concerned about the "Strontium Boost" supplement, which is 680 mg of Strontium Citrate; according to their website is sourced from elemental strontium from soil combined with citrate.

The daily dose is equivalent to twice the TOTAL amount of strontium that occurs naturally in our bones.

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Profile picture for Sue, Volunteer Mentor @sueinmn

I agree if you are taking just the AlgaeCal with trace elemental minerals incorporated. This is like consuming naturally occurring strontium in our food.

However I remain concerned about the "Strontium Boost" supplement, which is 680 mg of Strontium Citrate; according to their website is sourced from elemental strontium from soil combined with citrate.

The daily dose is equivalent to twice the TOTAL amount of strontium that occurs naturally in our bones.

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@sueinmn from the article I believe the therapeutic dose of 680mg might be up to 200 times what we get from food. Side effects, especially cardiovascular, are a concern. I was however interested in the info in the article on possible benefits of low dose strontium (excerpt below). I still wonder if the 4mg or so that is typical in various supplements has any effect. We need more research!

"Researchers should investigate the possibility that the beneficial effects of high-dose strontium could be duplicated at least in part by much lower “nutritional” doses, such as 2-6 mg per day. The improvement in bone quality that results from the incorporation of strontium into hydroxyapatite crystals likely occurs with small doses of strontium, since strontium is present in the hydroxyapatite crystals of people who do not take strontium supplements. The possibility that low-dose strontium is beneficial is supported by the results of one study, in which the reduction in fracture incidence was nonsignificantly greater with 170 mg per day of strontium than with 340 or 680 mg per day. Whether doses less than 170 mg per day would influence bone mineral density or fracture risk has not been investigated."

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Profile picture for awfultruth @awfultruth

@nene78 Hi there. I read the osteoporosis section just now and it is quite positive. And I do intend to keep researching strontium.

Your intake of 12mg is quite low and maybe not a level that would trigger alarms for the different potential problems with strontium?
Here's one of my favorite pieces on strontium from Dr Alan Gaby a nutritional oriented doctor who I greatly respect.
https://townsendletter.com/editorial-05-18-gaby-high-dose-strontium/

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Thank you for the informational article. I wish I could find info on strontium occurring in water, “organic algae” so I would know if I’m harming myself! I did have a suprising effect taking 5 mg/day-5% bone increase in dexa. My endocrinologist was really suprised. I would like to find an ongoing study to participate in. If you or anyone heard of one I’d appreciate hearing of it. Regards, Renee

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Profile picture for nene78 @nene78

Thank you for the informational article. I wish I could find info on strontium occurring in water, “organic algae” so I would know if I’m harming myself! I did have a suprising effect taking 5 mg/day-5% bone increase in dexa. My endocrinologist was really suprised. I would like to find an ongoing study to participate in. If you or anyone heard of one I’d appreciate hearing of it. Regards, Renee

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@nene78 the problem is that you cannot know for sure that that increase is real. I have read the DEXA should be adjusted by 10% for strontium but that may have been for the 680mg.

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Thank you for your reply. I actually called the vitamin company today and asked for the “studies” done on the strontium they are using in their vitamin. We will see if they reply to me! And you are right-no way of knowing!

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Profile picture for nene78 @nene78

Thank you for your reply. I actually called the vitamin company today and asked for the “studies” done on the strontium they are using in their vitamin. We will see if they reply to me! And you are right-no way of knowing!

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Here is one of the Algaecal studies:
https://pubmed.ncbi.nlm.nih.gov/21492428/
Any study on strontium will be a study on Algaecal strontium.

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Profile picture for mcchesney @kathleen1314

Here is one of the Algaecal studies:
https://pubmed.ncbi.nlm.nih.gov/21492428/
Any study on strontium will be a study on Algaecal strontium.

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What are Algaecal 1 and 2? Are these Algaecal (no strontium) , Algaecal Plus (trace strontium) or Bone Builder pack with Strontium Boost (680mg strontium)?

I am certainly interested in this study but find the website fundamentally flawed by mentioning a promised increase in DEXA scores without explaining that the improvement may be illusory.

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Profile picture for mcchesney @kathleen1314

Here is one of the Algaecal studies:
https://pubmed.ncbi.nlm.nih.gov/21492428/
Any study on strontium will be a study on Algaecal strontium.

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Thank you for your reply and information. My vitamin is called MyKind and is a plant based Cal, K2 Mag and Strontium vitamin. Not sure how it compares to Algaecal.

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