Nausea taking 2.4 mg of wegovy. No issues before

Don’t give up. Oh on the nausea my daughter said to try the injection at bedtime and hello no nausea. I’m sorry it’s going slow but try to picture you later. I wish you the best

I start my level 1 (WEGOVY) next Monday. So far very little affect on appetite or snacking. Some minor constipation like symptoms but nothing really than an annoyance.

My PCP stated to start taking Miralax to counter the constipation especially since was starting the 1 next Monday.

Is the consensus that the .25, .50 don't do much? I was told they have to start with low doses to see what side affects you will get thus cannot start with a higher dose. What did you see at the 1 level?

What has been the experience of those taking WEGOVY at the .25, .50, and the 1?

No huge side effects until the last stage of 2.4 mg. On the very first injection I ate a huge breakfast and paid dearly. The last stage has been a tad rough. You can’t slip up one bit or you will feel the nausea and either constipation or diarrhea. Seriously! Makes you eat really well

I'm taking tirzepatide, and yup, nausea and constipation. Gets worse every time I titrate up, so I did increased dosage about half as fast as the clinical trials tested, never got to max dose available, stopped at my goal, and have just started dropping down to find a maintenance dose. In my case, the impacts are clearly dose-dependent.

I'm prone to constipation, and I'll second the 250 mg ducosate recommendation. Also occasional miralax. I've also got a recipe for a home-made product made with dried fruit and senna tea I picked up from a friend with Parkinson's. And I'm largely done with white flour and refined grains, because I need the fiber from groats and whole grain flour.

My primary care physician gave me a nausea prescription for ondansetron, which I use when it is really important to me to not abandon a meal a dozen bites in, such as going out to eat with friends and family. It works quite well. Beyond that, I've got an odd vagus nerve behavior -- I know when to stop trying to power through when I start sneezing. Fortunately, there is negligible delay between triggering food and symptoms, so I've learned pretty quickly which foods are more benign for me than others. (These may not be logical. Most of the time, I can't do soft grain products like bread and pancakes, but I can do toast and crackers. I can do broccoli most of the time, but brussels sprouts only when I'm feeling particularly symptom-free. Trust your own gut.)

I've learned to prioritize protein early in the meal, since these drugs are known for muscle mass impact. I'm also taking a bariatric multi-vitamin.

Apparently some people find that if they switch between GLP-1 RAs, that helps -- they have fewer side effects with some than others. That's my fallback, although I'm not there yet.

Since taking my injection in my thigh and at bedtime no nausea

Good point. I've heard that before -- thigh is slightly less effective, but minimizes side effects. Haven't thought about time of day. I'll have to give that a try.

@srwolfe
I'm really interested in the responses as well. I start my 1.7 WEGOVY next week. No side effects so far and little impact on appetite.

I am reading several posts about injections in thighs. I had not heard this was a better site for side effects. Would this not be closer to muscle mass than stomach? I am hoping my 1.7 starts to decrease appetite and snacking. It has reduced dinner appetite but not snacking afterward.

Am I expecting too much from WEGOVY?

I've been on the 1.7 for 3 months. I ALWAYS vomit & stay in bed the day after the shot. Dr appointment tomorrow & will discuss with him. I also stay Extremely Tired ALL THE TIME. I'm considering going off Wegovy. I've lost 32 lbs since July.

@wynnejo
At least you did lose some weight on it.

I agree if were me I would come off also. That is way to much side affect that I could deal with.

Does your doctor think a different maker would have less side effect. I don't think I have the right name but mine mentioned enbound (spell) or something like that saying was more toward the signals to brain versus the full feelings with less side effects.

I am trying hard to do it on my own.
Good luck and if you don't mind let me know what your doctor says and if recommends something different.

For what it's worth -- one person's experience only -- I titrated very slowly up (a lot slower than the studies called for) on tirzepatide (zepbound), and then titrated slowly down after I hit my goal weight, and never lost the side effects. Which to be fair, never included vomiting regularly, so I'm stunned you've kept it up, which is amazing dedication.

The worst side effect for me (among many) was my turbocharged migraines. I've had migraines for pushing 60 years now, but I had never gotten to the point where I was taking three preventives and my rescue meds stopped working.

Finally switched to semaglutide (ozempic, which is the same as wegovy but uses a different dispenser) about a month ago. I'm titrating up. Interestingly, I'm hitting some side effects, but they are different side effects. (My migraines have largely stopped, for example, while the light-headedness is a lot worse. After discussing it with my doctor, I stopped simvastatin, and it's made a substantial difference to the light-headedness. In fact, I've now got an entire plan in the works to stop or change almost every other drug I'm on, several weeks apart, to see what happens, since I really don't want to stop the GLP-1 RAs.)

At any rate, you might consider either titrating down on the wegovy to gradually lower doses, or switching to zepbound (tirzepatide), or do the first one followed by the second one. Unfortunately, and for obvious commercial reasons, no one has actually done a study to provide guidance for any of that. Therefore, it's all a judgment call. I titrated all the way down to the lowest dose of zepbound, and then started on the lowest dose of ozempic. No one actually knows whether this is the best approach, but it seemed to make sense to me.

Finally, if you do want to try switching, you might consider asking for a Mounjaro Kwikpen instead of Zepbound if you are not constrained by your insurance plan. This is because the Kwikpen allows you to fine-tune your dosages, just like the Ozempic multi-pen does (and which Mounjaro and Zepbound don't). If you want more on that, just let me know. Be aware that both manufacturers strongly oppose doing that, but I'm doing it anyway.