Trelegy

@km6 I'm not sure you will get too many responses here about Trelegy - it is most commonly used for COPD and severe asthma, and since it contains an ICS (inhaled corticosteroid), most Bronchiectasis patients are advised to it. The steroid is thought to lower ability to fight off infection.

I take Symbicort, which is similar but only contains two medications, and it actually improved my chest tightness, but didn't completely relieve it.

Are you still using albuterol before you neb saline and do airway clearance? That extra "shot" of bronchodilator can sometimes cause airway spasms. According to my pulmonologist, it may not be necessary if you are using long-acting inhaler like Trelegy.

I afm using Trelegy as a " last resort", having tried almost every inhaler made. Im someone that albuterol doesn't help.. no reaction to it. Have bronchiectasis, perhaps a touch of COPD, and sometimes MAC.
For the past 2 1/2 years I have been continuously extremely tired and unable to walk very far and only with cane or walker. (I don't have other ailments but lung problemsl).
2 weeks ago I started Trelegy and it has been a miracle. Lots of energy to the extent I don't need Walker and use a cane only in the dark. It's like the first few days of a prednisone taper but better,. I'm still slow and limited compared to a well person . And am so much better compared to pre-Trelegy.

Trelegy is working fine for me as well. Started it 11/21 and so far so good. It’s nice having 1 inhaler instead of 3!

Thank you. I have been on trelegy for a couple of years. My pulmonologist has basically tried all of the other inhalers. They struggle to figure out how to help me. I worry about the steroid, as I have very thin skin that tears easily. I'm sadly aware of the danger of steroids, in addition, I'm on prednisone two or three times a year for exacerbations. I do not have a definitive diagnosis of Mac, but it is suspected. I am getting ready to have cardiac testing to rule out cardiac involvement. I can tell my disease is progressing because of my breathing. I forced myself to walk every single day. I take care of my house and my dog and do everything I can. I alternate between frustration and fear.

I'm happy to hear the trelegy works so well for you. In addition to the trelegy, I have to neb levabuterol and I use my rescue inhaler. I know my disease is progressing because it takes more to keep me breathing. So extremely frustrating dealing with all this.

I’m fortunate that I rarely use rescue meds like any form of albuterol except during exacerbations. It really spikes my heart rate when I do use rescue meds. My fingers are crossed that Trelegy keeps working for me—one inhaler is fewer to remember than 3, especially only once daily instead of some twice daily.

What we are really hoping is that trelegy reduces my exacerbations. I’ve had 3+ in the past 12 months and none of us are happy about that.