Statin Side-effects: Muscle pain and weakness

Posted by ginnyjm @ginnyjm, Nov 12 7:34pm

I’ve been on a statin drug for over 25 years. In the last year my legs have gotten very weak & painful. I now have to use my arms to get out of a chair & it’s still difficult. Can the side effects start after I’ve taken the statin for so long? Anyone else have this sudden problem?

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@writerbroad

Statins definitely lower cholesterol (which have a very real positive role in our bodies), but the higher cholesterol is a symptom, not a cause. It's like taking high-powered pain killers to alleviate the pain of a brain tumor. That does nothing to cure the tumor. Lifestyle changes are the only treatment that works. And the side effects are terrific: normal body weight, more energy, healthy blood sugar levels -- and on and on. You might notice that the statin drug ads seemed to have stopped emphasizing curative powers, only that they reduce cholesterol. I am aware that many physicians disagree with me. My own cardiologist, who had been in practice for 50 years when he retired last year, insisted that 98% of his patients have no side effects with statins. My personal experience is that everyone I know that has been on them has stopped taking them because of side effects. Whoops! I take that back. The husband of a friend is now on 20 prescriptions, the result of adding prescriptions to treat the side effects of other prescriptions. The cholesterol hypothesis (yes, it's just a theory) is only one of several theories about the causes of heart disease. Not surprisingly, stress and emotions are far and away more responsible for heart disease than something as simple as cholesterol levels. For a summary of the many studies that refute the importance of cholesterol levels in heart disease, I have two main sources. The scientific community that titles itself "The International Network of Cholesterol Skeptics," whose members are among the world's most distinguished and respected medical practitioners and researchers, have published several books. I read LIPID LUNACY: DIET DELUSIONS AND WHAT REALLY CAUSES HEART DISEASE. An easier read is THE GREAT CHOLESTEROL MYTH by Bowden and Sinatra. Bowden's degrees and research are primarily dietary and some of his essays are featured on the Mayo Clinic website. Sinatra was a cardiologist, as well as a licensed psychotherapist. Statins are a very powerful antioxidant, which accounts for their theoretical use in heart disease, which is an inflammatory disease. They definitely do an exemplary job as an anti-inflammatory. But at what cost? Since sugar is such a powerful inflammatory substance, it's no surprise that reducing sugar intake is helpful. Some 40 years ago, I quit smoking by eating chocolate chip cookies instead. After a year of carrying all the weight I gained during that time, I went on a diet that began with a water fast, then a balanced diet that allowed no alcohol or sugar. I not only dropped all the weight, but I felt like a million dollars. It was years later that I learned of sugar's inflammatory effect. That's when I realized why the arthritis that had begun in my finger joints completely disappeared during my diet.

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I have been on statins for over 30 years and never had any side effects. I'm currently on Simvastin. 2 years ago I did a 6 week nutrition and fitness challenge and never looked back. I cut out carbs (bread, pasta, potato chips), increased my protein, eat within an 8 hour window (really helped with stopping the evening snacking), and make sure I stay well hydrated all day. I also started strength training with weights (dumbells) 4 times a week in addition to the daily walking I do with my dog. Having dog is a great motivator to get out into nature every day regardless of the weather! I lost 27 pounds and feel great. However, my cholesterol levels are still too high. My father and both my siblings also had high cholesterol and I recently heard on a Ted Talk Podcast that there is a genetic test to see if you have that gene, but most likely not covered by insurance. I try not to worry about the cholesterol as it's borderline high, but it's always in the back of my mind. I am going to ask my PCP at my January 2025 annual exam if there is a better statin to take as this one doesn't seem to do much. It's really been my diet changes and exercise that have lowered. Any suggestions?

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I had the Lipoprotein A which checks your risk. Mine was 267 which is high, genetics made it go high. I am taking Pitavastatin 1mg once a day at night with CoQ10. I started it one week ago. My lipids were in normal range thanks to the Mediterranean diet, exercise, I don’t drink alcohol (only water) and I have never smoked. My parents had heart disease. This is the reason he put me in a statin. I have lost 30 pounds so far.
Thanks for your input.

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@maggie8358

I have been on statins for over 30 years and never had any side effects. I'm currently on Simvastin. 2 years ago I did a 6 week nutrition and fitness challenge and never looked back. I cut out carbs (bread, pasta, potato chips), increased my protein, eat within an 8 hour window (really helped with stopping the evening snacking), and make sure I stay well hydrated all day. I also started strength training with weights (dumbells) 4 times a week in addition to the daily walking I do with my dog. Having dog is a great motivator to get out into nature every day regardless of the weather! I lost 27 pounds and feel great. However, my cholesterol levels are still too high. My father and both my siblings also had high cholesterol and I recently heard on a Ted Talk Podcast that there is a genetic test to see if you have that gene, but most likely not covered by insurance. I try not to worry about the cholesterol as it's borderline high, but it's always in the back of my mind. I am going to ask my PCP at my January 2025 annual exam if there is a better statin to take as this one doesn't seem to do much. It's really been my diet changes and exercise that have lowered. Any suggestions?

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My younger son has had high cholesterol all his life. His doctor in Australia told him to take Bergamot (an Italian citrus in pill form that is available in health food stores). People on high blood pressure medication cannot eat grapefruit, so that also applies to this supplement. Don't take it if you are on blood pressure meds. It makes them more powerful and thus can cause dangerous low blood pressure! I was advised that triglycerides are more important than cholesterol scores. Formula I was given was to divide triglycerides by HDL. If it is 2.1 or lower I'm in good shape. Okay at 3.5, and really bad at 5.1. When I was losing weight during cancer treatments, the doctors pressured me to gain weight and I added a lot of junky things to my diet that I wouldn't normally eat in an attempt to get my calories up. My triglycerides went through the roof. My last test showed they are coming down, but still a bit high.

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https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/drug-cabinet/statins?mi_u=8-15489347
https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin
https://pubmed.ncbi.nlm.nih.gov/26299317/
As the above sites and article/abstract suggest, it is okay to have grapefruit with some kind of statins, but one should be very careful with the other kinds. Atorvastatin, for example, is one such problem-statin. You can have up to one 8 oz glass of juice or a whole grapefruit, but you may want to have it several hours after ingesting the statin dose. I saw another article a few weeks ago saying the risk of grapefruit with any statin was overblown, but I can't find it.

In any event, please follow the guidelines issued with your prescription, and/or follow your doctor's advice if it differs from the pamphlet accompanying the product.

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Statins- ongoing muscle pains since I started this drug. I had to lower the dose. Cholesterol is great with meds and diet. I do take CQ10 supplement with Vit. D daily.

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@naiviv

I hzve been reading so much about statins that I was hesitant to take them but knowing my risks because of my genes, my cardiologist prescribed me a low statin the lowest dose, pitavastatin 1mg daily at night and to take it with CoQ10. I started last night. Will see. Thanks for your input. Stay well.

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Naiviv, I have tried to take all stations and can not for the muscle cramps and weakness of my legs, I know of other women that have experienced the same. They are hard on woman, keep watch.

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@writerbroad

Statins definitely lower cholesterol (which have a very real positive role in our bodies), but the higher cholesterol is a symptom, not a cause. It's like taking high-powered pain killers to alleviate the pain of a brain tumor. That does nothing to cure the tumor. Lifestyle changes are the only treatment that works. And the side effects are terrific: normal body weight, more energy, healthy blood sugar levels -- and on and on. You might notice that the statin drug ads seemed to have stopped emphasizing curative powers, only that they reduce cholesterol. I am aware that many physicians disagree with me. My own cardiologist, who had been in practice for 50 years when he retired last year, insisted that 98% of his patients have no side effects with statins. My personal experience is that everyone I know that has been on them has stopped taking them because of side effects. Whoops! I take that back. The husband of a friend is now on 20 prescriptions, the result of adding prescriptions to treat the side effects of other prescriptions. The cholesterol hypothesis (yes, it's just a theory) is only one of several theories about the causes of heart disease. Not surprisingly, stress and emotions are far and away more responsible for heart disease than something as simple as cholesterol levels. For a summary of the many studies that refute the importance of cholesterol levels in heart disease, I have two main sources. The scientific community that titles itself "The International Network of Cholesterol Skeptics," whose members are among the world's most distinguished and respected medical practitioners and researchers, have published several books. I read LIPID LUNACY: DIET DELUSIONS AND WHAT REALLY CAUSES HEART DISEASE. An easier read is THE GREAT CHOLESTEROL MYTH by Bowden and Sinatra. Bowden's degrees and research are primarily dietary and some of his essays are featured on the Mayo Clinic website. Sinatra was a cardiologist, as well as a licensed psychotherapist. Statins are a very powerful antioxidant, which accounts for their theoretical use in heart disease, which is an inflammatory disease. They definitely do an exemplary job as an anti-inflammatory. But at what cost? Since sugar is such a powerful inflammatory substance, it's no surprise that reducing sugar intake is helpful. Some 40 years ago, I quit smoking by eating chocolate chip cookies instead. After a year of carrying all the weight I gained during that time, I went on a diet that began with a water fast, then a balanced diet that allowed no alcohol or sugar. I not only dropped all the weight, but I felt like a million dollars. It was years later that I learned of sugar's inflammatory effect. That's when I realized why the arthritis that had begun in my finger joints completely disappeared during my diet.

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Great post. I learned a lot. Thanks.

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@desi27

Statins- ongoing muscle pains since I started this drug. I had to lower the dose. Cholesterol is great with meds and diet. I do take CQ10 supplement with Vit. D daily.

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If I may ask which statin did your physician prescribe to you? I have heard that if the physicians lower the dose of any statin, there is much relief.

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@daisy22

That is a common side effect. Both my husband and I stopped taking statins and the pain went away. Doctors always act like this is something new or unheard of. I wish our clinic had a PharmD to talk to about prescriptions. Good luck.

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how long did it take for the pain to go away? approx?

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@naiviv

If I may ask which statin did your physician prescribe to you? I have heard that if the physicians lower the dose of any statin, there is much relief.

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My cholesterol was borderline and I took a statin for three days and thought I felt weird! I went to online info, started taking OTC Red Yeast Rice (low dose) and a garlic tablet daily. In 6 months my cholesterol was down 20 points, well within normal range! No side effects!

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