Statin Side-effects: Muscle pain and weakness

Posted by ginnyjm @ginnyjm, Nov 12 7:34pm

I’ve been on a statin drug for over 25 years. In the last year my legs have gotten very weak & painful. I now have to use my arms to get out of a chair & it’s still difficult. Can the side effects start after I’ve taken the statin for so long? Anyone else have this sudden problem?

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@crystalblue

Back in the day, we had a country doctor who cared for all the young and old folks, birth and death. Lab work didn't exist for us, nor was there any cholesterol knowledge. None of us took any medication other than natural things that folklore mentioned for what ailed us. Most of the community lived a long life. The age of 80 to the high 90's wasn't unusual. I remember my grandpa frying up sausage patties and then pouring the grease on his flapjacks instead of syrup. We buried him when he had just turned 94. No heart attacks or strokes. Copperhead bite got him. Sometimes not knowing what ales you keeps you better off than taking all kinds of medications that may have side effects making you worse off than when you started.

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Amen to that.

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@willjean19

You may try to change your statin? I know some individuals that have good luck on the injectable Repatha used bi-weekly. Your concern is valid as it can be a side effect in up to 20% of individuals I have read. As others mentioned, change in diet, exercise etc may be beneficial

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I have a brother-in-law that tried every statin there is and couldn't take any of them. He was put on Repatha and is loving it. Your doctor has to prove that you have tried everything on the planet first to get it covered

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@gussie

I have a brother-in-law that tried every statin there is and couldn't take any of them. He was put on Repatha and is loving it. Your doctor has to prove that you have tried everything on the planet first to get it covered

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Definitely worth pursuing from what I understand l; however can be expensive

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@rashida

@slkanowitz do you have to inject the Repatha yourself, or does your doctor do it? I wonder if a pharmacist would do it … I hate self injecting!

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Repatha comes in a Sure Click form that makes self injection easy. It’s a prefilled cartridge and all you do is wipe skin ( I use abdominal fat) with alcohol swab, press cartridge hard against skin and push button. Anyone in family can do it for you as well. It’s fast, easy, but stings for a couple of seconds.

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@poppy55

Have you had scans to see if you have plaque buildup in your arteries? That is the main issue. A friend of mine has very high cholesterol but no blockages so he does fine without statins. I recently switched to Praluent due to muscle weakness with Crestor, but the side effects are much worse. I am going to go back to a low dose of Crestor. Unfortunately I have blocked arteries so I don’t feel comfortable going off statins completely.

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I don't do scans. I do not take meds because side effects usually worse than the issue. .

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@naiviv

Anyone with muscular issues while taking statins? Did the doctor stopped you from taking it? I am taking pitavastatin 1mg daily and have experienced muscle soreness. I have not taking CoQ10 yet. Any input? Thanks

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Hello @naiviv, I combined your two discussions on Statins and the side-effect of muscle pain and weakness and moved them to an existing discussion by @ginnyjm titled, "Statin Side-effects: Muscle pain and weakness" - https://connect.mayoclinic.org/discussion/statin-drugs-side-effects/.

By combining all of the messages, members who are discussing muscle pain and weakness while on statins can meet one-another. You've already met @gloaming. @harveywj and @ggrogers have also shared their experiences as well.

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Thanks, I've about given up on Statins, maybe Repatha is something I can tolorate.

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@poppy55

Have you had scans to see if you have plaque buildup in your arteries? That is the main issue. A friend of mine has very high cholesterol but no blockages so he does fine without statins. I recently switched to Praluent due to muscle weakness with Crestor, but the side effects are much worse. I am going to go back to a low dose of Crestor. Unfortunately I have blocked arteries so I don’t feel comfortable going off statins completely.

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Statins definitely lower cholesterol (which have a very real positive role in our bodies), but the higher cholesterol is a symptom, not a cause. It's like taking high-powered pain killers to alleviate the pain of a brain tumor. That does nothing to cure the tumor. Lifestyle changes are the only treatment that works. And the side effects are terrific: normal body weight, more energy, healthy blood sugar levels -- and on and on. You might notice that the statin drug ads seemed to have stopped emphasizing curative powers, only that they reduce cholesterol. I am aware that many physicians disagree with me. My own cardiologist, who had been in practice for 50 years when he retired last year, insisted that 98% of his patients have no side effects with statins. My personal experience is that everyone I know that has been on them has stopped taking them because of side effects. Whoops! I take that back. The husband of a friend is now on 20 prescriptions, the result of adding prescriptions to treat the side effects of other prescriptions. The cholesterol hypothesis (yes, it's just a theory) is only one of several theories about the causes of heart disease. Not surprisingly, stress and emotions are far and away more responsible for heart disease than something as simple as cholesterol levels. For a summary of the many studies that refute the importance of cholesterol levels in heart disease, I have two main sources. The scientific community that titles itself "The International Network of Cholesterol Skeptics," whose members are among the world's most distinguished and respected medical practitioners and researchers, have published several books. I read LIPID LUNACY: DIET DELUSIONS AND WHAT REALLY CAUSES HEART DISEASE. An easier read is THE GREAT CHOLESTEROL MYTH by Bowden and Sinatra. Bowden's degrees and research are primarily dietary and some of his essays are featured on the Mayo Clinic website. Sinatra was a cardiologist, as well as a licensed psychotherapist. Statins are a very powerful antioxidant, which accounts for their theoretical use in heart disease, which is an inflammatory disease. They definitely do an exemplary job as an anti-inflammatory. But at what cost? Since sugar is such a powerful inflammatory substance, it's no surprise that reducing sugar intake is helpful. Some 40 years ago, I quit smoking by eating chocolate chip cookies instead. After a year of carrying all the weight I gained during that time, I went on a diet that began with a water fast, then a balanced diet that allowed no alcohol or sugar. I not only dropped all the weight, but I felt like a million dollars. It was years later that I learned of sugar's inflammatory effect. That's when I realized why the arthritis that had begun in my finger joints completely disappeared during my diet.

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@writerbroad

Statins definitely lower cholesterol (which have a very real positive role in our bodies), but the higher cholesterol is a symptom, not a cause. It's like taking high-powered pain killers to alleviate the pain of a brain tumor. That does nothing to cure the tumor. Lifestyle changes are the only treatment that works. And the side effects are terrific: normal body weight, more energy, healthy blood sugar levels -- and on and on. You might notice that the statin drug ads seemed to have stopped emphasizing curative powers, only that they reduce cholesterol. I am aware that many physicians disagree with me. My own cardiologist, who had been in practice for 50 years when he retired last year, insisted that 98% of his patients have no side effects with statins. My personal experience is that everyone I know that has been on them has stopped taking them because of side effects. Whoops! I take that back. The husband of a friend is now on 20 prescriptions, the result of adding prescriptions to treat the side effects of other prescriptions. The cholesterol hypothesis (yes, it's just a theory) is only one of several theories about the causes of heart disease. Not surprisingly, stress and emotions are far and away more responsible for heart disease than something as simple as cholesterol levels. For a summary of the many studies that refute the importance of cholesterol levels in heart disease, I have two main sources. The scientific community that titles itself "The International Network of Cholesterol Skeptics," whose members are among the world's most distinguished and respected medical practitioners and researchers, have published several books. I read LIPID LUNACY: DIET DELUSIONS AND WHAT REALLY CAUSES HEART DISEASE. An easier read is THE GREAT CHOLESTEROL MYTH by Bowden and Sinatra. Bowden's degrees and research are primarily dietary and some of his essays are featured on the Mayo Clinic website. Sinatra was a cardiologist, as well as a licensed psychotherapist. Statins are a very powerful antioxidant, which accounts for their theoretical use in heart disease, which is an inflammatory disease. They definitely do an exemplary job as an anti-inflammatory. But at what cost? Since sugar is such a powerful inflammatory substance, it's no surprise that reducing sugar intake is helpful. Some 40 years ago, I quit smoking by eating chocolate chip cookies instead. After a year of carrying all the weight I gained during that time, I went on a diet that began with a water fast, then a balanced diet that allowed no alcohol or sugar. I not only dropped all the weight, but I felt like a million dollars. It was years later that I learned of sugar's inflammatory effect. That's when I realized why the arthritis that had begun in my finger joints completely disappeared during my diet.

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Good points. I too have radically changed my diet, and I’d like to think that is enough. Low fat, no alcohol, lots of exercise. Without statins my LDL dropped to 90, but my cardiologist wants it to be lower. I have tried several statins and finally tried Praluent, which has made me feel even worse. I’m going to try a minimal dose of Crestor (5mg) and if that still produces these side effects I’m going to stop and focus on being healthy. Thank you for the encouragement.

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@writerbroad

Statins definitely lower cholesterol (which have a very real positive role in our bodies), but the higher cholesterol is a symptom, not a cause. It's like taking high-powered pain killers to alleviate the pain of a brain tumor. That does nothing to cure the tumor. Lifestyle changes are the only treatment that works. And the side effects are terrific: normal body weight, more energy, healthy blood sugar levels -- and on and on. You might notice that the statin drug ads seemed to have stopped emphasizing curative powers, only that they reduce cholesterol. I am aware that many physicians disagree with me. My own cardiologist, who had been in practice for 50 years when he retired last year, insisted that 98% of his patients have no side effects with statins. My personal experience is that everyone I know that has been on them has stopped taking them because of side effects. Whoops! I take that back. The husband of a friend is now on 20 prescriptions, the result of adding prescriptions to treat the side effects of other prescriptions. The cholesterol hypothesis (yes, it's just a theory) is only one of several theories about the causes of heart disease. Not surprisingly, stress and emotions are far and away more responsible for heart disease than something as simple as cholesterol levels. For a summary of the many studies that refute the importance of cholesterol levels in heart disease, I have two main sources. The scientific community that titles itself "The International Network of Cholesterol Skeptics," whose members are among the world's most distinguished and respected medical practitioners and researchers, have published several books. I read LIPID LUNACY: DIET DELUSIONS AND WHAT REALLY CAUSES HEART DISEASE. An easier read is THE GREAT CHOLESTEROL MYTH by Bowden and Sinatra. Bowden's degrees and research are primarily dietary and some of his essays are featured on the Mayo Clinic website. Sinatra was a cardiologist, as well as a licensed psychotherapist. Statins are a very powerful antioxidant, which accounts for their theoretical use in heart disease, which is an inflammatory disease. They definitely do an exemplary job as an anti-inflammatory. But at what cost? Since sugar is such a powerful inflammatory substance, it's no surprise that reducing sugar intake is helpful. Some 40 years ago, I quit smoking by eating chocolate chip cookies instead. After a year of carrying all the weight I gained during that time, I went on a diet that began with a water fast, then a balanced diet that allowed no alcohol or sugar. I not only dropped all the weight, but I felt like a million dollars. It was years later that I learned of sugar's inflammatory effect. That's when I realized why the arthritis that had begun in my finger joints completely disappeared during my diet.

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I liked your input. As a matter of fact a cardiologist that I used to visit before I decided to move to another state told me that statins are meant for inflammation not cholesterol numbers. The statins work on the arteries’ walls reducing any inflammation caused by stress or crazy hormones and chemicals that affect them. My lipids are normal but in my case I have high risk of heart disease due to the cardiac history of my parents. I never liked them but recently because of my age (72) and my genes, my cardiologist prescribed me a low intensity statin, Pitavastatin 1mg daily at night. I continue with the Mediterranean diet, (fruits, vegetables, no red meat, only fish, chicken, turkey), exercising for 1 hr daily, no alcohol, no sweets, no fats. I have never smoked. I only drink water even at weddings when everyone is getting drunk🤣. I have lost 35 pounds and so far I love what I am doing and don’t have side effects with the statin(crossing fingers & knocking on wood). My brother was having issues with his statin and now that his doctor lowered the strength he feels much better, he takes Crestor.
Our grandparents lived a great life, used to eat fresh food from their garden and we never saw them taking so many medications. The preservatives that we find nowadays in our food are horrendous and have contributed to so many illnesses. Check the TV documentary on Netflix “BLUE ZONES” countries in the world where its habitants lived to 100 yrs. The most interesting documentary I have ever seen.
Thank you for the information. Stay well.

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