Reclast Infusions: Side-effects & Recovery time

@whiteswan how recently did you finish Prolia and do the Reclast? How bad is your bone density? Can your doctor prescribe a half dose? You can drink a lot of water (not too much!) and have the same effect as IV hydration. The doctor (I assume a doctor ordered the Reclast) has to order the slow infusion, the dose, and any IV hydration in my experience. If anyone else was able to get the nurse to slow the infusion without a doctor's order, I hope they will respond.

My Reclast infusion was five days ago. I was very hydrated and on Tylenol regimen. Had some aches, but no fever.
Still a little more achy than on any other day.

I'm glad to see this post. I had a Reclast infusion 1/28/24 and also have had right knee and leg pain for the last couple of months. I've researched to see if this is common but haven't had much success so thank you for sharing. It is also worse at night and after sitting for any length of time. When I stand, it feels like my leg can't initially support me then it gets better after walking. Many years ago I had taken Fosamax for several months then had a similar situation-right leg pain and trouble walking. It didn't last very long after I discontinued it. I took a chance on the Reclast after a worsening DEXA but now don't know if I should take it again next January. I hope to follow this post and see if anyone has insight here.

I had bookmarked this information from a previous post @gently made regarding reclast infusion. I didn’t copy the entire post, just the information pertinent to reclast infusion instructions.

From @gently
I have some advice from a doctor at Stanford about how to take Reclast to diminish side effects. He ran the clinical trials on Reclast. So this passage which I quote is meticulous. Don't let the complexity stir you against the drug. You might print the instructions and give them to the prescribing administering medical personnel, if you decide on Reclast. He also prefers Reclast after the full Forteo or Tymlos 18 months.
I won't take Evenity or Prolia. Although, if there were nothing else. . . I'm no so happy about the mechanism of action of the bisphosphonates. And am trying to figure a way without them.

"Have the infusion nurse dilute the 5mg in 100m LD5W into 500mLof NS so that the now 600mL infuses over 60 minutes.
Making the N-BP liss concentrated and infusing it more slowly substantially improves the renal safety based on data.
Administer 650mg of acetaminophen at the same time of the infusion and instruct the patient to take the same dose with dinner and at bedtime the day of the infusion, and with all three meals and at bedtime the day after the infusion, and a final dose with breakfast the 2nd morning after the infusion. This reduces the risk of a symptomatic acute phase reaction (APR) from about 22% to < 1%.
The 3rd thing I do is repeat the BTM (bone turnover markers) U, NTx and serum BSAP 4-6 weeks after the infusion to assess the maximal effect of bone turnover rate. This serves as a comparison when I repeat BTMs 12 months after the infusion. In my extensive 32 years of experience with IV bisphosphonates the average woman only needs a second infusion after an average of 24 months."

I feel very fortunate. I had my first Reclast infusion on May 9. I had a few aches the next day but nothing serious. No side effects that I'm aware of since then. I did ask the nurses for a longer infusion and they were fine with that. I asked for one hour. I drank considerable water the day before and day of. I did take one or two Tylenol. I am so sorry for those who did not have an easy time.

dna41, I also feel fortunate. My Reclast infusion was six days ago. I followed instructions and had minimal side effects. Some aches and pains that were new, but that has subsided.
I had enough aches and pains already that it’s hard to tell what is Reclast and what isn’t.
I have a lot of arthritis in my right hand. Yesterday it was really bad. Today - gone.
Each day is a surprise.
Still, I was fortunate regarding Reclast.
Best to everyone on this journey.

I had my first Reclast infusion Feb. 2022 due to a poor dexa. I'm pretty sure it was a slow infusion and painless at the time (at least an hour or more) . However, I was so sick the next day, under the covers sick and calling the doctor on a Sunday! She said it means it's working. My next routine bloodwork showed PTH levels were extremely off and had to have some imaging. Although, the Doctor claimed it was the lab, I did not think so. However, before I was due to go for another infusion (a year later), I opted for a repeat dexa which showed all was well and it was not necessary to have a 2nd Reclast. PTH has since been normal. I will have a repeat Dexa when I'm covered under insurance, but will have Reclast again IF necessary and follow the latest suggestions here. Has anyone else had PTH levels go to extreme?

To summarize;

Drink 80-100 oz of fluid the day before.

Tylenol 3x the day before.

Before Reclast, drink at least 2 glasses of fluid (such as water) within a few hours

Hydration IV one hour before Reclast.

60 minute Reclast infusion.

Question:

What are your thoughts about-Dexamethasone for four days. (One the day before.)

How long should the saline drip be after Reclast infusion?

I ended up in the ER severe spine pain. It was the worst pain I have ever experienced. After tons of test I was sent home with a diagnosis of allergic reaction to reclast. It lasted about 14 days.