Tymlos pro/cons

I'm 70 and have been diagnosed with Osteoporosis. I also have PMR (Polymyalgia Rheumatica) and have been taking low doses of Prednisone for over a year. I'm down to 1 mg and hope to be able get off prednisone soon. My Rheumatologist has recommended Prolia. Reading about the possible side effects has me terrified to get the shot. I came up upon Tymlos as an alternative although daily shots aren't appealing to me. I don't know what to do. I know I need to do something.

I've been on a full dose for 4 months, no side effects. Seems to vary a lot from person to person!

Thank you for your response. Of Tymlos or Prolia?

just commenting about the daily injections: "nothing burger" for me. I only do them in my thighs. As I was noticing some visceral fat in my belly and there were comments about that in another forum. Plus, I had cervical spine surgery and impossible to SEE my belly! I am super sensitive to meds. So I suggest you try it, with support and you can always stop! (no pain, no gain!) good luck.

Good morning - as I have come to learn - inflammatory reactions are not swelling reactions. Two separate things. Quickly grabbed this explanation:
"Swelling is any abnormal enlargement of a body part. It is typically the result of inflammation or a buildup of fluid. Edema describes swelling in the tissue outside of the joint. Effusion describes swelling that is inside a joint, such as a swollen ankle or knee."
More: (I think of it as my nerves being triggered) and if left unchecked it will turned to swelling (edema pressure). But I agree, they are hard to untangle and happen together and we don't think about the separation.
Switching was mentioned but I have to check. Forteo also had issues - don't want to jump the frying pan into the fire! just yet! (they won't let me post the link but you can google the differences between swelling and inflammation.

@michelem I have lupus and my docs won't prescribe Prolia for me. Other arguments against Prolia from my doctors and from Keith McCormick's book "Great Bones": there is a rebound when you go off Prolia (the longer you go the worse it is, they say) meaning without an effective follow-up with Reclast (or Fosamax) you can end up worse than you started.

Prolia is not a bone builder. It is an anti-resorptive that works by reducing bone turnover. It increases density but not with new bone. Forteo and Tymlos are bone builders, and Evenity is for the first half. This is what has been explained to me.

If you need a bone builder later, Prolia may also affect the effectiveness of those other drugs to some extent.

I am curious why your rheumatologist suggested Prolia. Did they feel it was best in the context of PMR and steroid use? Are you considering seeing an endocrinologist?

Another good resourse is Dr. Ben Leder's YouTube video "Combinations and Sequencing Approaches to Osteoporosis>"

I tolerated Tymlos well be starting at a low dose and moving up. The pen has adjustable doses. The needle is tiny. The half life is one hour so it leaves your body quickly.

Toradol reduces inflammation which has the effect of reducing swelling but with a reputation of increasing edema. Inflammation, swelling or edema can exert painful pressure on nerves.
Some patients are allergic to the preservative in Tymlos.

Very, very helpful information. Thank you. I ordered the recommended book, and it should be arriving today. I'll also check out those videos. I inquired about Tymlos which my Dr. also mentioned. I would go in monthly for 6 months. He said afterwards I would need to go on another medication as if that isn't the case with Prolia. Sure hoping I get some clarification with reading the book and watching the videos. If only I could take my Dr.'s recommendation and go with that. Thanks again.

I have had terrible nose-blowing and runny nose. RE: Mention of the allergies to preservatives in Tymlos: how would I know if it's directly related? It does seem a little odd that I have such hay-fever rhinitis-type symptoms after pollen season but California has had a long rainy season. I have been given toroidal for over 20 years during extreme pain (sciatic). I already had edema growing up. I noticed no additional edema problems, but the use is extremely short. Either one injection or a few days of oral use. The problem with my dental nerves became exacerbated by the Tymlos. I only know because I stopped after a month and the pain went away completely and then slowly set in again when I started over the week. However - let me say - I would have to stop one more time to be conclusively sure. The pain was thru the roof unbelievable! I looked all my symptoms up and they tied to "trigeminal neuralgia." I woke up better today. No teeth sensitivity with my coffee. No pain when I press on anything from the outside with my fingers.. Still some gum/pressure swelling when I press with my tongue on the right upper molar side to the back. We'll see what happens over the course of the day.
Funny thing is -- my lumbar back pain is back. It disappeared while I had the severe cranial tooth thing going on. So funny the way pain works!

My endocrinologist said the half life is 12.5 hours. I looked it up. You are correct!!!! DANG. I hate it when I can't trust them. But, with me it does feel like my adverse reactions last the day which was why I was told to move it to evenings. Thank you.