As promised, my successful tapering off Effexor (Venlafaxine)

Posted by sheffieldsmith @sheffieldsmith, May 31, 2020

Below you will find the tapering plan that I used to successfully wean myself off Effexor (Venlafaxine). Feel free to share this with your doctor If you would like. I researched and came up with this plan, which was approved by my doctor, although she thought I could probably have weaned myself off sooner. But the reality is that we all have differing tolerance levels for tapering and weaning off this powerful drug from our bodies. Some people can taper faster, but usually not those who have been on this drug for years (like myself, since October 2002). I tapered off EffexorXR 150mg capsules about 5 years ago down to 75mg, and was on that maintenance dosage for a couple of years until I started weaning off the 75mg a year ago in April 2019. As of October, 2029, I’ve been withdrawal symptom free, but I still have occasional periods of anxiety when triggered. But I realize these waves of anxiety will soon pass, and I cope by deep breathing, taking a walk, having a cup of chamomile tea, etc. Cutting my exposure to watching upsetting news has really helped a lot as well. These days I seek things that bring joy and peace in such a turbulent world. Wishing you all a successful weaning off this powerful drug.

Weaning off Venlafaxine XR 75mg (Effexor-(extended release)capsules:
Weaning plan off plan that worked for BSS:
1. Inform your doctor you are tapering down from 75 mg Venlafaxine and ask them to prescribe 37.50 tabs to help with tapering doses (1/2 dosage down from 75 mg Venlafaxine capsules). The tabs are easier to cut into halves and quarter dosages than counting out beads from the capsules.
2. Begin your taper only after you are on a non-withdrawal symptomatic dosage level. If you were having w/d symptoms at 75 mg, you’ll need to go back to the level at which you were symptomless and stay there for 2-3 weeks before deceasing to a slow taper. NOTE: after successfully tapering from 150mg Venlafaxine down to 75mg for a month, I was unable to tolerate a drop cold turkey from a daily dosage of 75mg down to 37.50mg (50%) without having bothersome withdrawal symptoms of dizziness, brain fog, brain zaps, and nausea. So after researching various tapering plans, I came up with a slower tapering schedule my body could tolerate to finish the tapering from 75mg to 37.50mg, and then on to complete the tapering. Your body may even need slower tapering, so adjust according.
3. Week 1-2: Take 75mg caps MWFSu; take 37.50mg tab on alternate days Tu,Th, Sa. At the end of week 2, if you only have relatively mild to no withdrawal symptoms, proceed to week 3. IMPORTANT: If you have intolerable symptoms, adjust to a slower tapering schedule by adding an additional 1/2 tab on the alternate days (or take a total of one and a half 37.50 tabs on alternate days). You’ll then have to tweak the rest of your tapering schedule. If all goes well, proceed with week 3.
4. Week 3-4: Cut a few 37.50 tabs in half with a pill cutter or exacto knife blade to create quarter pieces. Take 37.50mg tab on MWFSu and take 3/4 tab on alternate days Tu, Th, Sa.
5. Week 5-6: Take 3/4 of a tab MWFSu, and take 1/2 tab on alternate days Tu, Th, Sa. If only mild symptoms, proceed to week 5.
6. Week 7-8: Take 1/2 tab on MWFSu; and take 1/4 tab on alternate days Tu, Th, Sa. If no symptoms, continue to week 7.
7. Week 9-10: Take 1/4 tab on MWFSu; and take 1/8 tab (cut 1/4 tabs in half) on alternate days Tu, Th, Sa. *Notice the quartering of doses into crumbs now...very important to keep small dosage tapering to remain withdrawal symptom free.
8. Week 11-12: Take 1/8 tab crumb on MWFSu; take none on alternate days Tu, Th, Sa. *If skipping alternate days produces symptoms, stay on 1/8 tab crumbs for a couple of weeks before alternating skip days for a couple of weeks.
You’ll find that this schedule may have to be tweaked for you by extending the time you stay on a taper...possibly up to 3-4 weeks before beginning a new tapering down. It all depends on how you tolerate the first two weeks.

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

@reginald56

Hi Anita,
Unfortunately Mayo does not let me attach Excel files. If you send me your email address I can send it to you.

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Sending again in case you didn’t receive it. anitacm@msn.com
I hope you’re ok?

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@reginald56

Having the Capsules with beads actually makes tapering very easy with the assistance of a weigh scale. After a lot of research online I decided to do a slow taper. Keeping my fingers crossed, but so far so good.
The main thing for this to work is to know:
- The weight of the bottom half of the capsule.
- The weight of the beads used in the capsule.
- I make 21 capsules at a time, and it takes about 20 min.
If anyone wishes to use my spreadsheet feel free to send me a message and I can send it to you.
I am not against meds at all, and if they are working for you, it's great. My meds numbed things when I needed them to in order to function. 6 years later I have made changes in my life, and am ready to feel myself again. Honestly I cannot remember what that felt like, it has been a hell of a road.
My taper started 3 months ago, so far I am feeling more energetic, but still not the best, but no side effects.
We will see what happens.

Depression:
- Venalafaxine 150MG now at 63.75mg
- Buproprian 150MG - Planning to stay on now.

Anxiety:
- Clonazapam 2.5mg, now at .25mg 2x daily
- Clonodine .1mg - Discontinued.

ADHD
Vivanze 40mg - Planning to stay on.

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Just checked my junk and found it. Thank you so much - you are a godsend

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@artsy6013

@artsy6013
I have read through this thread and can’t understand why people are tapering off their meds. If you said that you have been feeling really good for a long time and wanted to try to taper off meds gradually, I would understand.
I am on a high dose of Effexor xl and Wellbutrin xl which I take once a day every day.
I though about decreasing meds and asked my psychiatrist for his opinion. He said if I was doing well, why change anything? I trust him and I have the type of major depression that, untreated, has left me hospitalized on three occasions. I would be scared to death to experience that situation again and so I stay on my meds.
Is there something wrong with my thinking on this?

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Some people are very desperate to get help and this drug doesn’t work for them but often times they are advised to stay the course. When they experience bad withdrawals even with a slow taper they are even told it’s the symptoms of their depression coming back. This drug was overprescribed. I think that some people do want to get off meds for lots of reasons. I have a med I can’t stop taking without really bad withdrawals but it made me gain 60 lbs and can cause diabetes. I would rather have diabetes than a manic episode I guess but I would probably try to go off it so I could take something else if I got diabetes

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Thank you so much for sharing this Sheffield. I’m sure that it will be incredibly helpful for some people. I’ve decided to go down the weighing of the beads road as so kindly shared by Reginald and will provide an update on progress as I go along. It is so good to see this forum and understand that we are all struggling coming off this nasty drug.

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I’m wondering if you could help me tonight. Monday, my doctor advised me to stop venlafaxine (dosage 150 mg a day) cold turkey. After 4 days, I am having brain zaps, terribly vivid dreams almost to the point of feeling I am hallucinating, not dreaming, and alternating exhaustion and feelings of nervousness. What do you think? It’s the weekend and I can’t contact her. I’m afraid to go to sleep and worried I won’t be able to function tomorrow, or end up in the ER. Should I try an Urgent Care?
Thanks…😟

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@tfolger

I’m wondering if you could help me tonight. Monday, my doctor advised me to stop venlafaxine (dosage 150 mg a day) cold turkey. After 4 days, I am having brain zaps, terribly vivid dreams almost to the point of feeling I am hallucinating, not dreaming, and alternating exhaustion and feelings of nervousness. What do you think? It’s the weekend and I can’t contact her. I’m afraid to go to sleep and worried I won’t be able to function tomorrow, or end up in the ER. Should I try an Urgent Care?
Thanks…😟

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Good evening, @tfolger, and welcome to Connect. I'm sorry that your response to reducing your prescribed medicine has had side effects for which you may need help. I am sending this request to our moderator group. Hopefully, one of them will be able to respond quickly, even though it is Saturday night.

May you be free from suffering and the causes of suffering.
Chris

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@tfolger
You should not stop Effexor cold turkey.
One lady here had a stroke after doing that.
I would taper VERY gradually to increase your success rate of not having any withdrawal symptoms.
Whatever condition your taking it for (e.g. depression) is also more likely to return.
By the way, your doctor is an idiot.
Jake

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@tfolger

I’m wondering if you could help me tonight. Monday, my doctor advised me to stop venlafaxine (dosage 150 mg a day) cold turkey. After 4 days, I am having brain zaps, terribly vivid dreams almost to the point of feeling I am hallucinating, not dreaming, and alternating exhaustion and feelings of nervousness. What do you think? It’s the weekend and I can’t contact her. I’m afraid to go to sleep and worried I won’t be able to function tomorrow, or end up in the ER. Should I try an Urgent Care?
Thanks…😟

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@tfolger, it is generally advised to taper slowly off a medication like venlafaxine. If you continue to have serious side effects over the weekend, please consult professional medical help at an urgent care facility.

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@tfolger

I’m wondering if you could help me tonight. Monday, my doctor advised me to stop venlafaxine (dosage 150 mg a day) cold turkey. After 4 days, I am having brain zaps, terribly vivid dreams almost to the point of feeling I am hallucinating, not dreaming, and alternating exhaustion and feelings of nervousness. What do you think? It’s the weekend and I can’t contact her. I’m afraid to go to sleep and worried I won’t be able to function tomorrow, or end up in the ER. Should I try an Urgent Care?
Thanks…😟

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This concerns only "brain zaps." I had at least one every day. My neuolorigist suggested Gabapentin, which she thought was a last-ditch attempt, but it was very effective. I took only about 5, one per day. Now, several years later, the zaps occur much less often. When I feel one, I take one Gabapentin as needed. I hope this helps. - Steve

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@colleenyoung

@tfolger, it is generally advised to taper slowly off a medication like venlafaxine. If you continue to have serious side effects over the weekend, please consult professional medical help at an urgent care facility.

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What are brain zaps?

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