1. < Breast Cancer

Something new in the treatment arsenal?

Posted by nlb122 @nlb122, Sep 23, 2023

AstraZeneca reported positive results from a Phase 3 trial for a breast- cancer treatment, sending its American depositary receipts higher.

Shares of AstraZeneca (ticker: AZN) were up 1.7% to $68.16 in morning trading.

The company said the trial showed that the treatment, datopotamab deruxtecan, showed a significant improvement relative to chemotherapy in terms of progression-free survival. Plans to submit the drug for regulatory approval globally are underway.

Progression-free survival “is defined as the time from random assignment in a clinical trial to disease progression or death from any cause,” according to the National Library of Medicine.

Interested in more discussions like this? Go to the Breast Cancer Support Group.

anjalima | @anjalima | Apr 18 7:32am
In reply to @leeann66 "Good morning, just a little update on my recent scan. As a reminder I was diagnosed..." + (show)
@leeann66

Good morning, just a little update on my recent scan.

As a reminder I was diagnosed June 2020 de novo stage 4 breast cancer, HR+, HER2- (now considered HER2 low) Mets to bones in 7 places.

Kisqali and Anastrozole for 16 months, was NED then progression.

Also monthly XGeva injections which I still do.

Switched to Afinitor and Exemestane for about 6-8 weeks, had to stop due to bad rash and breathing trouble, continued disease progression.

Went on Xeloda for 6 months, didn’t work, continued disease progression.

Started the Tropion 01 clinical trial, phase 3, November 1, 2022.

Recent scan shows no sign of bones Mets, no sign of initial breast tumour, 3 lymph nodes still showing but have shrunk from initial scan and have remained the same size for last 6 months. Dr said it might actually be scar tissue and not cancer.

No new lesions or any evidence of disease elsewhere, all major organs continue to be clear!

Grateful for the Trial, Dato-Dxd and my medical team at the MUHC here in Montreal!!

Jump to this post

Soooo Happy for You! Great news for you and for all of us who may also need this treatment! Thank you for your generosity in sharing🌸

REPLY
tdesantis | @tdesantis | Apr 18 9:23am
In reply to @leeann66 "Good morning, just a little update on my recent scan. As a reminder I was diagnosed..." + (show)
@leeann66

Good morning, just a little update on my recent scan.

As a reminder I was diagnosed June 2020 de novo stage 4 breast cancer, HR+, HER2- (now considered HER2 low) Mets to bones in 7 places.

Kisqali and Anastrozole for 16 months, was NED then progression.

Also monthly XGeva injections which I still do.

Switched to Afinitor and Exemestane for about 6-8 weeks, had to stop due to bad rash and breathing trouble, continued disease progression.

Went on Xeloda for 6 months, didn’t work, continued disease progression.

Started the Tropion 01 clinical trial, phase 3, November 1, 2022.

Recent scan shows no sign of bones Mets, no sign of initial breast tumour, 3 lymph nodes still showing but have shrunk from initial scan and have remained the same size for last 6 months. Dr said it might actually be scar tissue and not cancer.

No new lesions or any evidence of disease elsewhere, all major organs continue to be clear!

Grateful for the Trial, Dato-Dxd and my medical team at the MUHC here in Montreal!!

Jump to this post

Hi. I am happy to hear this. I currently have a fractured rib due to one lesion they have found in that spot. I was diagnosed in August with Mets to liver and lung. And now that one rib.
I have pain in that rib. I am hoping it’s from the fracture and not the lesion. To hear you had 7 areas it must be so painful !! I am worried about the bones.

REPLY
1 reply
kensiejames | @kensiejames | Apr 19 6:58am
In reply to @leeann66 "Good morning, just a little update on my recent scan. As a reminder I was diagnosed..." + (show)
@leeann66

Good morning, just a little update on my recent scan.

As a reminder I was diagnosed June 2020 de novo stage 4 breast cancer, HR+, HER2- (now considered HER2 low) Mets to bones in 7 places.

Kisqali and Anastrozole for 16 months, was NED then progression.

Also monthly XGeva injections which I still do.

Switched to Afinitor and Exemestane for about 6-8 weeks, had to stop due to bad rash and breathing trouble, continued disease progression.

Went on Xeloda for 6 months, didn’t work, continued disease progression.

Started the Tropion 01 clinical trial, phase 3, November 1, 2022.

Recent scan shows no sign of bones Mets, no sign of initial breast tumour, 3 lymph nodes still showing but have shrunk from initial scan and have remained the same size for last 6 months. Dr said it might actually be scar tissue and not cancer.

No new lesions or any evidence of disease elsewhere, all major organs continue to be clear!

Grateful for the Trial, Dato-Dxd and my medical team at the MUHC here in Montreal!!

Jump to this post

🙏🏻🙏🏻🙏🏻

REPLY
timely | @timely | Apr 19 11:09am
In reply to @einnoc "https://www.icr.ac.uk/news-archive/research-uncovers-how-to-target-sleeping-breast-cancer-cells-and-prevent-relapse" + (show)

@einnoc
*****Everyone needs to read your above post which details a study in the UK which finds out how to block dormant cancer cells.

Plus, in the future, hopefully this will do away with taking any AI’s which would be a blessing for all.

REPLY
1 reply
vkroger | @vkroger | Apr 20 1:38pm
In reply to @timely "@einnoc *****Everyone needs to read your above post which details a study in the UK which..." + (show)
@timely

@einnoc
*****Everyone needs to read your above post which details a study in the UK which finds out how to block dormant cancer cells.

Plus, in the future, hopefully this will do away with taking any AI’s which would be a blessing for all.

Jump to this post

Omg I’d love to sign up for this study!

REPLY
leeann66 | @leeann66 | Apr 29 9:30am
In reply to @tdesantis "Hi. I am happy to hear this. I currently have a fractured rib due to one..." + (show)
@tdesantis

Hi. I am happy to hear this. I currently have a fractured rib due to one lesion they have found in that spot. I was diagnosed in August with Mets to liver and lung. And now that one rib.
I have pain in that rib. I am hoping it’s from the fracture and not the lesion. To hear you had 7 areas it must be so painful !! I am worried about the bones.

Jump to this post

Hello, the Mets in the bones actually were not painful, only my lymph nodes and breast were painful. Are you on some kind of a supplement for your bones? For example, I take an injection of Xgeva every month.

REPLY
1 reply
leeann66 | @leeann66 | Apr 29 9:33am
In reply to @chickenmom10 "You’re are amazingly fighter. There is hope for all of us !!! 🙌🙏" + (show)
@chickenmom10

You’re are amazingly fighter. There is hope for all of us !!! 🙌🙏

Jump to this post

Thank you everyone for your kind words of support and encouragement. I will keep you posted as we go along and if you have the opportunity to go on this medication, it is proving to do what it is supposed to do! Fingers crossed it continues and research continues to find new treatments for all of us. 🤞🏻🤞🏻🙏🏻🙏🏻

REPLY
leeann66 | @leeann66 | Apr 29 9:34am
In reply to @eku "I'm so happy for you! Thank you for sharing this wonderful news with us! (Quick question:..." + (show)
@eku

I'm so happy for you! Thank you for sharing this wonderful news with us!

(Quick question: The new progressions, were they all in bones?)

Jump to this post

Hello, the progressions were all in the same place they had previously been. When I was first diagnosed, I had lesions in the bones in seven places as well as lymph nodes and breast. On my first line of treatment I was NED maybe 16 months, and then disease progressed again, but in all of the same places, no new places.

REPLY
tdesantis | @tdesantis | Apr 29 2:37pm
In reply to @leeann66 "Hello, the Mets in the bones actually were not painful, only my lymph nodes and breast..." + (show)
@leeann66

Hello, the Mets in the bones actually were not painful, only my lymph nodes and breast were painful. Are you on some kind of a supplement for your bones? For example, I take an injection of Xgeva every month.

Jump to this post

HI, Was just put on Xgeva. I am still having a lot of pain in my fractured rib/ lesion area. But thinking it is the fracture and maybe not the cancer causing the pain.. I hope!

REPLY
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