What treatments are available for ampulla dysplasias?

Posted by qq1 @qq1, Apr 12 7:20pm

What treatments are available for 82 years old female patient? She has dysplasias cells in her ampulla blocking the bile fluid flow. Her 2 stents cannot maintain the flow.

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I have no medical training and don't know if her dysplasias are cancerous or not, but some of the discussion in this thread of the pancreatic cancer forum _might_ be relevant:

https://connect.mayoclinic.org/discussion/pancreatic-lesion-89-yr-old-dad-drnot-sure-if-he-can-be-treated/
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@markymarkfl
Very helpful information. Patient will have EUS in few days. Hopefully we can get a diagnosis. So far just monitoring and waiting.

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@qq1

@markymarkfl
Very helpful information. Patient will have EUS in few days. Hopefully we can get a diagnosis. So far just monitoring and waiting.

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@qq1, any update from the ultrasound?

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@colleenyoung

@qq1, any update from the ultrasound?

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During eus last week, a growth from ampulla toward common duct was observed and a tissue sample of 1.8 cm was taken. Results are reactive changes and no dysplasia or malignancy. Pathology is sending tissue samples from past biopsies to Mayo Clinic for second read. How soon will we hear back? Should we do IR to take sample from ampulla
Where has dysplasia’s in thin layer along the lining of ampulla wall to confirm if turned to cancer? One doctor suggested to place an internal drain. Another doctor suggested a variation of Whipple. Patient has been recommended not do Whipple assuming classic version due to her age by doctor suggested internal drain. Can a mini Whipple be an option? Any information on mini Whipple to provide to me? Any other options to treat her condition to clear the obstruction to allow her to digest her food?

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@qq1

During eus last week, a growth from ampulla toward common duct was observed and a tissue sample of 1.8 cm was taken. Results are reactive changes and no dysplasia or malignancy. Pathology is sending tissue samples from past biopsies to Mayo Clinic for second read. How soon will we hear back? Should we do IR to take sample from ampulla
Where has dysplasia’s in thin layer along the lining of ampulla wall to confirm if turned to cancer? One doctor suggested to place an internal drain. Another doctor suggested a variation of Whipple. Patient has been recommended not do Whipple assuming classic version due to her age by doctor suggested internal drain. Can a mini Whipple be an option? Any information on mini Whipple to provide to me? Any other options to treat her condition to clear the obstruction to allow her to digest her food?

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Mayo clinic confirmed adenocarcinoma from sample taken in January 2024 during ERCP near ampulla. Still waiting for Mayo on sample taken in April 2024 during EUS on common bile duct. What are next steps like additional testing on cancer type and grade? What oncology specialty to coordinate treatment plan?

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Urothelia Carcinoma.

Anyone can updates on the treatments and recovery.

After recovery do CT Dna

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@qq1

Mayo clinic confirmed adenocarcinoma from sample taken in January 2024 during ERCP near ampulla. Still waiting for Mayo on sample taken in April 2024 during EUS on common bile duct. What are next steps like additional testing on cancer type and grade? What oncology specialty to coordinate treatment plan?

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Hi @qq1, here’s more information from Mayo Clinic about diagnostic testing for ampullary cancer
https://www.mayoclinic.org/diseases-conditions/ampullary-cancer/diagnosis-treatment/drc-20446378

“ Ampullary cancer treatment often starts with surgery to remove the cancer. Other treatments may include chemotherapy and radiation. These other treatments can be done before or after surgery. The best treatment for your ampullary cancer depends on several factors. These include the size of the cancer, your overall health and your preferences.”

Departments that treat this condition at Mayo Clinic include:
Gastroenterology and Hepatology
Hepatobiliary and Pancreas Surgery
Oncology (Medical)
Proton Beam Therapy Program
Radiation Oncology
Surgery

Has your diagnosis been confirmed now?

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@wongyeeboon

Urothelia Carcinoma.

Anyone can updates on the treatments and recovery.

After recovery do CT Dna

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@dwongyeeboon, you can connect with other members living with urothelial carcinoma in the Bladder Cancer support group here: https://connect.mayoclinic.org/group/bladder-cancer/

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@colleenyoung

Hi @qq1, here’s more information from Mayo Clinic about diagnostic testing for ampullary cancer
https://www.mayoclinic.org/diseases-conditions/ampullary-cancer/diagnosis-treatment/drc-20446378

“ Ampullary cancer treatment often starts with surgery to remove the cancer. Other treatments may include chemotherapy and radiation. These other treatments can be done before or after surgery. The best treatment for your ampullary cancer depends on several factors. These include the size of the cancer, your overall health and your preferences.”

Departments that treat this condition at Mayo Clinic include:
Gastroenterology and Hepatology
Hepatobiliary and Pancreas Surgery
Oncology (Medical)
Proton Beam Therapy Program
Radiation Oncology
Surgery

Has your diagnosis been confirmed now?

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We are still waiting from Mayo clinic on the specimen taken on 4/18/2024 via EUS in the common duct to confirm if cancer is still localized at the ampulla.

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