Spotting Following Cortisone Injection

I had a cortisone injection to my hip about 4 years ago. I was 9 years post menopause at the time and on hormone replacement therapy. I developed vaginal bleeding about 2 days later that lasted about 5 or 6 days. I had an endometrial biopsy which was negative for cancer. I have not had any post menopausal bleeding apart from that one time so can only conclude it was related to the cortisone injection, although my gynecologist wasn't aware of that as a side effect.

Did you modify your HRT after spotting? I'm 10 yr post-menopause, on HRT, got cortisone shot in shoulder (which helped tendonitis immensely) but started vaginal bleeding 10 days after shot. Just had annual gyno exam a few weeks prior to cortisone injection and all was normal. I had no idea until reading this thread!

I’ve been wondering the same thing. I’ve had two instances now when after getting steroid shot in my hip, begin bleeding 14 or so days later. Last for a week. Also on HRT and wondering about that. I have a yearly exam with my gyno in April and plan on asking. After direst episode I had ultrasound and uterine biopsies but everything negative. Neither my gyno nor my ortho doc know anything about this happening. Wondering I if anyone else has had their gyno change their HRT due to this PMB due to injections??

I haven't contacted my gyno yet but I discontinued estradiol after 2nd day of bleeding and plan to resume after bleeding stops (its been 5 days and seems to be easing up). The steroid shot was so helpful for my shoulder issue that I'd do it again and deal with 5-7 days of bleeding, as long as it isn't creating more serious problems like polyps or uterine cancer. The gynos and ortho docs need to be better informed about this for sure!

Totally agree. At the first instance, when I hadn’t connected the injection with the bleeding, I was completely ready to just get a complete hyst. It was hard waiting on those biopsy results. And even now, wondering what these shots can be doing (besides helping my hip!), I still may go ahead with the hyst and not have to worry about that anymore

I’ve been wondering the same thing. I’ve had two instances now when after getting steroid shot in my hip, begin bleeding 14 or so days later. Last for a week. Also on HRT and wondering about that. I have a yearly exam with my gyno in April and plan on asking. After direst episode I had ultrasound and uterine biopsies but everything negative. Neither my gyno nor my ortho doc know anything about this happening. Wondering I if anyone else has had their gyno change their HRT due to this PMB due to injections??

Hi. I am 62 and had spotting 10 post kenalog injection. Ultrasound found slight thickening of endometrial lining 6/7mm so now they want to do biopsy. I wonder if steroid can cause the slight thickening? Nervous but glad to have read others had similar experience with no other findings.